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The Fast Dose Calculator (FDC), a track repeating algorithm Monte Carlo method was initially developed for proton therapy. The validation for proton therapy has been demonstrated in a previous work. This method can be expanded to ion…

Medical Physics · Physics 2018-09-18 Qianxia Wang , Antony Adair , Yu Deng , Hongliang Chen , M Moyers , James Lin , Pablo Yepes

Fast procedures for the beam quality assessment and for the monitoring of beam energy modulations during the irradiation are among the most urgent improvements in particle therapy. Indeed, the online measurement of the particle beam energy…

Positron emission tomography (PET) is a medical imaging method based on the measurement of concentrations of positron-emitting radionuclides in a living body. In the PET imaging system, glucose is labeled with a positron-emitting…

Signal Processing · Electrical Eng. & Systems 2022-09-27 Mehmet Akif Ozdemir , Ali Tangel

Novel radiotherapy techniques like synchrotron X-ray microbeam radiation therapy (MRT), require fast dose distribution predictions that are accurate at the sub-mm level, especially close to tissue/bone/air interfaces. Monte Carlo physics…

Purpose: Intensity-modulated proton therapy (IMPT) offers precise tumor coverage while sparing organs at risk (OARs) in head and neck (H&N) cancer. However, its sensitivity to anatomical changes requires frequent adaptation through online…

Computed Tomography (CT) measures the attenuation coefficient of an object and converts the value assigned to each voxel into a CT number. In radiation therapy, CT number, which is directly proportional to the linear attenuation…

Medical Physics · Physics 2015-03-13 Dong Joo Rhee , Sung-woo Kim , Young Min Moon , Jung Ki Kim , Dong Hyeok Jeong

We model the responses of Tissue-Equivalent Proportional Counters (TEPC) to radiation fields of therapeutic C-12 beams in a water phantom and to quasi-monoenergetic neutrons in a PMMA phantom. Simulations are performed with the Monte Carlo…

Medical Physics · Physics 2013-07-09 Lucas Burigo , Igor Pshenichnov , Igor Mishustin , Marcus Bleicher

Plastic scintillators detectors (PSDs) have been studied as dosimeters, since they provide a cost-effective alternative to conventional ionization chambers. Measurement and analysis of energy dependency were performed on a Siemens Mammomat…

Instrumentation and Detectors · Physics 2017-11-06 J. Antunes , J. Machado , L. Peralta , N. Matela

The distribution of produced isotopes during proton therapy can be imaged with Positron Emission Tomography (PET) to verify dose delivery. However, biological washout, driven by tissue-dependent processes such as perfusion and cellular…

Microdosimetry provides a superior characterization of the radiation field compared to conventional LET-based methodology, and for this reason it has become increasingly attractive for quality assurance in particle therapy. However, the…

Medical Physics · Physics 2025-04-08 E. Pierobon , M. Missiaggia , F. G. Cordoni , C. La Tessa

Recently, X-ray imaging dose from computed tomography (CT) or cone beam CT (CBCT) scans has become a serious concern. Patient-specific imaging dose calculation has been proposed for the purpose of dose management. While Monte Carlo (MC)…

Medical Physics · Physics 2015-05-30 Xun Jia , Hao Yan , Xuejun Gu , Steve B. Jiang

Purpose: To assess the effects of brain movements induced by heartbeat on dose distributions in synchrotron micro- and mini-beam radiaton therapy and to develop a model to help guide decisions and planning for future clinical trials.…

Medical Physics · Physics 2018-09-25 Francisco Manchado de Sola , Manuel Vilches , Yolanda Prezado , Antonio M. Lallena

PET requires accurate, precise, and efficient scatter correction techniques. Conventional scatter estimation typically relies on tail-fitted single-scatter simulation (SSS) strategy. However, the accuracy of tail-fitted SSS is limited, for…

Accurate proton dose calculation using Monte Carlo (MC) is computationally demanding in workflows like robust optimisation, adaptive replanning, and probabilistic inference, which require repeated evaluations. To address this, we develop a…

Machine Learning · Statistics 2025-09-24 Aaron Pim , Tristan Pryer

Online adaptive proton therapy (APT) is an ideal solution theoretically, which however is challenging to proton clinics. Although multiple groups have been endeavoring to develop online APT technology, there is a concern in the radiotherapy…

A new strategy for radiation therapy dosimetry planning (RTDP) used to reduce dose estimation errors due to respiratory motion in breast treatment was illustrated and evaluated in this study. On CT data set acquired for breast treatment,…

Medical Physics · Physics 2021-10-20 Mazen Moussallem , Pauline Harb , Hanane Rima , Zeina Al Kattar , Saad Ayoubi

Despite the fact that the first-order beam dynamics models allow an approximated evaluation of the beam properties, their contribution is essential during the conceptual design of an accelerator or beamline. However, during the…

Accelerator Physics · Physics 2017-12-20 V. Rizzoglio , A. Adelmann , C. Baumgarten , M. Frey , A. Gerbershagen , D. Meer , J. M. Schippers

Objective: Real-time adaptive proton range verification systems based on produced neutrons require accurate information on their non-isotropic momentum distributions within short times, for which Monte Carlo (MC) methods are too…

Purpose: The aim of this work was, a) to assess two treatment planning strategies for accounting CT-artifacts introduced by temporary tissue-expanders(TTEs); b) to evaluate the dosimetric impact of two commercially available and one novel…

Medical Physics · Physics 2023-05-08 Jose Ramos-Méndez , Catherine Park , Manju Sharma

Purpose: Retinoblastoma (RB) is the most common eye tumor in childhood and can be treated external radiotherapy. The purpose of this work is to evaluate the adequacy of Monte Carlo simulations and the accuracy of a commercial treatment…

Medical Physics · Physics 2018-09-26 L. Brualla , P. A. Mayorga , A. Flühs , A. M. Lallena , J. Sempau , W. Sauerwein