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Due to the wide existence and large morphological variances of nuclei, accurate nuclei instance segmentation is still one of the most challenging tasks in computational pathology. The annotating of nuclei instances, requiring experienced…
Deep learning enables the modelling of high-resolution histopathology whole-slide images (WSI). Weakly supervised learning of tile-level data is typically applied for tasks where labels only exist on the patient or WSI level (e.g. patient…
Semantic labelling and instance segmentation are two tasks that require particularly costly annotations. Starting from weak supervision in the form of bounding box detection annotations, we propose a new approach that does not require…
We consider a light-weight method which allows to improve the explainability of localized classification networks. The method considers (Grad)CAM maps during the training process by modification of the training loss and does not require…
Cell counting in biomedical imaging is pivotal for various clinical applications, yet the interpretability of deep learning models in this domain remains a significant challenge. We propose a novel prototype-based method for interpretable…
It is assumed that pre-training provides the feature extractor with strong class transferability and that high novel class generalization can be achieved by simply reusing the transferable feature extractor. In this work, our motivation is…
1. Research question: With the growing interest in skin diseases and skin aesthetics, the ability to predict facial wrinkles is becoming increasingly important. This study aims to evaluate whether a computational model, convolutional neural…
Segmentation of tumors in brain MRI images is a challenging task, where most recent methods demand large volumes of data with pixel-level annotations, which are generally costly to obtain. In contrast, image-level annotations, where only…
Precise segmentation of a lesion area is important for optimizing its treatment. Deep learning makes it possible to detect and segment a lesion field using annotated data. However, obtaining precisely annotated data is very challenging in…
Deep neural networks usually require accurate and a large number of annotations to achieve outstanding performance in medical image segmentation. One-shot segmentation and weakly-supervised learning are promising research directions that…
Brain tumor classification using MRI images is critical in medical diagnostics, where early and accurate detection significantly impacts patient outcomes. While recent advancements in deep learning (DL), particularly CNNs, have shown…
While deep learning methods are increasingly being applied to tasks such as computer-aided diagnosis, these models are difficult to interpret, do not incorporate prior domain knowledge, and are often considered as a "black-box." The lack of…
Weakly supervised segmentation is an important problem in medical image analysis due to the high cost of pixelwise annotation. Prior methods, while often focusing on weak labels of 2D images, exploit few structural cues of volumetric…
Despite deep convolutional neural networks achieved impressive progress in medical image computing and analysis, its paradigm of supervised learning demands a large number of annotations for training to avoid overfitting and achieving…
Despite their superior performance, deep-learning methods often suffer from the disadvantage of needing large-scale well-annotated training data. In response, recent literature has seen a proliferation of efforts aimed at reducing the…
Developing an AI-assisted gland segmentation method from histology images is critical for automatic cancer diagnosis and prognosis; however, the high cost of pixel-level annotations hinders its applications to broader diseases. Existing…
We propose a novel weakly-supervised semantic segmentation algorithm based on Deep Convolutional Neural Network (DCNN). Contrary to existing weakly-supervised approaches, our algorithm exploits auxiliary segmentation annotations available…
Multi-class cell segmentation in high-resolution Giga-pixel whole slide images (WSI) is critical for various clinical applications. Training such an AI model typically requires labor-intensive pixel-wise manual annotation from experienced…
We propose a general framework called Network Dissection for quantifying the interpretability of latent representations of CNNs by evaluating the alignment between individual hidden units and a set of semantic concepts. Given any CNN model,…
Exponential growth in Electronic Healthcare Records (EHR) has resulted in new opportunities and urgent needs for discovery of meaningful data-driven representations and patterns of diseases in Computational Phenotyping research. Deep…