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As a multitude of capable machine learning (ML) models become widely available in forms such as open-source software and public APIs, central questions remain regarding their use in real-world applications, especially in high-stakes…

Machine Learning · Computer Science 2024-06-03 Dimitris Bertsimas , Matthew Peroni

Clinical trials are critical for drug development but often suffer from expensive and inefficient patient recruitment. In recent years, machine learning models have been proposed for speeding up patient recruitment via automatically…

Machine Learning · Computer Science 2023-07-20 Brandon Theodorou , Cao Xiao , Jimeng Sun

Clustering serves as a vital tool for uncovering latent data structures, and achieving both high accuracy and interpretability is essential. To this end, existing methods typically construct binary decision trees by solving mixed-integer…

Machine Learning · Computer Science 2026-02-17 Hayato Suzuki , Shunnosuke Ikeda , Yuichi Takano

Poor interpretability hinders the practical applicability of multi-agent reinforcement learning (MARL) policies. Deploying interpretable surrogates of uninterpretable policies enhances the safety and verifiability of MARL for real-world…

Multiagent Systems · Computer Science 2025-08-13 Rex Chen , Stephanie Milani , Zhicheng Zhang , Norman Sadeh , Fei Fang

Interpretability of reinforcement learning policies is essential for many real-world tasks but learning such interpretable policies is a hard problem. Particularly rule-based policies such as decision trees and rules lists are difficult to…

Artificial Intelligence · Computer Science 2024-02-15 Daniël Vos , Sicco Verwer

Sparse decision trees are one of the most common forms of interpretable models. While recent advances have produced algorithms that fully optimize sparse decision trees for prediction, that work does not address policy design, because the…

Machine Learning · Computer Science 2022-10-27 Ali Behrouz , Mathias Lecuyer , Cynthia Rudin , Margo Seltzer

Offline reinforcement learning (RL) holds great promise for deriving optimal policies from observational data, but challenges related to interpretability and evaluation limit its practical use in safety-critical domains. Interpretability is…

Machine Learning · Computer Science 2025-07-24 Anton Matsson , Yaochen Rao , Heather J. Litman , Fredrik D. Johansson

Multiple lines of evidence suggest that predictive models may benefit from algorithmic triage. Under algorithmic triage, a predictive model does not predict all instances but instead defers some of them to human experts. However, the…

Machine Learning · Statistics 2021-11-19 Nastaran Okati , Abir De , Manuel Gomez-Rodriguez

Decision makers, such as doctors and judges, make crucial decisions such as recommending treatments to patients, and granting bails to defendants on a daily basis. Such decisions typically involve weighting the potential benefits of taking…

Artificial Intelligence · Computer Science 2016-10-25 Himabindu Lakkaraju , Cynthia Rudin

In this work, we present a flexible method for explaining, in human readable terms, the predictions made by decision trees used as decision support in liver transplantation. The decision trees have been obtained through machine learning…

Artificial Intelligence · Computer Science 2021-09-29 Pedro Cabalar , Brais Muñiz , Gilberto Pérez , Francisco Suárez

The COVID-19 pandemic has created unprecedented challenges worldwide. Strained healthcare providers make difficult decisions on patient triage, treatment and care management on a daily basis. Policy makers have imposed social distancing…

Trustworthy Artificial Intelligence solutions are essential in today's data-driven applications, prioritizing principles such as robustness, safety, transparency, explainability, and privacy among others. This has led to the emergence of…

Machine Learning · Computer Science 2024-04-04 Alberto Argente-Garrido , Cristina Zuheros , M. Victoria Luzón , Francisco Herrera

The allocation of scarce donor organs constitutes one of the most consequential algorithmic challenges in healthcare. While the field is rapidly transitioning from rigid, rule-based systems to machine learning and data-driven optimization,…

Machine Learning · Computer Science 2026-05-27 Ioannis Anagnostides , Itai Zilberstein , Zachary W. Sollie , Arman Kilic , Tuomas Sandholm

Interpretable policy learning seeks to estimate intelligible decision policies from observed actions; however, existing models force a tradeoff between accuracy and interpretability, limiting data-driven interpretations of human…

Machine Learning · Computer Science 2024-05-09 Jannik Deuschel , Caleb N. Ellington , Yingtao Luo , Benjamin J. Lengerich , Pascal Friederich , Eric P. Xing

The management of invasive mechanical ventilation, and the regulation of sedation and analgesia during ventilation, constitutes a major part of the care of patients admitted to intensive care units. Both prolonged dependence on mechanical…

Artificial Intelligence · Computer Science 2017-04-24 Niranjani Prasad , Li-Fang Cheng , Corey Chivers , Michael Draugelis , Barbara E Engelhardt

Decision tree optimization is fundamental to interpretable machine learning. The most popular approach is to greedily search for the best feature at every decision point, which is fast but provably suboptimal. Recent approaches find the…

Machine Learning · Computer Science 2025-11-19 Varun Babbar , Hayden McTavish , Cynthia Rudin , Margo Seltzer

We study the problem of allocating scarce societal resources of different types (e.g., permanent housing, deceased donor kidneys for transplantation, ventilators) to heterogeneous allocatees on a waitlist (e.g., people experiencing…

Optimization and Control · Mathematics 2025-08-13 Bill Tang , Çağıl Koçyiğit , Eric Rice , Phebe Vayanos

Recent years have seen increasing efforts to forecast infectious disease burdens, with a primary goal being to help public health workers make informed policy decisions. However, there has only been limited discussion of how predominant…

Applications · Statistics 2024-03-06 Aaron Gerding , Nicholas G. Reich , Benjamin Rogers , Evan L. Ray

Fairness and interpretability play an important role in the adoption of decision-making algorithms across many application domains. These requirements are intended to avoid undesirable group differences and to alleviate concerns related to…

Econometrics · Economics 2025-09-16 Nora Bearth , Michael Lechner , Jana Mareckova , Fabian Muny

We analyze a tree search problem with an underlying Markov decision process, in which the goal is to identify the best action at the root that achieves the highest cumulative reward. We present a new tree policy that optimally allocates a…

Systems and Control · Electrical Eng. & Systems 2020-09-29 Yunchuan Li , Michael C. Fu , Jie Xu