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With the tremendous increase in the amount of biological literature, developing automated methods for extracting big data from papers, building models and explaining big mechanisms becomes a necessity. We describe here our approach to…

Molecular Networks · Quantitative Biology 2017-06-14 Khaled Sayed , Cheryl A. Telmer , Adam A. Butchy , Natasa Miskov-Zivanov

We tackle the problem of building explainable recommendation systems that are based on a per-user decision tree, with decision rules that are based on single attribute values. We build the trees by applying learned regression functions to…

Machine Learning · Computer Science 2019-12-20 Eyal Shulman , Lior Wolf

Network intrusion detection (NID) systems which leverage machine learning have been shown to have strong performance in practice when used to detect malicious network traffic. Decision trees in particular offer a strong balance between…

Computation and Language · Computer Science 2023-10-31 Noah Ziems , Gang Liu , John Flanagan , Meng Jiang

Decision lists (DLs) find a wide range of uses for classification problems in Machine Learning (ML), being implemented in a number of ML frameworks. DLs are often perceived as interpretable. However, building on recent results for decision…

Artificial Intelligence · Computer Science 2021-05-17 Alexey Ignatiev , Joao Marques-Silva

The success of neural networks comes hand in hand with a desire for more interpretability. We focus on text classifiers and make them more interpretable by having them provide a justification, a rationale, for their predictions. We approach…

Computation and Language · Computer Science 2020-06-22 Jasmijn Bastings , Wilker Aziz , Ivan Titov

We introduce the Learning Hyperplane Tree (LHT), a novel oblique decision tree model designed for expressive and interpretable classification. LHT fundamentally distinguishes itself through a non-iterative, statistically-driven approach to…

Machine Learning · Computer Science 2025-05-08 Hongyi Li , Jun Xu , William Ward Armstrong

Latent tree learning(LTL) methods learn to parse sentences using only indirect supervision from a downstream task. Recent advances in latent tree learning have made it possible to recover moderately high quality tree structures by training…

Computation and Language · Computer Science 2019-09-24 Phu Mon Htut , Kyunghyun Cho , Samuel R. Bowman

Decision-making processes in healthcare can be highly complex and challenging. Machine Learning tools offer significant potential to assist in these processes. However, many current methodologies rely on complex models that are not easily…

Artificial Intelligence · Computer Science 2025-03-24 Alessio Cascione , Mattia Setzu , Federico A. Galatolo , Mario G. C. A. Cimino , Riccardo Guidotti

When we deploy machine learning models in high-stakes medical settings, we must ensure these models make accurate predictions that are consistent with known medical science. Inherently interpretable networks address this need by explaining…

Computer Vision and Pattern Recognition · Computer Science 2021-10-06 Alina Jade Barnett , Fides Regina Schwartz , Chaofan Tao , Chaofan Chen , Yinhao Ren , Joseph Y. Lo , Cynthia Rudin

OthelloGPT, a transformer trained to predict valid moves in Othello, provides an ideal testbed for interpretability research. The model is complex enough to exhibit rich computational patterns, yet grounded in rule-based game logic that…

Machine Learning · Computer Science 2025-11-04 Aditya Singh , Zihang Wen , Srujananjali Medicherla , Adam Karvonen , Can Rager

Decision tree models, including random forests and gradient-boosted decision trees, are widely used in machine learning due to their high predictive performance. However, their complex structures often make them difficult to interpret,…

Artificial Intelligence · Computer Science 2026-01-08 Akihiro Takemura , Masayuki Otani , Katsumi Inoue

In order to develop reliable services using machine learning, it is important to understand the uncertainty of the model outputs. Often the probability distribution that the prediction target follows has a complex shape, and a mixture…

Machine Learning · Computer Science 2021-05-11 Ryuichi Kanoh , Tomu Yanabe

Liver transplantation is a life-saving procedure for patients with end-stage liver disease. There are two main challenges in liver transplant: finding the best matching patient for a donor and ensuring transplant equity among different…

Machine Learning · Computer Science 2024-03-04 Can Li , Xiaoqian Jiang , Kai Zhang

Interpretability is crucial for doctors, hospitals, pharmaceutical companies and biotechnology corporations to analyze and make decisions for high stakes problems that involve human health. Tree-based methods have been widely adopted for…

Machine Learning · Computer Science 2024-05-24 Rui Zhang , Rui Xin , Margo Seltzer , Cynthia Rudin

This paper introduces a novel tree-based model, Learning Hyperplane Tree (LHT), which outperforms state-of-the-art (SOTA) tree models for classification tasks on several public datasets. The structure of LHT is simple and efficient: it…

Machine Learning · Computer Science 2025-01-16 Hongyi Li , Jun Xu , William Ward Armstrong

There is a need of ensuring machine learning models that are interpretable. Higher interpretability of the model means easier comprehension and explanation of future predictions for end-users. Further, interpretable machine learning models…

Machine Learning · Computer Science 2020-08-17 Gregor Stiglic , Primoz Kocbek , Nino Fijacko , Marinka Zitnik , Katrien Verbert , Leona Cilar

In healthcare there is a pursuit for employing interpretable algorithms to assist healthcare professionals in several decision scenarios. Following the Predictive, Descriptive and Relevant (PDR) framework, the definition of interpretable…

Nowadays, deep neural networks are being used in many domains because of their high accuracy results. However, they are considered as "black box", means that they are not explainable for humans. On the other hand, in some tasks such as…

Machine Learning · Computer Science 2022-04-08 Niloofar Ranjbar , Reza Safabakhsh

Interpretability of machine learning models is critical for data-driven precision medicine efforts. However, highly predictive models are generally complex and are difficult to interpret. Here using Model-Agnostic Explanations algorithm, we…

Quantitative Methods · Quantitative Biology 2016-10-31 Gajendra Jung Katuwal , Robert Chen

Decision trees are ubiquitous in machine learning for their ease of use and interpretability. Yet, these models are not typically employed in reinforcement learning as they cannot be updated online via stochastic gradient descent. We…

Machine Learning · Computer Science 2020-06-29 Andrew Silva , Taylor Killian , Ivan Dario Jimenez Rodriguez , Sung-Hyun Son , Matthew Gombolay