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Models in systems biology are mathematical descriptions of biological processes that are used to answer questions and gain a better understanding of biological phenomena. Dynamic models represent the network through rates of the production…
The phage $\lambda$ infection of an \textit{E. coli} cell has become a paradigm for understanding the molecular processes involved in gene expression and cell signaling. This system provides an example of a genetic switch, as cells with…
In building practical applications of evolutionary computation (EC), two optimizations are essential. First, the parameters of the search method need to be tuned to the domain in order to balance exploration and exploitation effectively.…
Star cluster formation is a major mode of star formation in the extreme conditions of interacting galaxies and violent starbursts. Young clusters are observed to form in a variety of such galaxies, a substantial number resembling the…
We employ the framework of multitype Galton-Watson processes to model a population of dividing cells. The cellular type is represented by its biological age, defined as the count of harmful proteins hosted by the cell. The stochastic…
We investigate the evolution of Boolean networks subject to a selective pressure which favors robustness against noise, as a model of evolved genetic regulatory systems. By mapping the evolutionary process into a statistical ensemble and…
Identifying past wet merger activity in galaxies has been a longstanding issue in extragalactic formation history studies. Gaia's 6D kinematic measurements in our Milky Way (MW) have vastly extended the possibilities for Galactic…
Status quo and perspectives of standard chemical evolution models of Local Group galaxies are summarized, discussing what we have learnt from them, what we know we have not learnt yet, and what I think we will learn in the near future. It…
The formation, growth and detachment of gas bubbles on electrodes are omnipresent in electrolysis and other gas-producing chemical processes. To better understand their role in the mass transfer efficiency, we perform experiments involving…
Recent experiments have illuminated a remarkable growth mechanism of rod-shaped bacteria: proteins associated with cell wall extension move at constant velocity in circles oriented approximately along the cell circumference (Garner et al.,…
In bacteria, regulatory proteins search for a specific DNA binding target via "facilitated diffusion": a series of rounds of 3D diffusion in the cytoplasm, and 1D linear diffusion along the DNA contour. Using large scale Brownian dynamics…
Effective biological utilization of wood biomass is necessary worldwide. Since several insect larvae can use wood biomass as a nutrient source, studies on their digestive mechanism are expected to speculate a novel rule in wood biomass…
Coexpression of genes or, more generally, similarity in the expression profiles poses an unsurmountable obstacle to inferring the gene regulatory network (GRN) based solely on data from DNA microarray time series. Clustering of genes with…
Galaxies evolve under the influence of gas flows between their interstellar medium and their surrounding gaseous halos known as the circumgalactic medium (CGM). The CGM is a major reservoir of galactic baryons and metals, and plays a key…
Galaxy disks evolve through angular momentum transfers between sub-components, like gas, stars, or dark matter halos, through non axi-symmetric instabilities. The speed of this evolution is boosted in presence of a large fraction of cold…
Galaxies with Milky Way-like stellar masses have a wide range of bulge and black hole masses; in turn, these correlate with other properties such as star formation history. While many processes may drive bulge formation, major and minor…
Communication and coordination play a major role in the ability of bacterial cells to adapt to ever changing environments and conditions. Recent work has shown that such coordination underlies several aspects of bacterial responses…
Knowledge of ages for stars formed over a galaxy's lifetime is fundamental to understand its formation and evolution. However, stellar ages are difficult to obtain since they cannot be measured from observations, being comparison with…
Since chemical abundances are inherited between generations of stars, we use them to trace the evolutionary history of our Galaxy. We present a robust methodology for creating a phylogenetic tree, a biological tool used for centuries to…
Cholecystectomy is one of the most frequently performed procedures in gastrointestinal surgery, and the laparoscopic approach is the gold standard for symptomatic cholecystolithiasis and acute cholecystitis. In addition to the advantages of…