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Motivation: 3D neuron segmentation is a key step for the neuron digital reconstruction, which is essential for exploring brain circuits and understanding brain functions. However, the fine line-shaped nerve fibers of neuron could spread in…

Image and Video Processing · Electrical Eng. & Systems 2021-11-09 Qiufu Li , Linlin Shen

Automatic 3D neuron reconstruction is critical for analysing the morphology and functionality of neurons in brain circuit activities. However, the performance of existing tracing algorithms is hinged by the low image quality. Recently, a…

Image and Video Processing · Electrical Eng. & Systems 2021-09-17 Heng Wang , Chaoyi Zhang , Jianhui Yu , Yang Song , Siqi Liu , Wojciech Chrzanowski , Weidong Cai

Segmentation of cell nuclei in microscopy images is a prevalent necessity in cell biology. Especially for three-dimensional datasets, manual segmentation is prohibitively time-consuming, motivating the need for automated methods.…

Computer Vision and Pattern Recognition · Computer Science 2020-02-10 Peter Hirsch , Dagmar Kainmueller

Volumetric image segmentation with convolutional neural networks (CNNs) encounters several challenges, which are specific to medical images. Among these challenges are large volumes of interest, high class imbalances, and difficulties in…

Computer Vision and Pattern Recognition · Computer Science 2019-11-12 Fabian Balsiger , Yannick Soom , Olivier Scheidegger , Mauricio Reyes

Segmentation in 3D scans is playing an increasingly important role in current clinical practice supporting diagnosis, tissue quantification, or treatment planning. The current 3D approaches based on convolutional neural networks usually…

Computer Vision and Pattern Recognition · Computer Science 2019-03-12 Alexey Novikov , David Major , Maria Wimmer , Dimitrios Lenis , Katja Bühler

Unprecedented visual details of biological structures are being revealed by subcellular-resolution whole-brain 3D microscopy data, enabled by recent advances in intact tissue processing and light-sheet fluorescence microscopy (LSFM). These…

Computer Vision and Pattern Recognition · Computer Science 2026-04-01 Minyoung E. Kim , Dae Hee Yun , Aditi V. Patel , Madeline Hon , Webster Guan , Taegeon Lee , Brian Nguyen

Automated sample preparation and electron microscopy enables acquisition of very large image data sets. These technical advances are of special importance to the field of neuroanatomy, as 3D reconstructions of neuronal processes at the nm…

This paper investigates the application of deep convolutional neural networks with prohibitively small datasets to the problem of macular edema segmentation. In particular, we investigate several different heavily regularized architectures.…

Image and Video Processing · Electrical Eng. & Systems 2020-05-12 Jonathan Frawley , Chris G. Willcocks , Maged Habib , Caspar Geenen , David H. Steel , Boguslaw Obara

In recent years, 3D convolutional neural networks have become the dominant approach for volumetric medical image segmentation. However, compared to their 2D counterparts, 3D networks introduce substantially more training parameters and…

Image and Video Processing · Electrical Eng. & Systems 2022-06-01 Yuan Wang , Laura Blackie , Irene Miguel-Aliaga , Wenjia Bai

Accurate segmentation of 3-D cell nuclei in microscopy images is essential for the study of nuclear organization, gene expression, and cell morphodynamics. Current image segmentation methods are challenged by the complexity and variability…

Image and Video Processing · Electrical Eng. & Systems 2022-03-18 Sundaresh Ram , Jeffrey J. Rodriguez

Accurate detection and segmentation of brain tumors in magnetic resonance imaging (MRI) are critical for effective diagnosis and treatment planning. Despite advances in convolutional neural networks (CNNs) such as U-Net, existing models…

Computer Vision and Pattern Recognition · Computer Science 2025-10-14 Sashank Makanaboyina

Cell nuclei segmentation is one of the most important tasks in the analysis of biomedical images. With ever-growing sizes and amounts of three-dimensional images to be processed, there is a need for better and faster segmentation methods.…

Computer Vision and Pattern Recognition · Computer Science 2017-02-20 Julian Arz , Peter Sanders , Johannes Stegmaier , Ralf Mikut

Quantitative microstructural characterization is fundamental to materials science, where electron micrograph (EM) provides indispensable high-resolution insights. However, progress in deep learning-based EM characterization has been…

Computer Vision and Pattern Recognition · Computer Science 2025-08-25 Nan wang , Zhiyi Xia , Yiming Li , Shi Tang , Zuxin Fan , Xi Fang , Haoyi Tao , Xiaochen Cai , Guolin Ke , Linfeng Zhang , Yanhui Hong

Accurate brain tissue segmentation in Magnetic Resonance Imaging (MRI) has attracted the attention of medical doctors and researchers since variations in tissue volume help in diagnosing and monitoring neurological diseases. Several…

Computer Vision and Pattern Recognition · Computer Science 2019-07-30 Jose Bernal , Kaisar Kushibar , Mariano Cabezas , Sergi Valverde , Arnau Oliver , Xavier Lladó

Medical image segmentation has been so far achieving promising results with Convolutional Neural Networks (CNNs). However, it is arguable that in traditional CNNs, its pooling layer tends to discard important information such as positions.…

Image and Video Processing · Electrical Eng. & Systems 2022-04-12 Tan Nguyen , Binh-Son Hua , Ngan Le

Advances in fluorescence microscopy enable acquisition of 3D image volumes with better image quality and deeper penetration into tissue. Segmentation is a required step to characterize and analyze biological structures in the images and…

Computer Vision and Pattern Recognition · Computer Science 2019-04-16 Chichen Fu , Soonam Lee , David Joon Ho , Shuo Han , Paul Salama , Kenneth W. Dunn , Edward J. Delp

Accurate volume segmentation from the Computed Tomography (CT) scan is a common prerequisite for pre-operative planning, intra-operative guidance and quantitative assessment of therapeutic outcomes in robot-assisted Minimally Invasive…

Image and Video Processing · Electrical Eng. & Systems 2020-03-10 Peichao Li , Xiao-Yun Zhou , Zhao-Yang Wang , Guang-Zhong Yang

Deep cerebellar nuclei are a key structure of the cerebellum that are involved in processing motor and sensory information. It is thus a crucial step to accurately segment deep cerebellar nuclei for the understanding of the cerebellum…

Image and Video Processing · Electrical Eng. & Systems 2020-06-02 Jinyoung Kim , Remi Patriat , Jordan Kaplan , Oren Solomon , Noam Harel

Electron microscopy (EM) enables the reconstruction of neural circuits at the level of individual synapses, which has been transformative for scientific discoveries. However, due to the complex morphology, an accurate reconstruction of…

Object segmentation is an important step in the workflow of computational pathology. Deep learning based models generally require large amount of labeled data for precise and reliable prediction. However, collecting labeled data is…

Computer Vision and Pattern Recognition · Computer Science 2020-07-08 Navid Alemi Koohbanani , Mostafa Jahanifar , Neda Zamani Tajadin , Nasir Rajpoot