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In this paper we present web-liver, a rule-based system for decision support in the medical domain, focusing on its application in a liver transplantation unit for implementing policies for donor-patient matching. The rule-based system is…

Logic in Computer Science · Computer Science 2019-09-19 Felicidad Aguado , Pedro Cabalar , Jorge Fandinno , Brais Muñiz , Gilberto Pérez , Francisco Suárez

Background: Many authors have described MELD as a predictor of short-term mortality in the liver transplantation waiting list. However MELD score accuracy to predict long term mortality has not been statistically evaluated. Objective: The…

Recent efforts in Machine Learning (ML) interpretability have focused on creating methods for explaining black-box ML models. However, these methods rely on the assumption that simple approximations, such as linear models or decision-trees,…

Machine Learning · Computer Science 2019-06-13 Owen Lahav , Nicholas Mastronarde , Mihaela van der Schaar

Organ transplant is the essential treatment method for some end-stage diseases, such as liver failure. Analyzing the post-transplant cause of death (CoD) after organ transplant provides a powerful tool for clinical decision making,…

Machine Learning · Computer Science 2023-10-09 Sirui Ding , Qiaoyu Tan , Chia-yuan Chang , Na Zou , Kai Zhang , Nathan R. Hoot , Xiaoqian Jiang , Xia Hu

Artificial intelligence (AI)-based decision support systems have demonstrated value in predicting post-hepatectomy liver failure (PHLF) in hepatocellular carcinoma (HCC). However, they often lack transparency, and the impact of model…

Accurate and interpretable diagnostic models are crucial in the safety-critical field of medicine. We investigate the interpretability of our proposed biomarker-based lung ultrasound diagnostic pipeline to enhance clinicians' diagnostic…

Tree-based machine learning models such as random forests, decision trees, and gradient boosted trees are the most popular non-linear predictive models used in practice today, yet comparatively little attention has been paid to explaining…

Interpretability has become incredibly important as machine learning is increasingly used to inform consequential decisions. We propose to construct global explanations of complex, blackbox models in the form of a decision tree…

Machine Learning · Computer Science 2019-01-28 Osbert Bastani , Carolyn Kim , Hamsa Bastani

In this study, we present a novel clinical decision support system and discuss its interpretability-related properties. It combines a decision set of rules with a machine learning scheme to offer global and local interpretability. More…

Methodology · Statistics 2021-07-16 Francisco Valente , Simão Paredes , Jorge Henriques

Explaining neural model predictions to users requires creativity. Especially in enterprise applications, where there are costs associated with users' time, and their trust in the model predictions is critical for adoption. For link…

Prediction of survival in patients diagnosed with a brain tumour is challenging because of heterogeneous tumour behaviours and responses to treatment. Better estimations of prognosis would support treatment planning and patient support.…

Machine Learning · Computer Science 2021-06-18 Colleen E. Charlton , Michael Tin Chung Poon , Paul M. Brennan , Jacques D. Fleuriot

Despite outstanding contribution to the significant progress of Artificial Intelligence (AI), deep learning models remain mostly black boxes, which are extremely weak in explainability of the reasoning process and prediction results.…

Machine Learning · Computer Science 2020-02-11 Sheng Shi , Xinfeng Zhang , Wei Fan

Liver transplant is an essential therapy performed for severe liver diseases. The fact of scarce liver resources makes the organ assigning crucial. Model for End-stage Liver Disease (MELD) score is a widely adopted criterion when making…

Artificial Intelligence · Computer Science 2023-02-21 Sirui Ding , Ruixiang Tang , Daochen Zha , Na Zou , Kai Zhang , Xiaoqian Jiang , Xia Hu

While deep neural networks (DNNs) have become a standard architecture for many machine learning tasks, their internal decision-making process and general interpretability is still poorly understood. Conversely, common decision trees are…

Machine Learning · Computer Science 2022-02-02 Coenraad Mouton , Marelie H. Davel

High-dimensional policies, such as those represented by neural networks, cannot be reasonably interpreted by humans. This lack of interpretability reduces the trust users have in policy behavior, limiting their use to low-impact tasks such…

Machine Learning · Computer Science 2021-09-20 John Mern , Sidhart Krishnan , Anil Yildiz , Kyle Hatch , Mykel J. Kochenderfer

Rationing of healthcare resources is a challenging decision that policy makers and providers may be forced to make during a pandemic, natural disaster, or mass casualty event. Well-defined guidelines to triage scarce life-saving resources…

Machine Learning · Computer Science 2024-11-12 Julien Grand-Clément , You Hui Goh , Carri Chan , Vineet Goyal , Elizabeth Chuang

Machine learning solutions for pattern classification problems are nowadays widely deployed in society and industry. However, the lack of transparency and accountability of most accurate models often hinders their safe use. Thus, there is a…

Machine Learning · Computer Science 2021-12-24 Gonzalo Nápoles , Yamisleydi Salgueiro , Isel Grau , Maikel Leon Espinosa

Understanding how deep learning models predict oncology patient risk can provide critical insights into disease progression, support clinical decision-making, and pave the way for trustworthy and data-driven precision medicine. Building on…

Computer Vision and Pattern Recognition · Computer Science 2024-11-13 Marvin Sextro , Gabriel Dernbach , Kai Standvoss , Simon Schallenberg , Frederick Klauschen , Klaus-Robert Müller , Maximilian Alber , Lukas Ruff

Life expectancy is a fundamental indicator of population health and socio-economic well-being, yet accurately forecasting it remains challenging due to the interplay of demographic, environmental, and healthcare factors. This study…

Machine Learning · Computer Science 2025-10-02 Roman Dolgopolyi , Ioanna Amaslidou , Agrippina Margaritou

This paper explores interpretability techniques for two of the most successful learning algorithms in medical decision-making literature: deep neural networks and random forests. We applied these algorithms in a real-world medical dataset…

Machine Learning · Computer Science 2020-02-24 Catarina Moreira , Renuka Sindhgatta , Chun Ouyang , Peter Bruza , Andreas Wichert
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