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Image-generative artificial intelligence (AI) has garnered significant attention in recent years. In particular, the diffusion model, a core component of generative AI, produces high-quality images with rich diversity. In this study, we…

Computer Vision and Pattern Recognition · Computer Science 2024-09-13 Sho Ozaki , Shizuo Kaji , Toshikazu Imae , Kanabu Nawa , Hideomi Yamashita , Keiichi Nakagawa

Deep learning-based reconstruction of positron emission tomography(PET) data has gained increasing attention in recent years. While these methods achieve fast reconstruction,concerns remain regarding quantitative accuracy and the presence…

We propose a new modeling approach for scatter estimation and descattering in polyenergetic X-ray computed tomography (CT) based on fitting models to local neighborhoods of a training set. X-ray CT is widely used in medical and industrial…

Image and Video Processing · Electrical Eng. & Systems 2021-09-30 Michael T. McCann , Marc L. Klasky , Jennifer L. Schei , Saiprasad Ravishankar

Current methods for magnetic resonance-based positron emission tomography attenuation correction (PET-MR AC) are time consuming, and less able than computed tomography (CT)-based AC methods to capture inter-individual variability and skull…

Cone-beam computed tomography (CBCT) has been widely used in medical imaging and industrial nondestructive testing, but the presence of scattered radiation will cause significant reduction of image quality. In this article, a robust scatter…

Medical Physics · Physics 2016-08-03 Kuidong Huang , Zhe Xu , Dinghua Zhang , Hua Zhang , Wenlong Shi

Recent work has shown improved lesion detectability and flexibility to reconstruction hyperparameters (e.g. scanner geometry or dose level) when PET images are reconstructed by leveraging pre-trained diffusion models. Such methods train a…

Medical Physics · Physics 2025-08-28 George Webber , Alexander Hammers , Andrew P. King , Andrew J. Reader

Quantitative PET attenuation correction (AC) for combined cardiac PET/MR is a challenging problem. We propose and evaluate an AC approach that uses coincidences from a relatively weak and physically fixed sparse external source, in…

Medical Physics · Physics 2023-01-02 Mi-Ae Park , Vlad G. Zaha , Ramsey D. Badawi , Spencer L. Bowen

Cancer is one of the leading causes of death worldwide. Fast and safe early-stage, pre- and intra-operative diagnostics can significantly contribute to successful cancer identification and treatment. Artificial intelligence has played an…

Tissues and Organs · Quantitative Biology 2022-08-10 Marina Zajnulina

Objective: In this work, we set out to investigate the accuracy of direct attenuation correction (AC) in the image domain for the myocardial perfusion SPECT imaging (MPI-SPECT) using two residual (ResNet) and UNet deep convolutional neural…

Computed tomography (CT)-based attenuation and scatter correction improves quantitative PET but adds radiation exposure that is particularly undesirable in pediatric imaging. Existing CT-free methods are commonly trained in homogeneous…

Image and Video Processing · Electrical Eng. & Systems 2026-04-28 Jia-Mian Wu , Jun Liu , Siqi Li , Xiaoya Wang , Shibai Yin , Huanyu Luo , Lingling Zheng , Qiang Gao , Jigang Yang , Tai-Xiang Jiang

Quantitative molecular imaging is central to treatment response assessment in oncology, yet clinical practice remains largely dominated by patient-level or limited target-lesion criteria that ignore inter-lesion heterogeneity. This…

Medical Physics · Physics 2026-03-25 Fereshteh Yousefirizi , Jean-Mathieu Beauregard , Arman Rahmim

Scatter due to interaction of photons with the imaged object is a fundamental problem in X-ray Computed Tomography (CT). It manifests as various artifacts in the reconstruction, making its abatement or correction critical for image quality.…

Medical Physics · Physics 2024-01-30 Berk Iskender , Yoram Bresler

In this work, we compare one-step and two-step approaches for X-ray computed tomography (CT) scatter correction and density reconstruction. X-ray CT is an important imaging technique in medical and industrial applications. In many cases,…

Image and Video Processing · Electrical Eng. & Systems 2023-01-11 Alexander N. Sietsema , Michael T. McCann , Marc L. Klasky , Saiprasad Ravishankar

Spectral computed tomography (CT) has recently emerged as an advanced version of medical CT and significantly improves conventional (single-energy) CT. Spectral CT has two main forms: dual-energy computed tomography (DECT) and…

We provide a fast and accurate scatter artifacts correction algorithm for cone beam CT (CBCT) imaging. The method starts with an estimation of coarse scatter profile for a set of CBCT images. A total-variation denoising algorithm designed…

Medical Physics · Physics 2015-01-20 Wei Zhao , Jun Zhu , Luyao Wang

Attenuation compensation (AC), while being beneficial for visual-interpretation tasks in myocardial perfusion imaging (MPI) by SPECT, typically requires the availability of a separate X-ray CT component, leading to additional radiation…

Artificial intelligence (AI) is entering medical imaging, mainly enhancing image reconstruction. Nevertheless, improvements throughout the entire processing, from signal detection to computation, potentially offer significant benefits. This…

Machine Learning · Computer Science 2023-10-27 Stephan Naunheim , Yannick Kuhl , David Schug , Volkmar Schulz , Florian Mueller

The escalating global cancer burden underscores the critical need for precise diagnostic tools in oncology. This research employs deep learning to enhance lesion segmentation in PET/CT imaging, utilizing a dataset of 900 whole-body…

Computer Vision and Pattern Recognition · Computer Science 2024-09-17 Jiayi Liu , Qiaoyi Xue , Youdan Feng , Tianming Xu , Kaixin Shen , Chuyun Shen , Yuhang Shi

The Compton camera is a promising alternative to the Anger camera for imaging gamma radiation, with the potential to significantly increase the sensitivity of SPECT. Two-dimensional Compton camera image reconstruction can be implemented by…

Numerical Analysis · Mathematics 2016-09-13 Markus Haltmeier , Sunghwan Moon , Daniela Schiefeneder

Recently, Artificial Intelligence (AI)-based algorithms have revolutionized the medical image segmentation processes. Thus, the precise segmentation of organs and their lesions may contribute to an efficient diagnostics process and a more…

Neurons and Cognition · Quantitative Biology 2024-03-21 Zofia Rudnicka , Janusz Szczepanski , Agnieszka Pregowska