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Cluster randomized trials (CRTs) frequently recruit a small number of clusters, therefore necessitating the application of small-sample corrections for valid inference. A recent systematic review indicated that CRTs reporting…

Methodology · Statistics 2022-09-07 Xueqi Wang , Elizabeth L. Turner , Fan Li

Regression tree (RT) has been widely used in machine learning and data mining community. Given a target data for prediction, a regression tree is first constructed based on a training dataset before making prediction for each leaf node. In…

Machine Learning · Computer Science 2020-10-22 Xingchun Xiang , Qingtao Tang , Huaixuan Zhang , Tao Dai , Jiawei Li , Shu-Tao Xia

This report outlines work by the Modeling Transformative AI Risk (MTAIR) project, an attempt to map out the key hypotheses, uncertainties, and disagreements in debates about catastrophic risks from advanced AI, and the relationships between…

Artificial Intelligence · Computer Science 2022-06-22 Sam Clarke , Ben Cottier , Aryeh Englander , Daniel Eth , David Manheim , Samuel Dylan Martin , Issa Rice

Despite their cost, randomized controlled trials (RCTs) are widely regarded as gold-standard evidence in disciplines ranging from social science to medicine. In recent decades, researchers have increasingly sought to reduce the resource…

Methodology · Statistics 2026-02-24 Guilherme Duarte

Restricted mean survival time (RMST) offers a compelling nonparametric alternative to hazard ratios for right-censored time-to-event data, particularly when the proportional hazards assumption is violated. By capturing the total event-free…

Methodology · Statistics 2025-01-28 Jinghao Sun , Douglas E. Schaubel , Eric J. Tchetgen Tchetgen

Micro-randomized trials are commonly conducted for optimizing mobile health interventions such as push notifications for behavior change. In analyzing such trials, causal excursion effects are often of primary interest, and their estimation…

Methodology · Statistics 2024-08-19 Yihan Bao , Lauren Bell , Elizabeth Williamson , Claire Garnett , Tianchen Qian

The restricted mean survival time (RMST) is the mean survival time in the study population followed up to a specific time point, and is simply the area under the survival curve up to the specific time point. The difference between two RMSTs…

Methodology · Statistics 2025-09-18 Peter Zhang , Brent Logan , Michael Martens

Cluster randomized trials (CRTs) are studies where treatment is randomized at the cluster level but outcomes are typically collected at the individual level. When CRTs are employed in pragmatic settings, baseline population characteristics…

Methodology · Statistics 2023-06-22 Mary M. Ryan , Denise Esserman , Fan Li

Many epidemiological questions concern potential interventions to alter the pathways presumed to mediate an association. For example, we consider a study that investigates the benefit of interventions in young adulthood for ameliorating the…

Methodology · Statistics 2020-07-14 Margarita Moreno-Betancur , Paul Moran , Denise Becker , George C Patton , John B Carlin

AI models are often evaluated based on their ability to predict the outcome of interest. However, in many AI for social impact applications, the presence of an intervention that affects the outcome can bias the evaluation. Randomized…

Machine Learning · Computer Science 2025-11-18 Winston Chen , Michael W. Sjoding , Jenna Wiens

Randomized controlled trials (RCTs) often include subgroup analyses to assess whether treatment effects vary across pre-specified patient populations. However, these analyses frequently suffer from small sample sizes which limit the power…

Evidence syntheses and meta-analyses are used to inform clinical practice guidelines and health economic evaluations. However, heterogeneity of treatment effects poses a significant challenge. Conventional meta-analysis addresses…

User studies are crucial for meeting user needs. In user studies, real experimental scenarios and participants are constructed and recruited. However, emerging and unfamiliar studies face limitations, including safety concerns and iterative…

Human-Computer Interaction · Computer Science 2025-05-08 Shengdi Xiao , Jingjing Li , Tatsuki Fushimi , Yoichi Ochiai

There is a growing literature on design-based methods to estimate average treatment effects (ATEs) for randomized controlled trials (RCTs) for full sample analyses. This article extends these methods to estimate ATEs for discrete subgroups…

Methodology · Statistics 2023-10-16 Peter Z. Schochet

Recent progress in randomized motion planners has led to the development of a new class of sampling-based algorithms that provide asymptotic optimality guarantees, notably the RRT* and the PRM* algorithms. Careful analysis reveals that the…

Robotics · Computer Science 2016-09-21 Oktay Arslan , Panagiotis Tsiotras

The Model Parameter Randomisation Test (MPRT) is widely acknowledged in the eXplainable Artificial Intelligence (XAI) community for its well-motivated evaluative principle: that the explanation function should be sensitive to changes in the…

Artificial Intelligence · Computer Science 2024-01-15 Anna Hedström , Leander Weber , Sebastian Lapuschkin , Marina MC Höhne

A framework for online robust adaptive radiation therapy (ART) is presented. This framework is designed to (i) handle interfractional geometric variations following a probability distribution different from the a priori hypothesis, (ii)…

Medical Physics · Physics 2020-09-09 Michelle Böck

Dynamic treatment regimens (DTRs), also known as treatment algorithms or adaptive interventions, play an increasingly important role in many health domains. DTRs are motivated to address the unique and changing needs of individuals by…

Micro-expression recognition (MER) is crucial in the affective computing field due to its wide application in medical diagnosis, lie detection, and criminal investigation. Despite its significance, obtaining micro-expression (ME)…

Computer Vision and Pattern Recognition · Computer Science 2025-08-14 Jiateng Liu , Hengcan Shi , Feng Chen , Zhiwen Shao , Yaonan Wang , Jianfei Cai , Wenming Zheng

Response-adaptive randomisation (RAR) can considerably improve the chances of a successful treatment outcome for patients in a clinical trial by skewing the allocation probability towards better performing treatments as data accumulates.…

Applications · Statistics 2017-03-14 Sofia S. Villar , Jack Bowden , James Wason