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We study molecular dynamics within populations of diffusively coupled cells under the assumption of fast diffusive exchange. As a technical tool, we propose conditions on boundedness and ultimate boundedness for systems with a singular…

Cell Behavior · Quantitative Biology 2012-12-19 Steffen Waldherr , Frank Allgöwer

In this work we develop a microscopic physical model of early evolution, where phenotype,organism life expectancy, is directly related to genotype, the stability of its proteins in their native conformations which can be determined exactly…

Biomolecules · Quantitative Biology 2015-05-13 Konstantin Zeldovich , Peiqiu Chen , Boris Shakhnovich , Eugene Shakhnovich

Inspired by the need for effective stochastic models to describe the complex behavior of biological motor proteins that move on linear tracks exact results are derived for the velocity and dispersion of simple linear sequential models (or…

Statistical Mechanics · Physics 2009-10-31 Anatoly B. Kolomeisky , Michael E. Fisher

The purpose of the present effort is threefold. Firstly, it is shown that there exists a principle, that we call Kinetical Interaction Principle (KIP), underlying the non linear kinetics in particle systems, independently on the picture…

Statistical Mechanics · Physics 2009-11-07 G. Kaniadakis

The evolution of antimicrobial resistance generally occurs in an environment where antimicrobial concentration is variable, which has dramatic consequences on the microorganisms' fitness landscape, and thus on the evolution of resistance.…

Biological Physics · Physics 2018-10-23 Loïc Marrec , Anne-Florence Bitbol

Discrete time, spatially extended models play an important role in ecology, modelling population dynamics of species ranging from micro-organisms to birds. An important question is how 'bottom up', individual-based models can be…

Populations and Evolution · Quantitative Biology 2023-01-20 Linnéa Gyllingberg , David J. T. Sumpter , Åke Brännström

Within many bacterial colonies, persister cells exist as a subpopulation that is tolerant to antibiotics and other stressors, yet not genetically distinct from the rest of the colony. A recent study has proposed epigenetic inheritance as a…

Analysis of PDEs · Mathematics 2026-05-01 Chongming Li , Tyler Meadows , Troy Day

Understanding the organization of reaction fluxes in cellular metabolism from the stoichiometry and the topology of the underlying biochemical network is a central issue in systems biology. In this task, it is important to devise reasonable…

Molecular Networks · Quantitative Biology 2009-11-13 C. Martelli , A. De Martino , E. Marinari , M. Marsili , I. Perez Castillo

Cell crawling requires the generation of intracellular forces by the cytoskeleton and their transmission to an extracellular substrate through specific adhesion molecules. Crawling cells show many features of excitable systems, such as…

Biological Physics · Physics 2020-06-02 Pierre Sens

We use moving light patterns to control the motion of {\it Escherichia coli} bacteria whose motility is photo-activated. Varying the pattern speed controls the magnitude and direction of the bacterial flux, and therefore the accumulation of…

Investigations of natural variation among cells within a population are essential for understanding the stochastic nature of tissue cell deformation under applied load. In the existing literature, the population variation of single-cell…

Cell Behavior · Quantitative Biology 2011-07-14 John M. Maloney , Krystyn J. Van Vliet

The hindered diffusion model is introduced. It is a continuum model giving the dynamics of a conserved density. Similar to the spin-facilitated models, the kinetics are hindered by a fluctuating diffusion coefficient that decreases as the…

Statistical Mechanics · Physics 2007-05-23 Gene F Mazenko

If a localized quantum state in a tight-binding model with structural aperiodicity is subject to noisy evolution, then it is generally expected to result in diffusion and delocalization. In this work, it is shown that the localized phase of…

Statistical Mechanics · Physics 2021-04-20 Vikram Ravindranath , M. S. Santhanam

The Anderson localization phase transition in the Aubry-Andr\'e-Harper (AAH) model with \textit{p}-wave superconducting (SC) pairing is numerically investigated by suddenly changing the on-site potential from zero to various finite values…

Disordered Systems and Neural Networks · Physics 2018-06-04 Qi-Bo Zeng , Shu Chen , Rong Lü

In this paper we study a model of age-structured ecological populations in continuous interaction with a community of harvesters. We propose an individual-based model for this feedback interactions and prove its convergence to a system of…

A general theory is developed for the evolution of the cell order (CO) distribution in planar granular systems. Dynamic equations are constructed and solved in closed form for several examples: systems under compression; dilation of very…

Soft Condensed Matter · Physics 2019-09-27 Clara C. Wanjura , Paula Gago , Takashi Matsushima , Raphael Blumenfeld

We first discuss the geometrical construction and the main mathematical features of the maximum-entropy-production/steepest-entropy-ascent nonlinear evolution equation proposed long ago by this author in the framework of a fully quantum…

Quantum Physics · Physics 2015-05-13 Gian Paolo Beretta

We consider a non-conserving zero-range process with hopping rate proportional to the number of particles at each site. Particles are added to the system with a site-dependent creation rate, and removed from the system with a uniform…

Statistical Mechanics · Physics 2019-09-04 Pascal Grange

We present a constitutive model capturing some of the experimentally observed features of soft biological tissues: nonlinear viscoelasticity, nonlinear elastic anisotropy, and nonlinear viscous anisotropy. For this model we derive the…

Soft Condensed Matter · Physics 2007-12-04 Michel Destrade , Giuseppe Saccomandi

We propose a framework for constructing microscopic traffic models from microscopic acceleration patterns that can in principle be experimental measured and proper averaged. The exact model thus obtained can be used to justify the…

Adaptation and Self-Organizing Systems · Physics 2015-04-07 Bo Yang , Xihua Xu , John Z. F. Pang , Christopher Monterola
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