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Related papers: Can Language Models be Biomedical Knowledge Bases?

200 papers

Drug repurposing is often framed as a candidate identification task, but existing approaches provide limited guidance for distinguishing biologically plausible candidates from historically well-connected ones. Here we introduce DrugKLM, a…

There is increasing interest in the application large language models (LLMs) to the medical field, in part because of their impressive performance on medical exam questions. While promising, exam questions do not reflect the complexity of…

Knowledge-enhanced Pre-trained Language Model (PLM) has recently received significant attention, which aims to incorporate factual knowledge into PLMs. However, most existing methods modify the internal structures of fixed types of PLMs by…

Computation and Language · Computer Science 2022-10-18 Jianing Wang , Wenkang Huang , Qiuhui Shi , Hongbin Wang , Minghui Qiu , Xiang Li , Ming Gao

Language models often struggle with handling factual knowledge, exhibiting factual hallucination issue. This makes it vital to evaluate the models' ability to recall its parametric knowledge about facts. In this study, we introduce a…

Computation and Language · Computer Science 2024-10-10 Xin Zhao , Naoki Yoshinaga , Daisuke Oba

As LLMs have become increasingly popular, they have been used in almost every field. But as the application for LLMs expands from generic fields to narrow, focused science domains, there exists an ever-increasing gap in ways to evaluate…

Computation and Language · Computer Science 2023-10-18 Anurag Acharya , Sai Munikoti , Aaron Hellinger , Sara Smith , Sridevi Wagle , Sameera Horawalavithana

The rapid growth of biomedical literature poses challenges for manual knowledge curation and synthesis. Biomedical Natural Language Processing (BioNLP) automates the process. While Large Language Models (LLMs) have shown promise in general…

We present a systematic study of medical-domain interpretability in Large Language Models (LLMs). We study how the LLMs both represent and process medical knowledge through four different interpretability techniques: (1) UMAP projections of…

Machine Learning · Computer Science 2026-02-24 Razvan Marinescu , Victoria-Elisabeth Gruber , Diego Fajardo

Large pre-trained language models have demonstrated their proficiency in storing factual knowledge within their parameters and achieving remarkable results when fine-tuned for downstream natural language processing tasks. Nonetheless, their…

Computation and Language · Computer Science 2023-09-29 Konstantinos Andriopoulos , Johan Pouwelse

Large-scale knowledge bases (KBs) like Freebase and Wikidata house millions of structured knowledge. Knowledge Base Question Answering (KBQA) provides a user-friendly way to access these valuable KBs via asking natural language questions.…

Computation and Language · Computer Science 2024-06-24 Lingxi Zhang , Jing Zhang , Yanling Wang , Cuiping Li , Hong Chen

Large language models (LLMs) have made significant progress in various domains, including healthcare. However, the specialized nature of clinical language understanding tasks presents unique challenges and limitations that warrant further…

Computation and Language · Computer Science 2023-08-01 Yuqing Wang , Yun Zhao , Linda Petzold

Knowledge Base Question Answering (KBQA) aims to answer natural language questions based on facts in knowledge bases. A typical approach to KBQA is semantic parsing, which translates a question into an executable logical form in a formal…

Computation and Language · Computer Science 2024-06-17 Jinxin Liu , Shulin Cao , Jiaxin Shi , Tingjian Zhang , Lunyiu Nie , Linmei Hu , Lei Hou , Juanzi Li

Recent work has presented intriguing results examining the knowledge contained in language models (LM) by having the LM fill in the blanks of prompts such as "Obama is a _ by profession". These prompts are usually manually created, and…

Computation and Language · Computer Science 2020-05-05 Zhengbao Jiang , Frank F. Xu , Jun Araki , Graham Neubig

Language models (LLMs) offer potential as a source of knowledge for agents that need to acquire new task competencies within a performance environment. We describe efforts toward a novel agent capability that can construct cues (or…

Machine Learning · Computer Science 2022-11-22 James R. Kirk , Robert E. Wray , Peter Lindes , John E. Laird

Large Language Models (LLMs) have demonstrated surprising performance across various natural language processing tasks. Recently, medical LLMs enhanced with domain-specific knowledge have exhibited excellent capabilities in medical…

Computation and Language · Computer Science 2024-09-24 Jinqiang Wang , Huansheng Ning , Yi Peng , Qikai Wei , Daniel Tesfai , Wenwei Mao , Tao Zhu , Runhe Huang

Automatic relationship extraction (RE) from biomedical literature is critical for managing the vast amount of scientific knowledge produced each year. In recent years, utilizing pre-trained language models (PLMs) has become the prevalent…

Computation and Language · Computer Science 2025-11-04 Mario Sänger , Ulf Leser

Large language models (LLMs) have learned vast amounts of factual knowledge through self-supervised pre-training on large-scale corpora. Meanwhile, LLMs have also demonstrated excellent multilingual capabilities, which can express the…

Computation and Language · Computer Science 2024-11-27 Pengfei Cao , Yuheng Chen , Zhuoran Jin , Yubo Chen , Kang Liu , Jun Zhao

Large language models exhibit promising general capabilities but often lack specialized knowledge for domain-specific tasks. Developing domain experts from a base model enables a range of applications without prohibitive training costs.…

Computation and Language · Computer Science 2023-11-02 Zhen Guo , Yining Hua

Large language models (LLMs) have demonstrated immense capabilities in understanding textual data and are increasingly being adopted to help researchers accelerate scientific discovery through knowledge extraction (information retrieval),…

Computer Vision and Pattern Recognition · Computer Science 2025-05-30 Robinson Umeike , Neil Getty , Fangfang Xia , Rick Stevens

Large language models (LLMs) have recently emerged as powerful tools, finding many medical applications. LLMs' ability to coalesce vast amounts of information from many sources to generate a response-a process similar to that of a human…

Transformer-based language models (LMs) continue to achieve state-of-the-art performance on natural language processing (NLP) benchmarks, including tasks designed to mimic human-inspired "commonsense" competencies. To better understand the…

Computation and Language · Computer Science 2022-05-13 Antonio Laverghetta , Animesh Nighojkar , Jamshidbek Mirzakhalov , John Licato