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Multiple imputation is a highly recommended technique to deal with missing data, but the application to longitudinal datasets can be done in multiple ways. When a new wave of longitudinal data arrives, we can treat the combined data of…

Methodology · Statistics 2026-05-18 X. M. Kavelaars , S. van Buuren , J. R. van Ginkel

Over the past years, Generative Adversarial Networks (GANs) have shown a remarkable generation performance especially in image synthesis. Unfortunately, they are also known for having an unstable training process and might loose parts of…

Machine Learning · Computer Science 2019-11-18 Teodora Pandeva , Matthias Schubert

There has been an increasing interest in using cell and gene therapy (CGT) to treat/cure difficult diseases. The hallmark of CGT trials are the small sample size and extremely high efficacy. Due to the innovation and novelty of such…

Applications · Statistics 2025-10-23 Yaoyuan Vincent Tan , Gang Xu , Chenkun Wang

Prevalent in biomedical applications (e.g., human phenotype research), multimodal datasets can provide valuable insights into the underlying physiological mechanisms. However, current machine learning (ML) models designed to analyze these…

Identifying genetic regulators of DNA methylation (mQTLs) with multivariate models enhances statistical power, but is challenged by missing data from bisulfite sequencing. Standard imputation-based methods can introduce bias, limiting…

Fusing data from multiple modalities provides more information to train machine learning systems. However, it is prohibitively expensive and time-consuming to label each modality with a large amount of data, which leads to a crucial problem…

Computer Vision and Pattern Recognition · Computer Science 2020-07-15 Xinwei Sun , Yilun Xu , Peng Cao , Yuqing Kong , Lingjing Hu , Shanghang Zhang , Yizhou Wang

Multimodal models often over-rely on dominant modalities, failing to achieve optimal performance. While prior work focuses on modifying training objectives or optimization procedures, data-centric solutions remain underexplored. We propose…

Machine Learning · Computer Science 2025-10-01 Seong-Hyeon Hwang , Soyoung Choi , Steven Euijong Whang

The masking-one-out (MOO) procedure, masking an observed entry and comparing it versus its imputed values, is a very common procedure for comparing imputation models. We study the optimum of this procedure and generalize it to a missing…

Methodology · Statistics 2025-11-14 Yanjiao Yang , Daniel Suen , Yen-Chi Chen

Missing data in online reinforcement learning (RL) poses challenges compared to missing data in standard tabular data or in offline policy learning. The need to impute and act at each time step means that imputation cannot be put off until…

Machine Learning · Statistics 2025-10-14 Kyla Chasalow , Skyler Wu , Susan Murphy

The problem of missing modalities is both critical and non-trivial to be handled in multi-modal models. It is common for multi-modal tasks that certain modalities contribute more compared to other modalities, and if those important…

Computer Vision and Pattern Recognition · Computer Science 2025-03-17 Hu Wang , Congbo Ma , Jianpeng Zhang , Yuan Zhang , Jodie Avery , Louise Hull , Gustavo Carneiro

This study introduces an innovative application of Conditional Generative Adversarial Networks (C-GAN) integrated with Stacked Hourglass Networks (SHGN) aimed at enhancing image segmentation, particularly in the challenging environment of…

Image and Video Processing · Electrical Eng. & Systems 2024-08-06 Haowei Yang , Yuxiang Hu , Shuyao He , Ting Xu , Jiajie Yuan , Xingxin Gu

Multimodal learning has increasingly become a focal point in research, primarily due to its ability to integrate complementary information from diverse modalities. Nevertheless, modality imbalance, stemming from factors such as insufficient…

Machine Learning · Computer Science 2025-11-04 Rongrong Xie , Guido Sanguinetti

Missing time-series data is a prevalent problem in many prescriptive analytics models in operations management, healthcare and finance. Imputation methods for time-series data are usually applied to the full panel data with the purpose of…

Methodology · Statistics 2023-04-13 Jose Blanchet , Fernando Hernandez , Viet Anh Nguyen , Markus Pelger , Xuhui Zhang

In many practical real-world applications, data missing is a very common phenomenon, making the development of data-driven artificial intelligence theory and technology increasingly difficult. Data completion is an important method for…

Machine Learning · Computer Science 2024-06-13 Xiaohua Pan , Weifeng Wu , Peiran Liu , Zhen Li , Peng Lu , Peijian Cao , Jianfeng Zhang , Xianfei Qiu , YangYang Wu

Background: Missing data is a common challenge in mass spectrometry-based metabolomics, which can lead to biased and incomplete analyses. The integration of whole-genome sequencing (WGS) data with metabolomics data has emerged as a…

Handling incomplete and heterogeneous data remains a central challenge in real-world machine learning, where missing values may follow complex mechanisms (MCAR, MAR, MNAR) and features can be of mixed types (numerical and categorical).…

Machine Learning · Computer Science 2025-07-30 Youran Zhou , Mohamed Reda Bouadjenek , Jonathan Wells , Sunil Aryal

Recently, we have witnessed impressive achievements in cancer survival analysis by integrating multimodal data, e.g., pathology images and genomic profiles. However, the heterogeneity and high dimensionality of these modalities pose…

Image and Video Processing · Electrical Eng. & Systems 2024-12-30 Huajun Zhou , Fengtao Zhou , Hao Chen

Numerous studies have shown that microbial metabolites, which represent the products of bacteria in the human gut, play a key role in shaping cancer risk and response to treatment. However, metabolite data typically contain a large…

Applications · Statistics 2026-05-19 Kai Jiang , Satabdi Saha , Christine B. Peterson

Missing data on response variables are common in clinical studies. Corresponding to the uncertainty of missing mechanism, theoretical frameworks on controlled imputation have been developed. In practice, it is recommended to conduct a…

Methodology · Statistics 2022-03-08 Tony Wang , Ying Liu

This paper focuses on the task of survival time analysis for lung cancer. Although much progress has been made in this problem in recent years, the performance of existing methods is still far from satisfactory. Traditional and some deep…

Computer Vision and Pattern Recognition · Computer Science 2022-11-08 Yujiao Wu , Yaxiong Wang , Xiaoshui Huang , Fan Yang , Sai Ho Ling , Steven Weidong Su