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In silico prediction of cardiotoxicity with high sensitivity and specificity for potential drug molecules can be of immense value. Hence, building machine learning classification models, based on some features extracted from the molecular…

Quantitative Methods · Quantitative Biology 2021-06-09 Aditya Sarkar , Arnav Bhavsar

Worldwide, many millions of people die suddenly and unexpectedly each year, either with or without a prior history of cardiovascular disease. Such events are sparse (once in a lifetime), many victims will not have had prior investigations…

Machine Learning · Computer Science 2023-09-06 Yola Jones , Fani Deligianni , Jeff Dalton , Pierpaolo Pellicori , John G F Cleland

learning algorithms. In this paper, we review the classification algorithms used in the health care system (chronic diseases) and present the neural network-based Ensemble learning method. We briefly describe the commonly used algorithms…

Machine Learning · Computer Science 2021-03-16 Jafar Abdollahi , Babak Nouri-Moghaddam , Mehdi Ghazanfari

In medical science, it is very important to gather multiple data on different diseases and one of the most important objectives of the data is to investigate the diseases. Myocardial infarction is a serious risk factor in mortality and in…

Machine Learning · Computer Science 2021-12-16 Tanya Aghazadeh , Mostafa Bagheri

We develop and analyze explainable machine learning (ML) models for sepsis outcome prediction using a novel Electronic Health Record (EHR) dataset from 12,286 hospitalizations at a large emergency hospital in Romania. The dataset includes…

Machine Learning · Computer Science 2026-04-07 Andrei-Alexandru Bunea , Ovidiu Ghibea , Dan-Matei Popovici , Ion Daniel , Octavian Andronic

Predicting the incidence of complex chronic conditions such as heart failure is challenging. Deep learning models applied to rich electronic health records may improve prediction but remain unexplainable hampering their wider use in medical…

Predictive modelling is vital to guide preventive efforts. Whilst large-scale prospective cohort studies and a diverse toolkit of available machine learning (ML) algorithms have facilitated such survival task efforts, choosing the…

Patients resuscitated from cardiac arrest (CA) face a high risk of neurological disability and death, however pragmatic methods are lacking for accurate and reliable prognostication. The aim of this study was to build computational models…

Over the last decades, many prognostic models based on artificial intelligence techniques have been used to provide detailed predictions in healthcare. Unfortunately, the real-world observational data used to train and validate these models…

Machine Learning · Computer Science 2023-11-21 Alice Bernasconi , Alessio Zanga , Peter J. F. Lucas , Marco Scutari , Fabio Stella

Credit risk default prediction remains a cornerstone of risk management in the financial industry. The task involves estimating the likelihood that a borrower will fail to meet debt obligations, an objective critical for lending decisions,…

Machine Learning · Computer Science 2026-04-21 Swattik Maiti , Ritik Pratap Singh , Fardina Fathmiul Alam

Chronic diseases are long-lasting conditions that require lifelong medical attention. Using big EMR data, we have developed early disease risk prediction models for five common chronic diseases: diabetes, hypertension, CKD, COPD, and…

Machine Learning · Computer Science 2026-03-13 Shaheer Ahmad Khan , Muhammad Usamah Shahid , Muddassar Farooq

Background: Stroke is second-leading cause of disability and death among adults. Approximately 17 million people suffer from a stroke annually, with about 85% being ischemic strokes. Predicting mortality of ischemic stroke patients in…

Machine Learning · Computer Science 2024-09-04 Armin Abdollahi , Negin Ashrafi , Maryam Pishgar

In this paper ensemble learning based feature selection and classifier ensemble model is proposed to improve classification accuracy. The hypothesis is that good feature sets contain features that are highly correlated with the class from…

Machine Learning · Computer Science 2020-10-28 Tipawan Silwattananusarn , Wanida Kanarkard , Kulthida Tuamsuk

The COVID-19 pandemic has significantly increased the incidence of post-infection cardiovascular events, particularly myocardial infarction, in individuals over 40. While the underlying mechanisms remain elusive, this study employs a hybrid…

Populations and Evolution · Quantitative Biology 2025-05-28 Subhagata Chattopadhyay , Amit K Chattopadhyay

Healthcare is one of the most important aspects of human life. Heart disease is known to be one of the deadliest diseases which is hampering the lives of many people around the world. Heart disease must be detected early so the loss of…

Machine Learning · Computer Science 2024-09-04 Shadab Hussain , Santosh Kumar Nanda , Susmith Barigidad , Shadab Akhtar , Md Suaib , Niranjan K. Ray

Although Machine Learning (ML) can be seen as a promising tool to improve clinical decision-making for supporting the improvement of medication plans, clinical procedures, diagnoses, or medication prescriptions, it remains limited by access…

In electronic health records (EHRs), clustering patients and distinguishing disease subtypes are key tasks to elucidate pathophysiology and aid clinical decision-making. However, clustering in healthcare informatics is still based on…

Machine Learning · Computer Science 2026-04-09 Manar D. Samad , Yina Hou , Shrabani Ghosh

Decisions about managing patients on the heart transplant waitlist are currently made by committees of doctors who consider multiple factors, but the process remains largely ad-hoc. With the growing volume of longitudinal patient, donor,…

Applications · Statistics 2025-07-11 Yingtao Luo , Reza Skandari , Carlos Martinez , Arman Kilic , Rema Padman

Survival analysis is a fundamental tool in medicine, modeling the time until an event of interest occurs in a population. However, in real-world applications, survival data are often incomplete, censored, distributed, and confidential,…

Machine Learning · Computer Science 2023-08-07 Alberto Archetti , Francesca Ieva , Matteo Matteucci

Performance monitoring of machine learning (ML)-based risk prediction models in healthcare is complicated by the issue of confounding medical interventions (CMI): when an algorithm predicts a patient to be at high risk for an adverse event,…

Machine Learning · Statistics 2023-04-17 Jean Feng , Alexej Gossmann , Gene Pennello , Nicholas Petrick , Berkman Sahiner , Romain Pirracchio