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Reconstructing the intricate local morphology of neurons and their long-range projecting axons can address many connectivity related questions in neuroscience. The main bottleneck in connectomics pipelines is correcting topological errors,…

Computer Vision and Pattern Recognition · Computer Science 2025-03-05 Anna Grim , Jayaram Chandrashekar , Uygar Sumbul

Whole heart segmentation (WHS) supports cardiovascular disease (CVD) diagnosis, disease monitoring, treatment planning, and prognosis. Deep learning has become the most widely used method for WHS applications in recent years. However,…

Image and Video Processing · Electrical Eng. & Systems 2024-10-21 Chenyu Zhang , Wenxue Guan , Xiaodan Xing , Guang Yang

Cardio-cerebrovascular diseases are the leading causes of mortality worldwide, whose accurate blood vessel segmentation is significant for both scientific research and clinical usage. However, segmenting cardio-cerebrovascular structures…

Image and Video Processing · Electrical Eng. & Systems 2024-04-03 Nazik Elsayed , Yousuf Babiker M. Osman , Cheng Li , Jiong Zhang , Shanshan Wang

Automatic segmentation of retinal blood vessels from fundus images plays an important role in the computer aided diagnosis of retinal diseases. The task of blood vessel segmentation is challenging due to the extreme variations in morphology…

Computer Vision and Pattern Recognition · Computer Science 2016-11-17 Avijit Dasgupta , Sonam Singh

Curvilinear structure segmentation is important in medical imaging, quantifying structures such as vessels, airways, neurons, or organ boundaries in 2D slices. Segmentation via pixel-wise classification often fails to capture the small and…

Image and Video Processing · Electrical Eng. & Systems 2023-03-07 Manxi Lin , Zahra Bashir , Martin Grønnebæk Tolsgaard , Anders Nymark Christensen , Aasa Feragen

With respect to spatial overlap, CNN-based segmentation of short axis cardiovascular magnetic resonance (CMR) images has achieved a level of performance consistent with inter observer variation. However, conventional training procedures…

Image and Video Processing · Electrical Eng. & Systems 2020-08-24 Nick Byrne , James R. Clough , Giovanni Montana , Andrew P. King

We present a novel method to explicitly incorporate topological prior knowledge into deep learning based segmentation, which is, to our knowledge, the first work to do so. Our method uses the concept of persistent homology, a tool from…

Computer Vision and Pattern Recognition · Computer Science 2019-01-30 James R. Clough , Ilkay Oksuz , Nicholas Byrne , Julia A. Schnabel , Andrew P. King

Automated blood vessel segmentation is vital for biomedical imaging, as vessel changes indicate many pathologies. Still, precise segmentation is difficult due to the complexity of vascular structures, anatomical variations across patients,…

In many biomedical segmentation tasks, the preservation of elongated structure continuity and length is more important than voxel-wise accuracy. We propose two novel loss functions, Negative Centerline Loss and Simplified Topology Loss,…

Computer Vision and Pattern Recognition · Computer Science 2025-09-04 Karol Szustakowski , Luk Frank , Julia Esser , Jan Gründemann , Marie Piraud

The vascular structure of blood vessels is important in diagnosing retinal conditions such as glaucoma and diabetic retinopathy. Accurate segmentation of these vessels can help in detecting retinal objects such as the optic disc and optic…

Image and Video Processing · Electrical Eng. & Systems 2020-12-18 Abdullah Sarhan , Jon Rokne , Reda Alhajj , Andrew Crichton

The morphology of retinal blood vessels can indicate various diseases in the human body, and researchers have been working on automatic scanning and segmentation of retinal images to aid diagnosis. This project compares the performance of…

Image and Video Processing · Electrical Eng. & Systems 2023-03-20 Ifeyinwa Linda Anene , Yongmin Li

We present a fully automatic, graph-based technique for extracting the retinal vascular topology -- that is, how different vessels are connected to each other -- given a single color fundus image. Determining this connectivity is very…

Image and Video Processing · Electrical Eng. & Systems 2022-08-09 Aashis Khanal , Saeid Motevali , Rolando Estrada

A novel topological segmentation of retinal images represents blood vessels as connected regions in the continuous image plane, having shape-related analytic and geometric properties. This paper presents topological segmentation results…

Computational Geometry · Computer Science 2016-08-05 Martin Brooks

The task of blood vessel segmentation in microscopy images is crucial for many diagnostic and research applications. However, vessels can look vastly different, depending on the transient imaging conditions, and collecting data for…

Image and Video Processing · Electrical Eng. & Systems 2019-08-19 Shir Gur , Lior Wolf , Lior Golgher , Pablo Blinder

Accurate vessel segmentation is crucial to assist in clinical diagnosis by medical experts. However, the intricate tree-like tubular structure of blood vessels poses significant challenges for existing segmentation algorithms. Small…

Image and Video Processing · Electrical Eng. & Systems 2025-07-08 Xiao Zhang , Zhuo Jin , Shaoxuan Wu , Fengyu Wang , Guansheng Peng , Xiang Zhang , Ying Huang , JingKun Chen , Jun Feng

Multi-class segmentation of cardiac magnetic resonance (CMR) images seeks a separation of data into anatomical components with known structure and configuration. The most popular CNN-based methods are optimised using pixel wise loss…

Image and Video Processing · Electrical Eng. & Systems 2022-09-09 Nick Byrne , James R Clough , Isra Valverde , Giovanni Montana , Andrew P King

Capturing the global topology of an image is essential for proposing an accurate segmentation of its domain. However, most of existing segmentation methods do not preserve the initial topology of the given input, which is detrimental for…

Computer Vision and Pattern Recognition · Computer Science 2022-08-19 Minh On Vu Ngoc , Yizi Chen , Nicolas Boutry , Jonathan Fabrizio , Clement Mallet

This paper proposes a novel topological learning framework that integrates networks of different sizes and topology through persistent homology. Such challenging task is made possible through the introduction of a computationally efficient…

Neurons and Cognition · Quantitative Biology 2023-01-30 Tananun Songdechakraiwut , Moo K. Chung

Estimating clinically-relevant vascular features following vessel segmentation is a standard pipeline for retinal vessel analysis, which provides potential ocular biomarkers for both ophthalmic disease and systemic disease. In this work, we…

Image and Video Processing · Electrical Eng. & Systems 2022-04-12 Yukun Zhou , Moucheng Xu , Yipeng Hu , Stefano B. Blumberg , An Zhao , Siegfried K. Wagner , Pearse A. Keane , Daniel C. Alexander

Measuring similarity between complex objects is a fundamental task in many scientific fields. When objects are represented as graphs, graph similarity/distance measures offer a powerful framework for quantifying structural resemblance.…

Combinatorics · Mathematics 2025-09-30 Matthias Dehmer , Izudin Redžepović , Niko Tratnik , Petra Žigert Pleteršek