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In this paper, we propose a novel, effective and simpler end-to-end image clustering auto-encoder algorithm: ICAE. The algorithm uses PEDCC (Predefined Evenly-Distributed Class Centroids) as the clustering centers, which ensures the…

Computer Vision and Pattern Recognition · Computer Science 2021-08-24 Qiuyu Zhu , Zhengyong Wang

We present two deep generative models based on Variational Autoencoders to improve the accuracy of drug response prediction. Our models, Perturbation Variational Autoencoder and its semi-supervised extension, Drug Response Variational…

Machine Learning · Statistics 2017-07-07 Ladislav Rampasek , Daniel Hidru , Petr Smirnov , Benjamin Haibe-Kains , Anna Goldenberg

Sparse autoencoders (SAEs) have lately been used to uncover interpretable latent features in large language models. By projecting dense embeddings into a much higher-dimensional and sparse space, learned features become disentangled and…

Machine Learning · Computer Science 2025-07-30 Viktoria Schuster

This study introduces a compositional autoencoder (CAE) framework designed to disentangle the complex interplay between genotypic and environmental factors in high-dimensional phenotype data to improve trait prediction in plant breeding and…

Single-cell RNA sequencing (scRNA-seq) technology enables systematic delineation of cellular states and interactions, providing crucial insights into cellular heterogeneity. Building on this potential, numerous computational methods have…

Genomics · Quantitative Biology 2025-11-11 Ping Xu , Zaitian Wang , Zhirui Wang , Pengjiang Li , Ran Zhang , Gaoyang Li , Hanyu Xie , Jiajia Wang , Yuanchun Zhou , Pengfei Wang

An online resource scheduling framework is proposed for minimizing the sum of weighted task latency for all the Internet of things (IoT) users, by optimizing offloading decision, transmission power and resource allocation in the large-scale…

Machine Learning · Computer Science 2020-04-16 Feibo Jiang , Kezhi Wang , Li Dong , Cunhua Pan , Kun Yang

Single-cell RNA sequencing (scRNA-seq) reveals cell heterogeneity, with cell clustering playing a key role in identifying cell types and marker genes. Recent advances, especially graph neural networks (GNNs)-based methods, have…

Genomics · Quantitative Biology 2025-10-03 Ping Xu , Zhiyuan Ning , Pengjiang Li , Wenhao Liu , Pengyang Wang , Jiaxu Cui , Yuanchun Zhou , Pengfei Wang

Deep neural networks have long been criticized for being black-box. To unveil the inner workings of modern neural architectures, a recent work \cite{yu2024white} proposed an information-theoretic objective function called Sparse Rate…

Machine Learning · Computer Science 2024-11-27 Yunzhe Hu , Difan Zou , Dong Xu

Most deep latent factor models choose simple priors for simplicity, tractability or not knowing what prior to use. Recent studies show that the choice of the prior may have a profound effect on the expressiveness of the model,especially…

Machine Learning · Computer Science 2019-09-11 Hui-Po Wang , Wen-Hsiao Peng , Wei-Jan Ko

Learning compact and interpretable representations of data is a critical challenge in scientific image analysis. Here, we introduce Affinity-VAE, a generative model that enables us to impose our scientific intuition about the similarity of…

Stochastic regularization of neural networks (e.g. dropout) is a wide-spread technique in deep learning that allows for better generalization. Despite its success, continuous-time models, such as neural ordinary differential equation (ODE),…

Machine Learning · Computer Science 2020-06-29 Viktor Oganesyan , Alexandra Volokhova , Dmitry Vetrov

A common explanation for the failure of deep networks to generalize out-of-distribution is that they fail to recover the "correct" features. We challenge this notion with a simple experiment which suggests that ERM already learns sufficient…

Machine Learning · Computer Science 2022-10-31 Elan Rosenfeld , Pradeep Ravikumar , Andrej Risteski

Variational autoencoders (VAEs) are powerful tools for learning latent representations of data used in a wide range of applications. In practice, VAEs usually require multiple training rounds to choose the amount of information the latent…

Machine Learning · Computer Science 2023-08-21 Juhan Bae , Michael R. Zhang , Michael Ruan , Eric Wang , So Hasegawa , Jimmy Ba , Roger Grosse

A large part of the literature on learning disentangled representations focuses on variational autoencoders (VAE). Recent developments demonstrate that disentanglement cannot be obtained in a fully unsupervised setting without inductive…

Machine Learning · Computer Science 2021-02-11 Graziano Mita , Maurizio Filippone , Pietro Michiardi

Analyzing large-scale text corpora is a core challenge in machine learning, crucial for tasks like identifying undesirable model behaviors or biases in training data. Current methods often rely on costly LLM-based techniques (e.g.…

Artificial Intelligence · Computer Science 2025-12-12 Nick Jiang , Xiaoqing Sun , Lisa Dunlap , Lewis Smith , Neel Nanda

Combining neuroimaging datasets from multiple sites and scanners can help increase statistical power and thus provide greater insight into subtle neuroanatomical effects. However, site-specific effects pose a challenge by potentially…

Computer Vision and Pattern Recognition · Computer Science 2024-08-29 Ayodeji Ijishakin , Ana Lawry Aguila , Elizabeth Levitis , Ahmed Abdulaal , Andre Altmann , James Cole

Structured variational autoencoders (SVAEs) combine probabilistic graphical model priors on latent variables, deep neural networks to link latent variables to observed data, and structure-exploiting algorithms for approximate posterior…

Machine Learning · Statistics 2023-05-29 Yixiu Zhao , Scott W. Linderman

Single-cell RNA sequencing (scRNA-seq) is essential for unraveling cellular heterogeneity and diversity, offering invaluable insights for bioinformatics advancements. Despite its potential, traditional clustering methods in scRNA-seq data…

Machine Learning · Computer Science 2025-10-01 Ping Xu , Zhiyuan Ning , Meng Xiao , Guihai Feng , Xin Li , Yuanchun Zhou , Pengfei Wang

In variational autoencoders, the prior on the latent codes $z$ is often treated as an afterthought, but the prior shapes the kind of latent representation that the model learns. If the goal is to learn a representation that is interpretable…

Machine Learning · Computer Science 2018-10-17 Sharad Vikram , Matthew D. Hoffman , Matthew J. Johnson

We propose a novel deep clustering method that integrates Variational Autoencoders (VAEs) into the Expectation-Maximization (EM) framework. Our approach models the probability distribution of each cluster with a VAE and alternates between…

Machine Learning · Computer Science 2025-01-14 Michael Adipoetra , Ségolène Martin