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Related papers: Interpretable Machine Learning for Genomics

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Explainable ML algorithms are designed to provide transparency and insight into their decision-making process. Explaining how ML models come to their prediction is critical in fields such as healthcare and finance, as it provides insight…

Quantum Physics · Physics 2025-06-17 Barra White , Krishnendu Guha

Machine Learning (ML) and its applications have been transforming our lives but it is also creating issues related to the development of fair, accountable, transparent, and ethical Artificial Intelligence. As the ML models are not fully…

Applications · Statistics 2021-06-30 Yihuang Kang , Yi-Wen Chiu , Ming-Yen Lin , Fang-yi Su , Sheng-Tai Huang

Recent large language models (LLMs) have demonstrated remarkable prediction performance for a growing array of tasks. However, their proliferation into high-stakes domains (e.g. medicine) and compute-limited settings has created a…

Artificial Intelligence · Computer Science 2023-12-05 Chandan Singh , Armin Askari , Rich Caruana , Jianfeng Gao

Detection of easily missed hidden patterns with fast processing power makes machine learning (ML) indispensable to today's healthcare system. Though many ML applications have already been discovered and many are still under investigation,…

Machine Learning · Computer Science 2023-07-27 Mrinmoy Roy , Sarwar J. Minar , Porarthi Dhar , A T M Omor Faruq

The key to success in machine learning (ML) is the use of effective data representations. Traditionally, data representations were hand-crafted. Recently it has been demonstrated that, given sufficient data, deep neural networks can learn…

Machine Learning · Computer Science 2018-11-09 Ivan Olier , Oghenejokpeme I. Orhobor , Joaquin Vanschoren , Ross D. King

The lack of interpretability and transparency are preventing economists from using advanced tools like neural networks in their empirical research. In this paper, we propose a class of interpretable neural network models that can achieve…

Econometrics · Economics 2020-12-01 Yucheng Yang , Zhong Zheng , Weinan E

Increasing number of sectors which affect human lives, are using Machine Learning (ML) tools. Hence the need for understanding their working mechanism and evaluating their fairness in decision-making, are becoming paramount, ushering in the…

Machine Learning · Computer Science 2020-05-11 Sreejita Ghosh , Peter Tino , Kerstin Bunte

As machine learning systems are increasingly used in high-stakes domains, there is a growing emphasis placed on making them interpretable to improve trust in these systems. In response, a range of interpretable machine learning (IML)…

Machine Learning · Statistics 2025-05-22 Luqin Gan , Tarek M. Zikry , Genevera I. Allen

Machine learning (ML) is becoming increasingly crucial in many fields of engineering but has not yet played out its full potential in bioprocess engineering. While experimentation has been accelerated by increasing levels of lab automation,…

Deep learning (DL) models have been popular due to their ability to learn directly from the raw data in an end-to-end paradigm, alleviating the concern of a separate error-prone feature extraction phase. Recent DL-based neuroimaging studies…

Machine Learning · Computer Science 2023-07-20 Md. Mahfuzur Rahman , Vince D. Calhoun , Sergey M. Plis

Definitive evidence that globular clusters (GCs) host intermediate-mass black holes (IMBHs) is elusive. Machine learning (ML) models trained on GC simulations can in principle predict IMBH host candidates based on observable features. This…

Astrophysics of Galaxies · Physics 2023-10-31 Mario Pasquato , Piero Trevisan , Abbas Askar , Pablo Lemos , Gaia Carenini , Michela Mapelli , Yashar Hezaveh

A task of interest in machine learning (ML) is that of ascribing explanations to the predictions made by ML models. Furthermore, in domains deemed high risk, the rigor of explanations is paramount. Indeed, incorrect explanations can and…

Artificial Intelligence · Computer Science 2025-07-11 Mohamed Siala , Jordi Planes , Joao Marques-Silva

RNAs play crucial and versatile roles in biological processes. Computational prediction approaches can help to understand RNA structures and their stabilizing factors, thus providing information on their functions, and facilitating the…

Biological Physics · Physics 2020-09-04 Bin Huang , Yuanyang Du , Shuai Zhang , Wenfei Li , Jun Wang , Jian Zhang

Machine learning (ML) models have significantly impacted various domains in our everyday lives. While large language models (LLMs) offer intuitive interfaces and versatility, task-specific ML models remain valuable for their efficiency and…

Human-Computer Interaction · Computer Science 2024-12-04 Wataru Kawabe , Yusuke Sugano

Scientific progress is tightly coupled to the emergence of new research tools. Today, machine learning (ML)-especially deep learning (DL)-has become a transformative instrument for quantum science and technology. Owing to the intrinsic…

Quantum Physics · Physics 2025-08-15 Timothy Heightman , Marcin Płodzień

Large language models (LLMs) are having transformative impacts across a wide range of scientific fields, particularly in the biomedical sciences. Just as the goal of Natural Language Processing is to understand sequences of words, a major…

Genomics · Quantitative Biology 2024-09-24 Gonzalo Benegas , Chengzhong Ye , Carlos Albors , Jianan Canal Li , Yun S. Song

Deep neural networks excel in mapping genomic DNA sequences to associated readouts (e.g., protein-DNA binding). Beyond prediction, the goal of these networks is to reveal to scientists the underlying motifs (and their syntax) which drive…

Genomics · Quantitative Biology 2024-10-10 Alex M. Tseng , Gokcen Eraslan , Tommaso Biancalani , Gabriele Scalia

Machine learning (ML) techniques play a pivotal role in high-stakes domains such as healthcare, where accurate predictions can greatly enhance decision-making. However, most high-performing methods such as neural networks and ensemble…

Artificial Intelligence · Computer Science 2026-01-08 Sanne Wielinga , Jesse Heyninck

The rapid advent of machine learning (ML) and artificial intelligence (AI) has catalyzed major transformations in chemistry, yet the application of these methods to spectroscopic and spectrometric data, referred to as Spectroscopy Machine…

There is a growing concern about typically opaque decision-making with high-performance machine learning algorithms. Providing an explanation of the reasoning process in domain-specific terms can be crucial for adoption in risk-sensitive…

Computer Vision and Pattern Recognition · Computer Science 2022-11-28 Aditya Chattopadhyay , Stewart Slocum , Benjamin D. Haeffele , Rene Vidal , Donald Geman