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Surface-enhanced Raman spectroscopy (SERS) allows single-molecule detection due to the strong field localization occurring at sharp bends or kinks of the metal-vacuum interface. An important question concerns the limits of the signal…

Optics · Physics 2008-06-19 Sanshui Xiao , Niels Asger Mortensen , Antti-Pekka Jauho

Ultrafast, high quantum efficiency single photon detectors are among the most sought-after elements in modern quantum optics and quantum communication. High photon detection efficiency is essential for scalable measurement-based quantum…

Optics · Physics 2015-05-30 W. Pernice , C. Schuck , O. Minaeva , M. Li , G. N. Goltsman , A. V. Sergienko , H. X. Tang

We developed a nanoplasmonic sensor platform employing the extraordinary optical properties of one-dimensional nanogratings patterned on 30nm-thick ultrathin Ag films. Excitation of Fano resonances in the ultrathin Ag nanogratings results…

Optics · Physics 2014-10-15 Beibei Zeng , Yongkang Gao , Filbert J. Bartoli

DNA microarrays are a relatively new technology that can simultaneously measure the expression level of thousands of genes. They have become an important tool for a wide variety of biological experiments. One of the most common goals of DNA…

Methodology · Statistics 2013-07-02 Eric Bair

Artefacts compromise clinical decision-making in the use of medical time series. Pulsatile waveforms offer probabilities for accurate artefact detection, yet most approaches rely on supervised manners and overlook patient-level distribution…

Signal Processing · Electrical Eng. & Systems 2025-05-01 Xuhang Chen , Ihsane Olakorede , Stefan Yu Bögli , Wenhao Xu , Erta Beqiri , Xuemeng Li , Chenyu Tang , Zeyu Gao , Shuo Gao , Ari Ercole , Peter Smielewski

Genome sequence analysis plays a pivotal role in enabling many medical and scientific advancements in personalized medicine, outbreak tracing, and forensics. However, the analysis of genome sequencing data is currently bottlenecked by the…

Hardware Architecture · Computer Science 2021-11-04 Damla Senol Cali

Freestanding Silicon nitride (SiN) devices are central to the field of nanomechanical resonators and for other technology applications such as transmission electron imaging and nanopore bioassays. The nanofabrication techniques used for…

Optics · Physics 2023-03-22 Roghayeh Nikbakht , Xitong Xie , Arnaud Weck , Raphael St-Gelais

Nanopore sequencing is a widely-used high-throughput genome sequencing technology that can sequence long fragments of a genome into raw electrical signals at low cost. Nanopore sequencing requires two computationally-costly processing steps…

This study introduces a graphene-assisted terahertz metamaterial absorber operating at a resonance frequency of 8.436 THz. The unit cell incorporates a graphene-based split-ring resonator (SRR) configuration with additional auxiliary splits…

The decreasing costs and increasing speed and accuracy of DNA sample collection, preparation, and sequencing has rapidly produced an enormous volume of genetic data. However, fast and accurate analysis of the samples remains a bottleneck.…

Quantitative Methods · Quantitative Biology 2017-04-13 Stephanie Dodson , Darrell O. Ricke , Jeremy Kepner , Nelson Chiu , Anna Shcherbina

With ever increasing research on magnetic nano systems it is shown to have great potential in the areas of magnetic storage, biosensing, magnetoresistive insulation etc. In the field of biosensing specifically Spin Valve sensors coupled…

Emerging Technologies · Computer Science 2015-12-01 Tathagata Srimani , Bibhas Manna , Anand Kumar Mukhopadhyay , Kaushik Roy , Mrigank Sharad

Oxygen (O2)-sensing matrices are promising tools for the live monitoring of extracellular O2 consumption levels in long-term cell cultures. In this study, ratiometric O2-sensing membranes were prepared by electrospinning, an easy, low-cost,…

Recent analysis identified distinct genomic subtypes of lower-grade glioma tumors which are associated with shape features. In this study, we propose a fully automatic way to quantify tumor imaging characteristics using deep learning-based…

Image and Video Processing · Electrical Eng. & Systems 2019-06-11 Mateusz Buda , Ashirbani Saha , Maciej A Mazurowski

We offer new high-performance label-free electrochemical impedimetric DNA sensors of non-faradaic type. The DNA sensors based on a platform of crystalline carbon nanotube (CNT) arrays are fabricated by the Langmuir--Blodgett (LB) deposition…

The ability to quickly and accurately identify microbial species in a sample, known as metagenomic profiling, is critical across various fields, from healthcare to environmental science. This paper introduces a novel method to profile…

Genomics · Quantitative Biology 2025-04-10 Riselda Kodra , Hadjer Benmeziane , Irem Boybat , William Andrew Simon

We present a new methodology for efficient and high-quality patterning of biological reagents for surface-based biological assays. The method relies on hydrodynamically confined nanoliter volumes of reagents to interact with the substrate…

Biomolecules · Quantitative Biology 2016-04-27 J. Autebert , J. F. Cors , David P. Taylor , G. V. Kaigala

DNA microarrays are devices that are able, in principle, to detect and quantify the presence of specific nucleic acid sequences in complex biological mixtures. The measurement consists in detecting fluorescence signals from several spots on…

Biomolecules · Quantitative Biology 2008-06-30 K. M. Kroll , G. T. Barkema , E. Carlon

Next-generation sequencing (NGS) technologies have enabled affordable sequencing of billions of short DNA fragments at high throughput, paving the way for population-scale genomics. Genomics data analytics at this scale requires overcoming…

Databases · Computer Science 2019-10-11 Darryl Ho , Jialin Ding , Sanchit Misra , Nesime Tatbul , Vikram Nathan , Vasimuddin Md , Tim Kraska

Surface enhanced Raman spectroscopy (SERS) was used to probe the surface chemistry of chlorine-terminated silicon nanocrystal (Si-NC) surfaces in an air-free environment. SERS effect was observed from the thin films of Ag$_x$O using 514 nm…

Materials Science · Physics 2016-06-28 İlker Doğan , Ryan Gresback , Tomohiro Nozaki , Mauritius C. M. van de Sanden

The advent of DNA and RNA sequencing has revolutionized the study of genomics and molecular biology. Next generation sequencing (NGS) technologies like Illumina, Ion Torrent, SOLiD sequencing etc. have brought about a quick and cheap way to…

Genomics · Quantitative Biology 2021-03-26 Yun Heo , Gowthami Manikandan , Anand Ramachandran , Deming Chen
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