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Speech is a critical biomarker for Huntington Disease (HD), with changes in speech increasing in severity as the disease progresses. Speech analyses are currently conducted using either transcriptions created manually by trained…

Audio and Speech Processing · Electrical Eng. & Systems 2020-08-11 Matthew Perez , Wenyu Jin , Duc Le , Noelle Carlozzi , Praveen Dayalu , Angela Roberts , Emily Mower Provost

Huntington disease (HD) is a fatal autosomal dominant neurocognitive disorder that causes cognitive disturbances, neuropsychiatric symptoms, and impaired motor abilities (e.g., gait, speech, voice). Due to its progressive nature, HD…

Audio and Speech Processing · Electrical Eng. & Systems 2020-10-20 Amrit Romana , John Bandon , Noelle Carlozzi , Angela Roberts , Emily Mower Provost

Automatic speech recognition (ASR) for pathological speech remains underexplored, especially for Huntington's disease (HD), where irregular timing, unstable phonation, and articulatory distortion challenge current models. We present a…

Machine Learning · Computer Science 2026-03-13 Charles L. Wang , Cady Chen , Ziwei Gong , Julia Hirschberg

Disease-modifying treatments are currently assessed in neurodegenerative diseases. Huntington's Disease represents a unique opportunity to design automatic sub-clinical markers, even in premanifest gene carriers. We investigated phonatory…

Audio and Speech Processing · Electrical Eng. & Systems 2020-08-03 Rachid Riad , Hadrien Titeux , Laurie Lemoine , Justine Montillot , Jennifer Hamet Bagnou , Xuan Nga Cao , Emmanuel Dupoux , Anne-Catherine Bachoud-Lévi

One of the symptoms observed in the early stages of Parkinson's Disease (PD) is speech impairment. Speech disorders can be used to detect this disease before it degenerates. This work analyzes speech features and machine learning approaches…

Audio and Speech Processing · Electrical Eng. & Systems 2021-11-22 Adedolapo Aishat Toye , Suryaprakash Kompalli

This study investigates the speech articulatory coordination in schizophrenia subjects exhibiting strong positive symptoms (e.g. hallucinations and delusions), using two distinct channel-delay correlation methods. We show that the…

Audio and Speech Processing · Electrical Eng. & Systems 2023-05-18 Yashish M. Siriwardena , Chris Kitchen , Deanna L. Kelly , Carol Espy-Wilson

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder characterized by motor dysfunction, psychiatric disturbances, and cognitive decline. The onset of HD is marked by severe motor impairment, which may be predicted…

Methodology · Statistics 2026-02-17 Yue Zhan , Cheng Zheng , Ying Zhang

Hypernasality is a common characteristic symptom across many motor-speech disorders. For voiced sounds, hypernasality introduces an additional resonance in the lower frequencies and, for unvoiced sounds, there is reduced articulatory…

Audio and Speech Processing · Electrical Eng. & Systems 2020-09-14 Michael Saxon , Ayush Tripathi , Yishan Jiao , Julie Liss , Visar Berisha

Conventionally, the manner of articulations in speech signal are derived using discriminative signal processing techniques or deep learning approaches. However, training such complex systems involves feature extraction, phoneme force…

Audio and Speech Processing · Electrical Eng. & Systems 2018-11-06 Pradeep R , Sreenivasa Rao K

Objective: This study aimed to evaluate which voice features can predict health deterioration in patients with chronic HF. Background: Heart failure (HF) is a chronic condition with progressive deterioration and acute decompensations, often…

Multi-resolution spectro-temporal features of a speech signal represent how the brain perceives sounds by tuning cortical cells to different spectral and temporal modulations. These features produce a higher dimensional representation of…

Audio and Speech Processing · Electrical Eng. & Systems 2022-06-28 Rahil Parikh , Nadee Seneviratne , Ganesh Sivaraman , Shihab Shamma , Carol Espy-Wilson

For Huntington disease, identification of brain regions related to motor impairment can be useful for developing interventions to alleviate the motor symptom, the major symptom of the disease. However, the effects from the brain regions to…

Methodology · Statistics 2020-07-14 Rakheon Kim , Samuel Mueller , Tanya P. Garcia

Multimodal depression classification has gained immense popularity over the recent years. We develop a multimodal depression classification system using articulatory coordination features extracted from vocal tract variables and text…

Audio and Speech Processing · Electrical Eng. & Systems 2022-02-15 Nadee Seneviratne , Carol Espy-Wilson

This paper presents a widespread analysis of affective vocal expression classification systems. In this study, state-of-the-art acoustic features are compared to two novel affective vocal prints for the detection of emotional states: the…

Audio and Speech Processing · Electrical Eng. & Systems 2019-10-07 V. Vieira , R. Coelho , F. Assis

Automated detection of voice disorders with computational methods is a recent research area in the medical domain since it requires a rigorous endoscopy for the accurate diagnosis. Efficient screening methods are required for the diagnosis…

Quantitative Methods · Quantitative Biology 2018-12-06 Vibhuti Gupta

Imprecise vowel articulation can be observed in people with Parkinson's disease (PD). Acoustic features measuring vowel articulation have been demonstrated to be effective indicators of PD in its assessment. Standard clinical vowel…

Audio and Speech Processing · Electrical Eng. & Systems 2021-08-18 Yuanyuan Liu , Nelly Penttilä , Tiina Ihalainen , Juulia Lintula , Rachel Convey , Okko Räsänen

This study investigates the speech articulatory coordination in schizophrenia subjects exhibiting strong positive symptoms (e.g.hallucinations and delusions), using a time delay embedded correlation analysis. We show that the schizophrenia…

Audio and Speech Processing · Electrical Eng. & Systems 2021-02-16 Yashish Maduwantha H. P. E. R. S , Chris Kitchen , Deanna L. Kelly , Carol Espy-Wilson

Stuttering is a complex speech disorder that can be identified by repetitions, prolongations of sounds, syllables or words, and blocks while speaking. Severity assessment is usually done by a speech therapist. While attempts at automated…

Quantitative Methods · Quantitative Biology 2020-06-17 Sebastian P. Bayerl , Florian Hönig , Joelle Reister , Korbinian Riedhammer

The incidence rate of voice diseases is increasing year by year. The use of software for remote diagnosis is a technical development trend and has important practical value. Among voice diseases, common diseases that cause hoarseness…

Sound · Computer Science 2023-04-19 Xiaoping Xie , Hao Cai , Can Li , Fei Ding

This paper integrates a voice activity detection (VAD) function with end-to-end automatic speech recognition toward an online speech interface and transcribing very long audio recordings. We focus on connectionist temporal classification…

Audio and Speech Processing · Electrical Eng. & Systems 2020-03-16 Takenori Yoshimura , Tomoki Hayashi , Kazuya Takeda , Shinji Watanabe
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