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The paper addresses the study of a class of evolutionary quasi-variational inequalities of the parabolic type arising in the formation and growth models of granular and cohensionless materials. Such models and their mathematical…

Optimization and Control · Mathematics 2022-09-02 Harbir Antil , Rafael Arndt , Boris S. Mordukhovich , Dao Nguyen , Carlos N. Rautenberg

Most three dimensional constitutive relations that have been developed to describe the behavior of bodies are correlated against one dimensional and two dimensional experiments. What is usually lost sight of is the fact that infinity of…

Numerical Analysis · Computer Science 2010-07-23 Satish Karra , K. R. Rajagopal

Based on a recently proposed non-equilibrium mechanism for spatial pattern formation [cond-mat/0312366] we study how morphogenesis can be controlled by locally coupled discrete dynamical networks, similar to gene regulation networks of…

Molecular Networks · Quantitative Biology 2007-05-23 Thimo Rohlf , Stefan Bornholdt

In this paper, we address an optimal distributed control problem for a non-local model of phase-field type, describing the evolution of tumour cells in presence of a nutrient. The model couples a non-local and viscous Cahn-Hilliard equation…

Analysis of PDEs · Mathematics 2023-10-25 Matteo Fornoni

The mechanism by which cells measure the dimension of the organ in which they are embedded, and slow down their growth when the final size is reached, is a long-standing problem of developmental biology. The role of mechanics in this…

Biological Physics · Physics 2023-07-19 Alexander Erlich , Pierre Recho

We identify effective models for thin, linearly elastic and perfectly plastic plates exhibiting a microstructure resulting from the periodic alternation of two elastoplastic phases. We study here both the case in which the thickness of the…

Analysis of PDEs · Mathematics 2023-03-01 Marin Bužančić , Elisa Davoli , Igor Velčić

Alternative approach for description of the non-equilibrium phenomena arising in solids at a severe external loading is analyzed. The approach is based on the new form of kinetic equations in terms of the internal and modified free energy.…

Statistical Mechanics · Physics 2014-08-27 L. S. Metlov

We consider a particular phase field system which physical context is that of tumor growth dynamics. The model we deal with consists of a Cahn-Hilliard type equation governing the evolution of the phase variable which takes into account the…

Analysis of PDEs · Mathematics 2019-08-30 Andrea Signori

This paper investigates the stability of the power-law steady state often observed in marine ecosystems. Three dynamical systems are considered, describing the abundance of organisms as a function of body mass and time: a "jump-growth"…

Populations and Evolution · Quantitative Biology 2010-11-29 Samik Datta , Gustav W. Delius , Richard Law , Michael J. Plank

Existence and uniqueness of solutions for a class of models for stress-modulated growth is proven in one spatial dimension. The model features the multiplicative decomposition of the deformation gradient $F$ into an elastic part $F_e$ and a…

Analysis of PDEs · Mathematics 2022-11-28 Kira Bangert , Georg Dolzmann

The mathematical modeling of numerous real-world applications results in hierarchical optimization problems with two decision makers where at least one of them has to solve an optimal control problem of ordinary or partial differential…

Optimization and Control · Mathematics 2019-06-20 Patrick Mehlitz , Gerd Wachsmuth

Plants are a paradigm for active shape control in response to stimuli. For instance, it is well-known that a tilted plant will eventually straighten vertically, demonstrating the influence of both an external stimulus, gravity, and an…

Biological Physics · Physics 2025-09-09 Hadrien Oliveri , Derek E. Moulton , Heather A. Harrington , Alain Goriely

This paper investigates an optimal control problem associated with a two-dimensional multi-species Cahn-Hilliard-Keller-Segel tumor growth model, which incorporates complex biological processes such as species diffusion, chemotaxis,…

Analysis of PDEs · Mathematics 2024-07-26 Pierluigi Colli , Gianni Gilardi , Andrea Signori , Jürgen Sprekels

We establish the connection between the standard ADM 3+1 treatment of matter with its characteristic equivalent, in the context of spherical symmetry. The flux-conservative rendition of the fluid equations are obtained. Considering…

General Relativity and Quantum Cosmology · Physics 2015-06-16 W. Barreto

Tumour spheroids have been the focus of a variety of mathematical models, ranging from Greenspan's classical study of the 1970s through to contemporary agent-based models. Of the many factors that regulate spheroid growth, mechanical…

Tissues and Organs · Quantitative Biology 2022-12-22 Benjamin J. Walker , Giulia L. Celora , Alain Goriely , Derek E. Moulton , Helen M. Byrne

An effective model is identified for thin perfectly plastic plates whose microstructure consists of the periodic assembling of two elastoplastic phases, as the periodicity parameter converges to zero. Assuming that the thickness of the…

Analysis of PDEs · Mathematics 2022-12-06 Marin Bužančić , Elisa Davoli , Igor Velčić

A general theory of thermodynamically consistent biomechanical--biochemical growth in a body, considering mass addition in the bulk and at an incoherent interface, is developed. The incoherency arises due to incompatibility of growth and…

Biological Physics · Physics 2018-02-07 Digendranath Swain , Anurag Gupta

This paper presents a mathematical framework for optimizing drug delivery in cancer treatment using a nonlocal model of solid tumor growth. We present a coupled system of partial differential equations that incorporate long-range cellular…

Optimization and Control · Mathematics 2025-03-13 Bouhamidi Abderrahman , El Harraki Imad , Melouani Yassine

Based on a non-equilibrium mechanism for spatial pattern formation we study how position information can be controlled by locally coupled discrete dynamical networks, similar to gene regulation networks of cells in a developing…

Molecular Networks · Quantitative Biology 2009-08-26 Thimo Rohlf , Stefan Bornholdt

A limited mobility nonequilibrium solid-on-solid dynamical model for kinetic surface growth is introduced as a simple description for the morphological evolution of a growing interface under random vapor deposition and surface diffusion…

Statistical Mechanics · Physics 2007-05-23 S. Das Sarma , P. Punyindu