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Medical image annotation is a major hurdle for developing precise and robust machine learning models. Annotation is expensive, time-consuming, and often requires expert knowledge, particularly in the medical field. Here, we suggest using…

Computer Vision and Pattern Recognition · Computer Science 2020-09-28 Holger R Roth , Dong Yang , Ziyue Xu , Xiaosong Wang , Daguang Xu

Accurate segmentation of organelle instances from electron microscopy (EM) images plays an essential role in many neuroscience researches. However, practical scenarios usually suffer from high annotation costs, label scarcity, and large…

Computer Vision and Pattern Recognition · Computer Science 2024-04-02 Dafei Qiu , Shan Xiong , Jiajin Yi , Jialin Peng

We propose a novel perspective to understand deep neural networks in an interpretable disentanglement form. For each semantic class, we extract a class-specific functional subnetwork from the original full model, with compressed structure…

Machine Learning · Computer Science 2019-10-08 Yulong Wang , Xiaolin Hu , Hang Su

AI-assisted nuclei segmentation in histopathological images is a crucial task in the diagnosis and treatment of cancer diseases. It decreases the time required to manually screen microscopic tissue images and can resolve the conflict…

Image and Video Processing · Electrical Eng. & Systems 2023-11-21 Hesham Ali , Idriss Tondji , Mennatullah Siam

Automated semantic segmentation of cell nuclei in microscopic images is crucial for disease diagnosis and tissue microenvironment analysis. Nonetheless, this task presents challenges due to the complexity and heterogeneity of cells. While…

Image and Video Processing · Electrical Eng. & Systems 2023-08-10 Zhuchen Shao , Sourya Sengupta , Hua Li , Mark A. Anastasio

We present a novel neural network architecture, US-Net, for robust nuclei instance segmentation in histopathology images. The proposed framework integrates the nuclei detection and segmentation networks by sharing their outputs through the…

Computer Vision and Pattern Recognition · Computer Science 2019-02-04 Zhaoyang Xu , Faranak Sobhani , Carlos Fernandez Moro , Qianni Zhang

Nuclei detection is an important task in the histology domain as it is a main step toward further analysis such as cell counting, cell segmentation, study of cell connections, etc. This is a challenging task due to the complex texture of…

Computer Vision and Pattern Recognition · Computer Science 2018-08-28 Navid Alemi Koohababni , Mostafa Jahanifar , Ali Gooya , Nasir Rajpoot

Nuclei appear small in size, yet, in real clinical practice, the global spatial information and correlation of the color or brightness contrast between nuclei and background, have been considered a crucial component for accurate nuclei…

Image and Video Processing · Electrical Eng. & Systems 2023-07-18 Zhenqi He , Mathias Unberath , Jing Ke , Yiqing Shen

Object segmentation is an important step in the workflow of computational pathology. Deep learning based models generally require large amount of labeled data for precise and reliable prediction. However, collecting labeled data is…

Computer Vision and Pattern Recognition · Computer Science 2020-07-08 Navid Alemi Koohbanani , Mostafa Jahanifar , Neda Zamani Tajadin , Nasir Rajpoot

Automated detection and segmentation of pulmonary nodules on lung computed tomography (CT) scans can facilitate early lung cancer diagnosis. Existing supervised approaches for automated nodule segmentation on CT scans require voxel-based…

Computer Vision and Pattern Recognition · Computer Science 2018-02-26 Xinyang Feng , Jie Yang , Andrew F. Laine , Elsa D. Angelini

Mode decomposition is a prototypical pattern recognition problem that can be addressed from the (a priori distinct) perspectives of numerical approximation, statistical inference and deep learning. Could its analysis through these combined…

Machine Learning · Statistics 2020-08-07 Houman Owhadi , Clint Scovel , Gene Ryan Yoo

Accurate cell segmentation in pathology images typically requires dense pixel-wise annotations, which are costly and time-consuming to obtain. This challenge is especially important for emerging biological imaging modalities and multiplexed…

Computer Vision and Pattern Recognition · Computer Science 2026-05-26 Gunjan Shrivastava , Saad Nadeem

Accurate segmentation of organelle instances, e.g., mitochondria, is essential for electron microscopy analysis. Despite the outstanding performance of fully supervised methods, they highly rely on sufficient per-pixel annotated data and…

Computer Vision and Pattern Recognition · Computer Science 2022-11-01 Dafei Qiu , Jiajin Yi , Jialin Peng

Accurate nuclei detection and classification are fundamental to computational pathology, yet existing approaches are hindered by reliance on detailed expert annotations and insufficient use of tissue context. We present Tissue-Aware Nuclei…

Computer Vision and Pattern Recognition · Computer Science 2025-11-18 Kesi Xu , Eleni Chiou , Ali Varamesh , Laura Acqualagna , Nasir Rajpoot

Dense annotations, such as segmentation masks, are expensive and time-consuming to obtain, especially for 3D medical images where expert voxel-wise labeling is required. Weakly supervised approaches aim to address this limitation, but often…

Computer Vision and Pattern Recognition · Computer Science 2026-04-21 Richard Petersen , Fredrik Kahl , Jennifer Alvén

Unsupervised domain adaptation (UDA) methods have been broadly utilized to improve the models' adaptation ability in general computer vision. However, different from the natural images, there exist huge semantic gaps for the nuclei from…

Computer Vision and Pattern Recognition · Computer Science 2022-07-05 Canran Li , Dongnan Liu , Haoran Li , Zheng Zhang , Guangming Lu , Xiaojun Chang , Weidong Cai

Weakly supervised segmentation methods have gained significant attention due to their ability to reduce the reliance on costly pixel-level annotations during model training. However, the current weakly supervised nuclei segmentation…

Image and Video Processing · Electrical Eng. & Systems 2025-02-04 Ye Zhang , Yifeng Wang , Zijie Fang , Hao Bian , Linghan Cai , Ziyue Wang , Yongbing Zhang

Segmentation and classification of large numbers of instances, such as cell nuclei, are crucial tasks in digital pathology for accurate diagnosis. However, the availability of high-quality datasets for deep learning methods is often limited…

Computer Vision and Pattern Recognition · Computer Science 2024-10-21 Laura Gálvez Jiménez , Christine Decaestecker

Human skin segmentation is a crucial task in computer vision and biometric systems, yet it poses several challenges such as variability in skin color, pose, and illumination. This paper presents a robust data-driven skin segmentation method…

Computer Vision and Pattern Recognition · Computer Science 2023-02-10 Kooshan Hashemifard , Pau Climent-Perez , Francisco Florez-Revuelta

The reasonable definition of semantic interpretability presents the core challenge in explainable AI. This paper proposes a method to modify a traditional convolutional neural network (CNN) into an interpretable compositional CNN, in order…

Computer Vision and Pattern Recognition · Computer Science 2021-07-12 Wen Shen , Zhihua Wei , Shikun Huang , Binbin Zhang , Jiaqi Fan , Ping Zhao , Quanshi Zhang