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Pan-cancer classification using transcriptomic (RNA-Seq) data can inform tumor subtyping and therapy selection, but is challenging due to extremely high dimensionality and limited sample sizes. In this study, we propose a novel deep…

Genomics · Quantitative Biology 2025-08-06 Vinil Polepalli

Finding biologically plausible alternatives to back-propagation of errors is a fundamentally important challenge in artificial neural network research. In this paper, we propose a learning algorithm called error-driven Local Representation…

Neural and Evolutionary Computing · Computer Science 2018-11-19 Alexander G. Ororbia , Ankur Mali

Recurrent Neural Networks (RNN) received a vast amount of attention last decade. Recently, the architectures of Recurrent AutoEncoders (RAE) found many applications in practice. RAE can extract the semantically valuable information, called…

Machine Learning · Computer Science 2021-06-14 Robert Susik

Recent advancements in single-cell genomics necessitate precision in gene panel selection to interpret complex biological data effectively. Those methods aim to streamline the analysis of scRNA-seq data by focusing on the most informative…

Artificial Intelligence · Computer Science 2024-06-12 Weiliang Zhang , Zhen Meng , Dongjie Wang , Min Wu , Kunpeng Liu , Yuanchun Zhou , Meng Xiao

Latent generative models have emerged as a leading approach for high-quality image synthesis. These models rely on an autoencoder to compress images into a latent space, followed by a generative model to learn the latent distribution. We…

Machine Learning · Computer Science 2025-08-05 Theodoros Kouzelis , Ioannis Kakogeorgiou , Spyros Gidaris , Nikos Komodakis

The ability to accurately model random fields plays a critical role in science and engineering for problems involving uncertain, spatially-varying quantities such as heterogeneous material properties and turbulent flows. Deep generative…

Circular RNAs (circRNAs) are important components of the non-coding RNA regulatory network. Previous circRNA identification primarily relies on high-throughput RNA sequencing (RNA-seq) data combined with alignment-based algorithms that…

Machine Learning · Computer Science 2025-07-14 Tianyou Jiang

Variational autoencoders are prominent generative models for modeling discrete data. However, with flexible decoders, they tend to ignore the latent codes. In this paper, we study a VAE model with a deterministic decoder (DD-VAE) for…

Machine Learning · Computer Science 2020-03-05 Daniil Polykovskiy , Dmitry Vetrov

Inverse problems often involve matching observational data using a physical model that takes a large number of parameters as input. These problems tend to be under-constrained and require regularization to impose additional structure on the…

Computational Physics · Physics 2019-06-07 Daniel O'Malley , John K. Golden , Velimir V. Vesselinov

Single-cell RNA sequencing (scRNA-seq) has revolutionized our ability to analyze gene expression at the cellular level. By providing data on gene expression for each individual cell, scRNA-seq generates large datasets with thousands of…

Computational Complexity · Computer Science 2025-02-11 Md Romizul Islam , Swakkhar Shatabda

Our understanding of learning input-output relationships with neural nets has improved rapidly in recent years, but little is known about the convergence of the underlying representations, even in the simple case of linear autoencoders…

Machine Learning · Computer Science 2021-10-04 Xuchan Bao , James Lucas , Sushant Sachdeva , Roger Grosse

In recent years Variation Autoencoders have become one of the most popular unsupervised learning of complicated distributions.Variational Autoencoder (VAE) provides more efficient reconstructive performance over a traditional autoencoder.…

Machine Learning · Statistics 2017-07-12 Gautam Ramachandra

Microarrays are made it possible to simultaneously monitor the expression profiles of thousands of genes under various experimental conditions. Identification of co-expressed genes and coherent patterns is the central goal in microarray or…

Computational Engineering, Finance, and Science · Computer Science 2013-07-15 T. Chandrasekhar , K. Thangavel , E. Elayaraja , E. N. Sathishkumar

Representation Autoencoders (RAE) replace traditional VAE with pretrained vision encoders. In this paper, we systematically investigate several design choices and find three insights which simplify and improve RAE. First, we study a…

Computer Vision and Pattern Recognition · Computer Science 2026-05-19 Jaskirat Singh , Boyang Zheng , Zongze Wu , Richard Zhang , Eli Shechtman , Saining Xie

Variational Autoencoder (VAE)-based generative models offer flexible representation learning by incorporating meta-priors, general premises considered beneficial for downstream tasks. However, the incorporated meta-priors often involve…

Machine Learning · Computer Science 2023-02-27 Nao Nakagawa , Ren Togo , Takahiro Ogawa , Miki Haseyama

Objective: This paper investigates how generative models, trained on ground-truth images, can be used \changes{as} priors for inverse problems, penalizing reconstructions far from images the generator can produce. The aim is that learned…

Image and Video Processing · Electrical Eng. & Systems 2023-08-07 Margaret Duff , Ivor J. A. Simpson , Matthias J. Ehrhardt , Neill D. F. Campbell

Anomaly detection in tabular data remains challenging due to complex feature interactions and the scarcity of anomalous examples. Denoising autoencoders rely on fixed-magnitude noise, limiting adaptability to diverse data distributions.…

Machine Learning · Computer Science 2025-08-04 Timur Sattarov , Marco Schreyer , Damian Borth

Identifying customer segments in retail banking portfolios with different risk profiles can improve the accuracy of credit scoring. The Variational Autoencoder (VAE) has shown promising results in different research domains, and it has been…

Computational Engineering, Finance, and Science · Computer Science 2018-06-08 Rogelio Andrade Mancisidor , Michael Kampffmeyer , Kjersti Aas , Robert Jenssen

State-of-the-art Variational Auto-Encoders (VAEs) for learning disentangled latent representations give impressive results in discovering features like pitch, pause duration, and accent in speech data, leading to highly controllable…

Sound · Computer Science 2021-05-11 Shakti Kumar , Jithin Pradeep , Hussain Zaidi

Variational autoencoders (VAEs) frequently suffer from posterior collapse, where the latent variables become uninformative as the approximate posterior degenerates to the prior. While recent work has characterized collapse as a phase…

Machine Learning · Computer Science 2026-05-19 Zegu Zhang , Jian Zhang
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