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The discovery of functional molecules is an expensive and time-consuming process, exemplified by the rising costs of small molecule therapeutic discovery. One class of techniques of growing interest for early-stage drug discovery is de novo…

Quantitative Methods · Quantitative Biology 2020-02-18 Wenhao Gao , Connor W. Coley

We introduce SynFormer, a generative modeling framework designed to efficiently explore and navigate synthesizable chemical space. Unlike traditional molecular generation approaches, we generate synthetic pathways for molecules to ensure…

Machine Learning · Computer Science 2024-10-07 Wenhao Gao , Shitong Luo , Connor W. Coley

Machine learning and especially deep learning has had an increasing impact on molecule and materials design. In particular, given the growing access to an abundance of high-quality small molecule data for generative modeling for drug…

Chemical Physics · Physics 2023-11-14 Shehtab Zaman , Denis Akhiyarov , Mauricio Araya-Polo , Kenneth Chiu

Advances in Generative AI tools have allowed designers to manipulate existing 3D models using text or image-based prompts, enabling creators to explore different design goals. Photochromic color-changing systems, on the other hand, allow…

Human-Computer Interaction · Computer Science 2024-04-29 Yunyi Zhu , Faraz Faruqi , Stefanie Mueller

Proteins are the fundamental macromolecules that play diverse and crucial roles in all living matter and have tremendous implications in healthcare, manufacturing, and biotechnology. Their functions are largely determined by the sequences…

Biomolecules · Quantitative Biology 2024-09-17 Boqiao Lai

In software development, the raw requirements proposed by users are frequently incomplete, which impedes the complete implementation of application functionalities. With the emergence of large language models, recent methods with the…

Software Engineering · Computer Science 2024-11-11 Sai Zhang , Zhenchang Xing , Ronghui Guo , Fangzhou Xu , Lei Chen , Zhaoyuan Zhang , Xiaowang Zhang , Zhiyong Feng , Zhiqiang Zhuang

New systems employ Machine Learning to sift through large knowledge sources, creating flexible Large Language Models. These models discern context and predict sequential information in various communication forms. Generative AI, leveraging…

Artificial Intelligence · Computer Science 2023-07-19 Ted Selker

Biomolecular interactions underpin almost all biological processes, and their rational design is central to programming new biological functions. Generative AI models have emerged as powerful tools for molecular design, yet most remain…

Molecular property prediction and generative design via deep learning models has been the subject of intense research given its potential to accelerate development of new, high-performance materials. More recently, these workflows have been…

Artificial Intelligence · Computer Science 2024-12-16 Nathaniel H. Park , Tiffany J. Callahan , James L. Hedrick , Tim Erdmann , Sara Capponi

The ability of Generative AI (GAI) technology to automatically check, synthesize and modify software engineering artifacts promises to revolutionize all aspects of software engineering. Using GAI for software engineering tasks is…

Software Engineering · Computer Science 2025-01-07 Marcus Kessel , Colin Atkinson

Recent generative AI advances present new possibilities for supporting visual art creation, but how such promise might assist novice artists during early-stage processes requires investigation. How novices adopt or resist these tools can…

Human-Computer Interaction · Computer Science 2025-10-01 Cindy Peng , Alice Qian , Linghao Jin , Jieneng Chen , Evans Xu Han , Paul Pu Liang , Hong Shen , Haiyi Zhu , Jane Hsieh

Generative Artificial Intelligence (Generative AI) is a collection of AI technologies that can generate new information such as texts and images. With its strong capabilities, Generative AI has been actively studied in creative design…

Human-Computer Interaction · Computer Science 2025-02-04 Liuging Chen , Yaxuan Song , Jia Guo , Lingyun Sun , Peter Childs , Yuan Yin

Generative models such as AlphaFold and MatterGen can directly generate novel material structures with desired properties, accelerating the new materials discovery and revolutionizing the material design paradigm from traditional…

Generative artificial intelligence (AI) has revolutionized the field of computational social science (CSS), unleashing new possibilities for collecting and analyzing multimodal data, especially for scholars who may not have extensive…

Human-Computer Interaction · Computer Science 2025-04-29 Yongjun Zhang

Searching new molecules in areas like drug discovery often starts from the core structures of candidate molecules to optimize the properties of interest. The way as such has called for a strategy of designing molecules retaining a…

Machine Learning · Computer Science 2020-09-03 Jaechang Lim , Sang-Yeon Hwang , Seungsu Kim , Seokhyun Moon , Woo Youn Kim

Generative AI brings novel and impressive abilities to help people in everyday tasks. There are many AI workflows that solve real and complex problems by chaining AI outputs together with human interaction. Although there is an undeniable…

Human-Computer Interaction · Computer Science 2024-06-03 Tao Long , Katy Ilonka Gero , Lydia B. Chilton

Despite the rapid evolution and increasing efficacy of language and vision generative models, there remains a lack of comprehensive datasets that bridge the gap between personalized fashion needs and AI-driven design, limiting the potential…

Computer Vision and Pattern Recognition · Computer Science 2024-09-16 Georgia Argyrou , Angeliki Dimitriou , Maria Lymperaiou , Giorgos Filandrianos , Giorgos Stamou

Deep learning has recently been applied to various research areas of design optimization. This study presents the need and effectiveness of adopting deep learning for generative design (or design exploration) research area. This work…

Machine Learning · Computer Science 2020-05-27 Sangeun Oh , Yongsu Jung , Seongsin Kim , Ikjin Lee , Namwoo Kang

Deep generative models have emerged as an exciting avenue for inverse molecular design, with progress coming from the interplay between training algorithms and molecular representations. One of the key challenges in their applicability to…

Generative Artificial Intelligence (AI), particularly tools like OpenAI's popular ChatGPT, is reshaping the landscape of computer science research. Used wisely, these tools can boost the productivity of a computer research scientist. This…

Artificial Intelligence · Computer Science 2023-11-21 Eduardo C. Garrido-Merchan