Related papers: A projection-domain low-count quantitative SPECT m…
With the development of computed tomography (CT) imaging technology, it is possible to acquire multi-energy data by spectral CT. Being different from conventional CT, the X-ray energy spectrum of spectral CT is cutting into several narrow…
Miniaturized spectrometers employing chip solutions are essential for a wide range of applications, such as wearable health monitoring, biochemical sensing, and portable optical coherence tomography. However, the development of integrated…
In this thesis, we discuss the design and calibration (geometric and radiometric) of a novel shape and reflectance acquisition device called the "Multispectral Light Stage". This device can capture highly detailed facial geometry (down to…
Dual-energy computed tomography (DECT) is a promising technology that has shown a number of clinical advantages over conventional X-ray CT, such as improved material identification, artifact suppression, etc. For proton therapy treatment…
To obtain high-quality positron emission tomography (PET) while minimizing radiation exposure, a range of methods have been designed to reconstruct standard-dose PET (SPET) from corresponding low-dose PET (LPET) images. However, most…
Single-Photon Emission Computed Tomography (SPECT) is widely applied for the diagnosis of coronary artery diseases. Low-dose (LD) SPECT aims to minimize radiation exposure but leads to increased image noise. Limited-view (LV) SPECT, such as…
Attenuation compensation (AC) is a pre-requisite for reliable quantification and beneficial for visual interpretation tasks in single-photon emission computed tomography (SPECT). Typical AC methods require the availability of an attenuation…
Photoacoustic computed tomography (PACT) is an emerging computed imaging modality that exploits optical contrast and ultrasonic detection principles to form images of the absorbed optical energy density within tissue. When the imaging…
Receptor occupancy (RO) studies using PET neuroimaging play a critical role in the development of drugs targeting the central nervous system (CNS). The conventional approach to estimate drug receptor occupancy consists in estimation of…
Spectral computed tomography has received considerable interest in recent years since spectral measurements contain much richer information about the object of interest. In spectral computed tomography, we are interested in the energy…
Computed Tomography (CT) is an essential non-destructive three dimensional imaging modality used in medicine, security screening, and inspection of manufactured components. Typical CT data acquisition entails the collection of a thousand or…
Quantitative molecular imaging is central to treatment response assessment in oncology, yet clinical practice remains largely dominated by patient-level or limited target-lesion criteria that ignore inter-lesion heterogeneity. This…
Objective: Quantitative technique based on In-line phase-contrast computed tomography with single scanning attracts more attention in application due to the flexibility of the implementation. However, the quantitative results usually suffer…
In this paper, we describe the numerical reconstruction method for quantitative photoacoustic tomography (QPAT) based on the radiative transfer equation (RTE), which models light propagation more accurately than diffusion approximation…
For dose calculations in ion beam therapy, it is vital to accurately determine the relative stopping power (RSP) distribution within the treated volume. Currently, RSP values are extrapolated from Hounsfield units (HU), measured with x-ray…
Surgical tumor resection aims to remove all cancer cells in the tumor margin and at centimeter-scale depths below the tissue surface. During surgery, microscopic clusters of disease are intraoperatively difficult to visualize and are often…
Purpose: Many useful image quality metrics for evaluating linear image reconstruction techniques do not apply to or are difficult to interpret for non-linear image reconstruction. The vast majority of metrics employed for evaluating…
Spectro-microscopy is an experimental technique which can be used to observe spatial variations in chemical state and changes in chemical state over time or under experimental conditions. As a result it has broad applications across areas…
Spectral photon-counting X-ray CT (sCT) opens up new possibilities for the quantitative measurement of materials in an object, compared to conventional energy-integrating CT or dual energy CT. However, achieving reliable and accurate…
Purpose: To develop a motion-robust and geometrically-accurate quantitative CEST approach using radial k-space sampling, locally low-rank reconstruction and neural network quantification. Methods: The acquisition schedule was generated via…