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We present an efficient classical algorithm for training deep Boltzmann machines (DBMs) that uses rejection sampling in concert with variational approximations to estimate the gradients of the training objective function. Our algorithm is…

Machine Learning · Computer Science 2015-07-10 Nathan Wiebe , Ashish Kapoor , Christopher Granade , Krysta M Svore

The performance of deep neural networks, such as Deep Belief Networks formed by Restricted Boltzmann Machines (RBMs), strongly depends on their training, which is the process of adjusting their parameters. This process can be posed as an…

Neural and Evolutionary Computing · Computer Science 2019-07-16 S. Ivvan Valdez , Alfonso Rojas-Domínguez

Finding reduced models of spatially-distributed chemical reaction networks requires an estimation of which effective dynamics are relevant. We propose a machine learning approach to this coarse graining problem, where a maximum entropy…

Biological Physics · Physics 2018-08-15 Oliver K. Ernst , Thomas Bartol , Terrence Sejnowski , Eric Mjolsness

It is widely known that Boltzmann machines are capable of representing arbitrary probability distributions over the values of their visible neurons, given enough hidden ones. However, sampling -- and thus training -- these models can be…

We introduce a Deep Boltzmann Machine model suitable for modeling and extracting latent semantic representations from a large unstructured collection of documents. We overcome the apparent difficulty of training a DBM with judicious…

Machine Learning · Computer Science 2013-09-27 Nitish Srivastava , Ruslan R Salakhutdinov , Geoffrey E. Hinton

Many computer vision applications involve modeling complex spatio-temporal patterns in high-dimensional motion data. Recently, restricted Boltzmann machines (RBMs) have been widely used to capture and represent spatial patterns in a single…

Computer Vision and Pattern Recognition · Computer Science 2017-10-24 Siqi Nie , Ziheng Wang , Qiang Ji

The paper focuses on the a posteriori tuning of a generative model in order to favor the generation of good instances in the sense of some external differentiable criterion. The proposed approach, called Boltzmann Tuning of Generative…

Artificial Intelligence · Computer Science 2021-04-13 Victor Berger , Michele Sebag

Deep Learning has a hierarchical network architecture to represent the complicated feature of input patterns. The adaptive structural learning method of Deep Belief Network (DBN) has been developed. The method can discover an optimal number…

Neural and Evolutionary Computing · Computer Science 2018-08-28 Shin Kamada , Takumi Ichimura , Toshihide Harada

We present the Boltzmann classifier, a novel distance based probabilistic classification algorithm inspired by the Boltzmann distribution. Unlike traditional classifiers that produce hard decisions or uncalibrated probabilities, the…

Machine Learning · Computer Science 2025-06-23 Muhamed Amin , Bernard R. Brooks

Sequences of nucleotides (for DNA and RNA) or amino acids (for proteins) are central objects in biology. Among the most important computational problems is that of sequence alignment, i.e. arranging sequences from different organisms in…

Quantitative Methods · Quantitative Biology 2020-12-08 Anna Paola Muntoni , Andrea Pagnani , Martin Weigt , Francesco Zamponi

Restricted Boltzmann Machine (RBM) is a generative stochastic energy-based model of artificial neural network for unsupervised learning. Recently, RBM is well known to be a pre-training method of Deep Learning. In addition to visible and…

Neural and Evolutionary Computing · Computer Science 2018-07-12 Shin Kamada , Takumi Ichimura

Boltzmann machines (BM) are widely used as generative models. For example, pairwise Potts models (PM), which are instances of the BM class, provide accurate statistical models of families of evolutionarily related protein sequences. Their…

Biomolecules · Quantitative Biology 2021-08-09 Pierre Barrat-Charlaix , Anna Paola Muntoni , Kai Shimagaki , Martin Weigt , Francesco Zamponi

Generative models offer a direct way of modeling complex data. Energy-based models attempt to encode the statistical correlations observed in the data at the level of the Boltzmann weight associated with an energy function in the form of a…

Disordered Systems and Neural Networks · Physics 2024-04-10 Aurélien Decelle , Cyril Furtlehner , Alfonso De Jesus Navas Gómez , Beatriz Seoane

Transfer Learning is concerned with the application of knowledge gained from solving a problem to a different but related problem domain. In this paper, we propose a method and efficient algorithm for ranking and selecting representations…

Machine Learning · Computer Science 2014-05-29 Son N. Tran , Artur d'Avila Garcez

Structure-based drug design (SBDD) aims to generate 3D ligand molecules that bind to specific protein targets. Existing 3D deep generative models including diffusion models have shown great promise for SBDD. However, it is complex to…

Biomolecules · Quantitative Biology 2024-03-01 Zhilin Huang , Ling Yang , Zaixi Zhang , Xiangxin Zhou , Yu Bao , Xiawu Zheng , Yuwei Yang , Yu Wang , Wenming Yang

In many real-world datasets, rows may have distinct characteristics and require different modeling approaches for accurate predictions. In this paper, we propose an adaptive modeling approach for row-type dependent predictive…

Machine Learning · Computer Science 2023-11-21 Minati Rath , Hema Date

Lattice-Boltzmann methods are known for their simplicity, efficiency and ease of parallelization, usually relying on uniform Cartesian meshes with a strong bond between spatial and temporal discretization. This fact complicates the crucial…

Numerical Analysis · Mathematics 2022-10-19 Thomas Bellotti , Loïc Gouarin , Benjamin Graille , Marc Massot

We present a new method to extract distance and orientation dependent potentials between amino acid side chains using a database of protein structures and the standard Boltzmann device. The importance of orientation dependent interactions…

Chemical Physics · Physics 2016-09-08 N. -V. Buchete , J. E. Straub , D. Thirumalai

The "interpretation through synthesis" approach to analyze face images, particularly Active Appearance Models (AAMs) method, has become one of the most successful face modeling approaches over the last two decades. AAM models have ability…

Computer Vision and Pattern Recognition · Computer Science 2021-06-08 Chi Nhan Duong , Khoa Luu , Kha Gia Quach , Tien D. Bui

A restricted Boltzmann machine (RBM) is an undirected graphical model constructed for discrete or continuous random variables, with two layers, one hidden and one visible, and no conditional dependency within a layer. In recent years, RBMs…

Machine Learning · Statistics 2019-09-12 Andee Kaplan , Daniel Nordman , Stephen Vardeman