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Under the global health emergency caused by coronavirus disease 2019 (COVID-19), efficient and specific therapies are urgently needed. Compared with traditional small-molecular drugs, antibody therapies are relatively easy to develop and as…

Biomolecules · Quantitative Biology 2020-06-19 Jiahui Chen , Kaifu Gao , Rui Wang , Duc Duy Nguyen , Guo-Wei Wei

Statistical methods are developed for analysis of clinical and virus genetics data from phase 3 randomized, placebo-controlled trials of vaccines against novel coronavirus COVID-19. Vaccine efficacy (VE) of a vaccine to prevent COVID-19…

Methodology · Statistics 2022-01-25 Fei Heng , Yanqing Sun , Peter B. Gilbert

The phylogenetic tree of SARS-CoV-2 (nCov-19) viruses is reconstructed according to the similarity of genome sequences. The tree topology of Betacoronavirus is remarkably consistent with biologist's systematics. Because the tree…

Genomics · Quantitative Biology 2022-01-31 Yang Gao , Tao Li , Liaofu Luo

Diagnosis of COVID-19 is necessary to prevent and control the disease. Deep learning methods have been considered a fast and accurate method. In this paper, by the parallel combination of three well-known pre-trained networks, we attempted…

Image and Video Processing · Electrical Eng. & Systems 2022-08-17 Faezeh Amouzegar , Hamid Mirvaziri , Mostafa Ghazizadeh-Ahsaee , Mahdi Shariatzadeh

Recent advances in healthcare technologies have led to the availability of large amounts of biological samples across several techniques and applications. In particular, in the last few years, Raman spectroscopy analysis of biological…

Quantitative Methods · Quantitative Biology 2025-06-24 Marco Piazza , Andrea Spinelli , Francesca Maggioni , Marzia Bedoni , Enza Messina

The 2019 novel coronavirus (2019-nCoV) is currently causing a widespread outbreak centered on Hubei province, China and is a major public health concern. Taxonomically 2019-nCoV is closely related to SARS-CoV and SARS-related bat…

Biomolecules · Quantitative Biology 2020-02-18 Javier A. Jaimes , Nicole M. Andre , Jean K. Millet , Gary R. Whittaker

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the current global COVID-19 pandemic, in which millions of lives have been lost. Understanding the zoonotic evolution of the coronavirus may provide…

Populations and Evolution · Quantitative Biology 2022-01-04 Changchuan Yin

Machine learning and deep learning play vital roles in predicting diseases in the medical field. Machine learning algorithms are widely classified as supervised, unsupervised, and reinforcement learning. This paper contains a detailed…

Machine Learning · Computer Science 2023-01-27 D. Kamelesun , R. Saranya , P. Kathiravan

Machine learning (ML) models, such as SVM, for tasks like classification and clustering of sequences, require a definition of distance/similarity between pairs of sequences. Several methods have been proposed to compute the similarity…

Machine Learning · Computer Science 2022-09-13 Sarwan Ali , Bikram Sahoo , Muhammad Asad Khan , Alexander Zelikovsky , Imdad Ullah Khan , Murray Patterson

Antibody therapeutics and vaccines are among our last resort to end the raging COVID-19 pandemic. They, however, are prone to over 5,000 mutations on the spike (S) protein uncovered by a Mutation Tracker based on over 200,000 genome…

Biomolecules · Quantitative Biology 2021-03-10 Jiahui Chen , Kaifu Gao , Rui Wang , Guowei Wei

The outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) threatens global medical systems and economies, and rules our daily living life. Controlling the outbreak of SARS-CoV-2 has become one of the most important…

Medical Physics · Physics 2020-10-09 Jing Zhong , Enja Laureen Roesch , Thilo Viereck , Meinhard Schilling , Frank Ludwig

Coronaviruses have recently caused world-wide severe outbreaks: SARS (Severe Acute Respiratory Syndrome) in 2002 and MERS (Middle-East Respiratory Syndrome) in 2012. At the end of 2019, a new coronavirus outbreak appeared in Wuhan (China)…

Genomics · Quantitative Biology 2020-04-03 Miguel Ramos Pascual

Recent events leading to the worldwide pandemic of COVID-19 have demonstrated the effective use of genomic sequencing technologies to establish the genetic sequence of this virus. In contrast, the COVID-19 pandemic has demonstrated the…

Biomolecules · Quantitative Biology 2020-07-28 Niharika Pandala , Casey A. Cole , Devaun McFarland , Anita Nag , Homayoun Valafar

The severe acute respiratory syndrome coronavirus type-2 (SARS-CoV-2) caused a global pandemic and immensely affected the global economy. Accurate, cost-effective, and quick tests have proven substantial in identifying infected people and…

In this work, we aim to study that the dynamics behavior for cumulative number of SARS-CoV-2 pandemic can provide information on the overall behavior of the spread over daily time.The cumulative data can be synthesized in an empirical form…

Populations and Evolution · Quantitative Biology 2020-11-16 Hamieh Mohamad , Doumit Mary , Toufaily Joumana , Hamieh Tayssir

At the end of 2020, policy responses to the SARS-CoV-2 outbreak have been shaken by the emergence of virus variants. The emergence of these more contagious, more severe, or even vaccine-resistant strains have challenged worldwide policy…

Populations and Evolution · Quantitative Biology 2021-03-29 Aymeric Vie

The importance of the working document is that it allows the analysis of information and cases associated with (SARS-CoV-2) COVID-19, based on the daily information generated by the Government of Mexico through the Secretariat of Health,…

Computers and Society · Computer Science 2021-12-03 Medel-Ramírez Carlos , Medel-López Hilario , Lara-Mérida Jennifer

There are many sources of data giving information about the number of SARS-CoV-2 infections in the population, but all have major drawbacks, including biases and delayed reporting. For example, the number of confirmed cases largely…

Applications · Statistics 2022-06-08 Nicholas J. Irons , Adrian E. Raftery

The novel coronavirus variant, which is also widely known as COVID-19, is currently a common threat to all humans across the world. Effective recognition of COVID-19 using advanced machine learning methods is a timely need. Although many…

Image and Video Processing · Electrical Eng. & Systems 2022-08-02 Selvarajah Thuseethan , Chathrie Wimalasooriya , Shanmuganathan Vasanthapriyan

While many epidemiological models have being proposed to understand and handle COVID-19, too little has been invested to understand how the virus replicates in the human body and potential antiviral can be used to control the replication…