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In histopathology, scanner-induced domain shifts are known to impede the performance of trained neural networks when tested on unseen data. Multi-domain pre-training or dedicated domain-generalization techniques can help to develop…

The MIDOG 2025 challenge extends prior work on mitotic figure detection by introducing a new Track 2 on atypical mitosis classification. This task aims to distinguish normal from atypical mitotic figures in histopathology images, a…

Image and Video Processing · Electrical Eng. & Systems 2025-09-04 Leire Benito-Del-Valle , Pedro A. Moreno-Sánchez , Itziar Egusquiza , Itsaso Vitoria , Artzai Picón , Cristina López-Saratxaga , Adrian Galdran

Change detection has essential significance for the region's development, in which pseudo-changes between bitemporal images induced by imaging environmental factors are key challenges. Existing transformation-based methods regard…

Computer Vision and Pattern Recognition · Computer Science 2025-04-02 Qi Zang , Shuang Wang , Dong Zhao , Dou Quan , Yang Hu , Licheng Jiao

Image normalization is a critical step in medical imaging. This step is often done on a per-dataset basis, preventing current segmentation algorithms from the full potential of exploiting jointly normalized information across multiple…

Machine Learning · Computer Science 2020-02-04 Pierre-Luc Delisle , Benoit Anctil-Robitaille , Christian Desrosiers , Herve Lombaert

The proliferative activity of breast tumors, which is routinely estimated by counting of mitotic figures in hematoxylin and eosin stained histology sections, is considered to be one of the most important prognostic markers. However, mitosis…

We propose a two-step domain shift-invariant mitosis cell detection method based on Faster RCNN and a convolutional neural network (CNN). We generate various domain-shifted versions of existing histopathology images using a stain…

Computer Vision and Pattern Recognition · Computer Science 2021-09-29 Ramin Nateghi , Fattaneh Pourakpour

Foundation models (FMs), i.e., models trained on a vast amount of typically unlabeled data, have become popular and available recently for the domain of histopathology. The key idea is to extract semantically rich vectors from any input…

Computer Vision and Pattern Recognition · Computer Science 2024-12-17 Jonathan Ganz , Jonas Ammeling , Emely Rosbach , Ludwig Lausser , Christof A. Bertram , Katharina Breininger , Marc Aubreville

We present a solution for the MIDOG 2025 Challenge Track~2, addressing binary classification of normal mitotic figures (NMFs) versus atypical mitotic figures (AMFs). The approach leverages pathology-specific foundation model H-optimus-0,…

Atypical mitotic figures (AMFs) are clinically relevant indicators of abnormal cell division, yet their reliable detection remains challenging due to morphological ambiguity and scanner variability. In this work, we investigated three…

Image and Video Processing · Electrical Eng. & Systems 2025-09-08 Biwen Meng , Xi Long , Jingxin Liu

Domain shift in digital histopathology can occur when different stains or scanners are used, during stain translation, etc. A deep neural network trained on source data may not generalise well to data that has undergone some domain shift.…

Image and Video Processing · Electrical Eng. & Systems 2022-05-10 Zeeshan Nisar , Jelica Vasiljević , Pierre Gançarski , Thomas Lampert

This paper addresses domain adaptation for the pixel-wise classification of remotely sensed data using deep neural networks (DNN) as a strategy to reduce the requirements of DNN with respect to the availability of training data. We focus on…

Computer Vision and Pattern Recognition · Computer Science 2021-08-18 Dennis Wittich , Franz Rottensteiner

Each woman living in the United States has about 1 in 8 chance of developing invasive breast cancer. The mitotic cell count is one of the most common tests to assess the aggressiveness or grade of breast cancer. In this prognosis,…

Computer Vision and Pattern Recognition · Computer Science 2022-02-18 Robin Elizabeth Yancey

Domain shift refers to the well known problem that a model trained in one source domain performs poorly when applied to a target domain with different statistics. {Domain Generalization} (DG) techniques attempt to alleviate this issue by…

Machine Learning · Computer Science 2017-10-11 Da Li , Yongxin Yang , Yi-Zhe Song , Timothy M. Hospedales

In AI-based histopathology, domain shifts are common and well-studied. However, this research focuses on stain and scanner variations, which do not show the full picture -- shifts may be combinations of other shifts, or "invisible" shifts…

Image and Video Processing · Electrical Eng. & Systems 2023-05-10 Andrew Walker

The problem of domain generalization is to take knowledge acquired from a number of related domains where training data is available, and to then successfully apply it to previously unseen domains. We propose a new feature learning…

Computer Vision and Pattern Recognition · Computer Science 2016-07-28 Muhammad Ghifary , W. Bastiaan Kleijn , Mengjie Zhang , David Balduzzi

This study introduces a novel framework for enhancing domain generalization in medical imaging, specifically focusing on utilizing unlabelled multi-view colour fundus photographs. Unlike traditional approaches that rely on single-view…

Computer Vision and Pattern Recognition · Computer Science 2024-03-26 Ze Chen , Gongyu Zhang , Jiayu Huo , Joan Nunez do Rio , Charalampos Komninos , Yang Liu , Rachel Sparks , Sebastien Ourselin , Christos Bergeles , Timothy Jackson

The well known domain shift issue causes model performance to degrade when deployed to a new target domain with different statistics to training. Domain adaptation techniques alleviate this, but need some instances from the target domain to…

Machine Learning · Computer Science 2019-06-11 Yiying Li , Yongxin Yang , Wei Zhou , Timothy M. Hospedales

Discrepancy between training and testing domains is a fundamental problem in the generalization of machine learning techniques. Recently, several approaches have been proposed to learn domain invariant feature representations through…

Machine Learning · Statistics 2019-03-18 Yitong Li , Michael Murias , Samantha Major , Geraldine Dawson , David E. Carlson

The process of digitising histology slides involves multiple factors that can affect a whole slide image's (WSI) final appearance, including the staining protocol, scanner, and tissue type. This variability constitutes a domain shift and…

Computer Vision and Pattern Recognition · Computer Science 2024-11-26 Manahil Raza , Saad Bashir , Talha Qaiser , Nasir Rajpoot

Domain adaptation is an active area of research driven by the growing demand for robust machine learning models that perform well on real-world data. Adversarial learning for deep neural networks (DNNs) has emerged as a promising approach…

Computer Vision and Pattern Recognition · Computer Science 2025-01-08 Eugene Choi , Julian Rodriguez , Edmund Young