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Understanding and leveraging the 3D structures of proteins is central to a variety of biological and drug discovery tasks. While deep learning has been applied successfully for structure-based protein function prediction tasks, current…

Machine Learning · Computer Science 2024-04-03 Rong Han , Wenbing Huang , Lingxiao Luo , Xinyan Han , Jiaming Shen , Zhiqiang Zhang , Jun Zhou , Ting Chen

The task of drug-target interaction prediction holds significant importance in pharmacology and therapeutic drug design. In this paper, we present FRnet-DTI, an auto encoder and a convolutional classifier for feature manipulation and drug…

Machine Learning · Computer Science 2020-05-26 Farshid Rayhan , Sajid Ahmed , Zaynab Mousavian , Dewan Md Farid , Swakkhar Shatabda

Click-Through Rate (CTR) prediction, whose aim is to predict the probability of whether a user will click on an item, is an essential task for many online applications. Due to the nature of data sparsity and high dimensionality of CTR…

Information Retrieval · Computer Science 2021-08-18 Yichen Xu , Yanqiao Zhu , Feng Yu , Qiang Liu , Shu Wu

Semantic segmentation of remote sensing images plays an important role in a wide range of applications including land resource management, biosphere monitoring and urban planning. Although the accuracy of semantic segmentation in remote…

Image and Video Processing · Electrical Eng. & Systems 2021-09-21 Rui Li , Shunyi Zheng , Chenxi Duan , Ce Zhang , Jianlin Su , P. M. Atkinson

RNA structure prediction is a challenging problem, especially with pseudoknots. Recently, there has been a shift from the classical minimum free energy-based methods (MFE) to partition function-based ones that assemble structures using…

Biomolecules · Quantitative Biology 2020-01-10 Liang Zhang , He Zhang , David H. Mathews , Liang Huang

CRISPR-Cas13 is a system that utilizes single stranded RNAs for RNA editing. Prediction of on-target and off-target effects for the CRISPR-Cas13d dependency enables us to design specific single guide RNAs (sgRNAs) that help locate the…

Quantitative Methods · Quantitative Biology 2023-05-12 Jingze Liu , Jiahao Ma

Click-Through Rate (CTR) prediction is one of the most important and challenging in calculating advertisements and recommendation systems. To build a machine learning system with these data, it is important to properly model the interaction…

Machine Learning · Computer Science 2020-06-11 Dafang Zou , Leiming Zhang , Jiafa Mao , Weiguo Sheng

Metalearning of deep neural network (DNN) architectures and hyperparameters has become an increasingly important area of research. Loss functions are a type of metaknowledge that is crucial to effective training of DNNs, however, their…

Machine Learning · Computer Science 2020-10-05 Santiago Gonzalez , Risto Miikkulainen

Speech enhancement has benefited from the success of deep learning in terms of intelligibility and perceptual quality. Conventional time-frequency (TF) domain methods focus on predicting TF-masks or speech spectrum, via a naive convolution…

Audio and Speech Processing · Electrical Eng. & Systems 2020-09-24 Yanxin Hu , Yun Liu , Shubo Lv , Mengtao Xing , Shimin Zhang , Yihui Fu , Jian Wu , Bihong Zhang , Lei Xie

The subcellular localization of RNAs, including long non-coding RNAs (lncRNAs), messenger RNAs (mRNAs), microRNAs (miRNAs) and other smaller RNAs, plays a critical role in determining their biological functions. For instance, lncRNAs are…

Computer Vision and Pattern Recognition · Computer Science 2025-04-25 Cece Zhang , Xuehuan Zhu , Nick Peterson , Jieqiong Wang , Shibiao Wan

Microtubule networks (MTs) are a component of a cell that may indicate the presence of various chemical compounds and can be used to recognize properties such as treatment resistance. Therefore, the classification of MT images is of great…

Image and Video Processing · Electrical Eng. & Systems 2020-12-23 Aleksei Shpilman , Dmitry Boikiy , Marina Polyakova , Daniel Kudenko , Anton Burakov , Elena Nadezhdina

Food is not only essential to human health but also serves as a medium for cultural identity and emotional connection. In the context of precision nutrition, accurately identifying and classifying food images is critical for dietary…

Computer Vision and Pattern Recognition · Computer Science 2025-07-24 Lulu Liu , Zhiyong Xiao

Click-through rate (CTR) estimation plays as a core function module in various personalized online services, including online advertising, recommender systems, and web search etc. From 2015, the success of deep learning started to benefit…

Information Retrieval · Computer Science 2021-04-22 Weinan Zhang , Jiarui Qin , Wei Guo , Ruiming Tang , Xiuqiang He

The study of molecule-target interaction is quite important for drug discovery in terms of target identification, hit identification, pathway study, drug-drug interaction, etc. Most existing methodologies utilize either biomedical network…

Machine Learning · Computer Science 2023-02-07 Jinjiang Guo , Jie Li

Recently, microRNAs (miRNAs) have emerged as central posttranscriptional regulators of gene expression. miRNAs regulate many key biological processes, including cell growth, death, development and differentiation. This discovery is…

Molecular Networks · Quantitative Biology 2007-12-24 Edwin Wang

Click-through rate (CTR) prediction is an essential task in web applications such as online advertising and recommender systems, whose features are usually in multi-field form. The key of this task is to model feature interactions among…

Information Retrieval · Computer Science 2020-07-27 Zekun Li , Zeyu Cui , Shu Wu , Xiaoyu Zhang , Liang Wang

In the field of pattern recognition research, the method of using deep neural networks based on improved computing hardware recently attracted attention because of their superior accuracy compared to conventional methods. Deep neural…

Computer Vision and Pattern Recognition · Computer Science 2018-09-27 Kyongsik Yun , Alexander Huyen , Thomas Lu

Deep neural networks have recently achieved state of the art performance thanks to new training algorithms for rapid parameter estimation and new regularization methods to reduce overfitting. However, in practice the network architecture…

Machine Learning · Computer Science 2016-03-04 Minyoung Kim , Luca Rigazio

Deep learning (DL) has achieved remarkable progress in the field of medical imaging. However, adapting DL models to medical tasks remains a significant challenge, primarily due to two key factors: (1) architecture selection, as different…

Computer Vision and Pattern Recognition · Computer Science 2025-04-24 Lotfi Abdelkrim Mecharbat , Ibrahim Almakky , Martin Takac , Mohammad Yaqub

Fast and accurate predictions for complex physical dynamics are a significant challenge across various applications. Real-time prediction on resource-constrained hardware is even more crucial in real-world problems. The deep operator…

Machine Learning · Computer Science 2023-12-27 Jae Yong Lee , Sung Woong Cho , Hyung Ju Hwang