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Over the past few years, we have seen fundamental breakthroughs in core problems in machine learning, largely driven by advances in deep neural networks. At the same time, the amount of data collected in a wide array of scientific domains…

Machine Learning · Computer Science 2020-03-27 Maithra Raghu , Eric Schmidt

Deep Learning (DL) methods have dramatically increased in popularity in recent years, with significant growth in their application to supervised learning problems in the biomedical sciences. However, the greater prevalence and complexity of…

Machine Learning · Statistics 2023-10-30 David K Lim , Naim U Rashid , Junier B Oliva , Joseph G Ibrahim

Significance: Optical neuroimaging has become a well-established clinical and research tool to monitor cortical activations in the human brain. It is notable that outcomes of functional Near-InfraRed Spectroscopy (fNIRS) studies depend…

Neurons and Cognition · Quantitative Biology 2023-01-03 Condell Eastmond , Aseem Subedi , Suvranu De , Xavier Intes

Deep Learning (DL) models have achieved superior performance in many application domains, including vision, language, medical, commercial ads, entertainment, etc. With the fast development, both DL applications and the underlying serving…

Machine Learning · Computer Science 2022-02-22 Fuxun Yu , Di Wang , Longfei Shangguan , Minjia Zhang , Xulong Tang , Chenchen Liu , Xiang Chen

Single-cell analysis is currently one of the most high-resolution techniques to study biology. The large complex datasets that have been generated have spurred numerous developments in computational biology, in particular the use of…

Genomics · Quantitative Biology 2023-04-27 Ionut Sebastian Mihai , Sarang Chafle , Johan Henriksson

The existence of doublets in single-cell RNA sequencing (scRNA-seq) data poses a great challenge in downstream data analysis. Computational doublet-detection methods have been developed to remove doublets from scRNA-seq data. Yet, the…

Quantitative Methods · Quantitative Biology 2023-02-07 Nan Miles Xi , Angelos Vasilopoulos

Identifying cell clusters is a critical step for single-cell transcriptomics study. Despite the numerous clustering tools developed recently, the rapid growth of scRNA-seq volumes prompts for a more (computationally) efficient clustering…

Quantitative Methods · Quantitative Biology 2023-01-11 Nana Wei , Yating Nie , Lin Liu , Xiaoqi Zheng , Hua-Jun Wu4

Single-cell RNA sequencing (scRNA-seq) enables dissecting cellular heterogeneity in tissues, resulting in numerous biological discoveries. Various computational methods have been devised to delineate cell types by clustering scRNA-seq data…

Quantitative Methods · Quantitative Biology 2023-09-18 Tram Huynh , Zixuan Cang

Recent years, deep learning is increasingly prevalent in the field of Software Engineering (SE). However, many open issues still remain to be investigated. How do researchers integrate deep learning into SE problems? Which SE phases are…

Software Engineering · Computer Science 2018-05-15 Xiaochen Li , He Jiang , Zhilei Ren , Ge Li , Jingxuan Zhang

Skin cancer is one of the most prevalent and deadly forms of cancer worldwide, highlighting the critical importance of early detection and diagnosis in improving patient outcomes. Deep learning (DL) has shown significant promise in…

Computer Vision and Pattern Recognition · Computer Science 2026-01-19 Runhao Liu , Ziming Chen , Guangzhen Yao , Peng Zhang

Context: Automated software defect prediction (SDP) methods are increasingly applied, often with the use of machine learning (ML) techniques. Yet, the existing ML-based approaches require manually extracted features, which are cumbersome,…

Software Engineering · Computer Science 2022-10-06 Görkem Giray , Kwabena Ebo Bennin , Ömer Köksal , Önder Babur , Bedir Tekinerdogan

Deep learning, a branch of artificial intelligence, is a data-driven method that uses multiple layers of interconnected units or neurons to learn intricate patterns and representations directly from raw input data. Empowered by this…

Machine Learning · Computer Science 2025-07-28 Mohd Halim Mohd Noor , Ayokunle Olalekan Ige

Active learning seeks to achieve strong performance with fewer training samples. It does this by iteratively asking an oracle to label new selected samples in a human-in-the-loop manner. This technique has gained increasing popularity due…

Machine Learning · Computer Science 2024-07-16 Dongyuan Li , Zhen Wang , Yankai Chen , Renhe Jiang , Weiping Ding , Manabu Okumura

The cell cycle is one of the most fundamental biological processes important for understanding normal physiology and various pathologies such as cancer. Single cell RNA sequencing technologies give an opportunity to analyse the cell cycle…

Quantitative Methods · Quantitative Biology 2022-08-11 Alexander Chervov , Andrei Zinovyev

Since 2009, the deep learning revolution, which was triggered by the introduction of ImageNet, has stimulated the synergy between Machine Learning (ML)/Deep Learning (DL) and Software Engineering (SE). Meanwhile, critical reviews have…

Software Engineering · Computer Science 2020-08-14 Simin Wang , Liguo Huang , Jidong Ge , Tengfei Zhang , Haitao Feng , Ming Li , He Zhang , Vincent Ng

Single-cell RNA sequencing (scRNA-seq) reveals cell heterogeneity, with cell clustering playing a key role in identifying cell types and marker genes. Recent advances, especially graph neural networks (GNNs)-based methods, have…

Genomics · Quantitative Biology 2025-10-03 Ping Xu , Zhiyuan Ning , Pengjiang Li , Wenhao Liu , Pengyang Wang , Jiaxu Cui , Yuanchun Zhou , Pengfei Wang

Single-cell RNA sequencing provides tremendous insights to understand biological systems. However, the noise from dropout can corrupt the downstream biological analysis. Hence, it is desirable to impute the dropouts accurately. In this…

Quantitative Methods · Quantitative Biology 2020-08-11 Kexin Huang

In recent years, the field of single-cell data analysis has seen a marked advancement in the development of clustering methods. Despite advancements, most of these algorithms still concentrate on analyzing the provided single-cell matrix…

Machine Learning · Computer Science 2023-12-18 Dayu Hu , Ke Liang , Hao Yu , Xinwang Liu

Pruning the parameters and structure of neural networks reduces the computational complexity, energy consumption, and latency during inference. Recently, a novel underlying mechanism for successful deep learning (DL) was presented based on…

Machine Learning · Computer Science 2025-06-13 Yarden Tzach , Yuval Meir , Ronit D. Gross , Ofek Tevet , Ella Koresh , Ido Kanter

Deep Learning (DL) algorithms hold great promise for applications in the field of computational biophysics. In fact, the vast amount of available molecular structures, as well as their notable complexity, constitutes an ideal context in…

Soft Condensed Matter · Physics 2019-01-07 Marco Giulini , Raffaello Potestio
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