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This paper presents a comprehensive systematic review of generative models (GANs, VAEs, DMs, and LLMs) used to synthesize various medical data types, including imaging (dermoscopic, mammographic, ultrasound, CT, MRI, and X-ray), text,…

Large-scale clinical data is invaluable to driving many computational scientific advances today. However, understandable concerns regarding patient privacy hinder the open dissemination of such data and give rise to suboptimal siloed…

Computation and Language · Computer Science 2019-05-23 Oren Melamud , Chaitanya Shivade

Individual health data is crucial for scientific advancements, particularly in developing Artificial Intelligence (AI); however, sharing real patient information is often restricted due to privacy concerns. A promising solution to this…

Recent years have witnessed a growing academic and industrial interest in deep learning (DL) for medical imaging. To perform well, DL models require very large labeled datasets. However, most medical imaging datasets are small, with a…

Computer Vision and Pattern Recognition · Computer Science 2025-03-04 Minh H. Vu , Lorenzo Tronchin , Tufve Nyholm , Tommy Löfstedt

Clinical data usually cannot be freely distributed due to their highly confidential nature and this hampers the development of machine learning in the healthcare domain. One way to mitigate this problem is by generating realistic synthetic…

Deep learning algorithms require extensive data to achieve robust performance. However, data availability is often restricted in the medical domain due to patient privacy concerns. Synthetic data presents a possible solution to these…

Sonography synthesis has a wide range of applications, including medical procedure simulation, clinical training and multimodality image registration. In this paper, we propose a machine learning approach to simulate ultrasound images at…

Machine Learning · Computer Science 2017-09-19 Yipeng Hu , Eli Gibson , Li-Lin Lee , Weidi Xie , Dean C. Barratt , Tom Vercauteren , J. Alison Noble

Smartwatch health sensor data are increasingly utilized in smart health applications and patient monitoring, including stress detection. However, such medical data often comprise sensitive personal information and are resource-intensive to…

Machine Learning · Computer Science 2026-02-03 Lucas Lange , Nils Wenzlitschke , Erhard Rahm

AI requires extensive datasets, while medical data is subject to high data protection. Anonymization is essential, but poses a challenge for some regions, such as the head, as identifying structures overlap with regions of clinical…

The widespread use of big data across sectors has raised major privacy concerns, especially when sensitive information is shared or analyzed. Regulations such as GDPR and HIPAA impose strict controls on data handling, making it difficult to…

Machine Learning · Computer Science 2025-12-10 Anantaa Kotal , Anupam Joshi

The widespread adoption of electronic health records and digital healthcare data has created a demand for data-driven insights to enhance patient outcomes, diagnostics, and treatments. However, using real patient data presents privacy and…

Machine Learning · Computer Science 2023-11-15 Aryan Jadon , Shashank Kumar

Medical image processing has been highlighted as an area where deep learning-based models have the greatest potential. However, in the medical field in particular, problems of data availability and privacy are hampering research progress…

Image and Video Processing · Electrical Eng. & Systems 2023-10-27 Christoph Angermann , Johannes Bereiter-Payr , Kerstin Stock , Markus Haltmeier , Gerald Degenhart

Compared to traditional methods, Deep Learning (DL) becomes a key technology for computer vision tasks. Synthetic data generation is an interesting use case for DL, especially in the field of medical imaging such as Magnetic Resonance…

Computer Vision and Pattern Recognition · Computer Science 2025-11-04 Md Sumon Ali , Muzammil Behzad

Sensitive medical data is often subject to strict usage constraints. In this paper, we trained a generative adversarial network (GAN) on real-world electronic health records (EHR). It was then used to create a data-set of "fake" patients…

Machine Learning · Computer Science 2021-09-07 John Weldon , Tomas Ward , Eoin Brophy

Due to privacy issues and limited amount of publicly available labeled datasets in the domain of medical imaging, we propose an image generation pipeline to synthesize 3D echocardiographic images with corresponding ground truth labels, to…

Image and Video Processing · Electrical Eng. & Systems 2024-03-11 Cristiana Tiago , Andrew Gilbert , Ahmed S. Beela , Svein Arne Aase , Sten Roar Snare , Jurica Sprem

In medical imaging, image synthesis is the estimation process of one image (sequence, modality) from another image (sequence, modality). Since images with different modalities provide diverse biomarkers and capture various features,…

Image and Video Processing · Electrical Eng. & Systems 2023-05-26 Firoozeh Shomal Zadeh , Sevda Molani , Maysam Orouskhani , Marziyeh Rezaei , Mehrzad Shafiei , Hossein Abbasi

Access to medical data is highly restricted due to its sensitive nature, preventing communities from using this data for research or clinical training. Common methods of de-identification implemented to enable the sharing of data are…

Signal Processing · Electrical Eng. & Systems 2019-09-23 Anne Marie Delaney , Eoin Brophy , Tomas E. Ward

Despite the recent success in applying supervised deep learning to medical imaging tasks, the problem of obtaining large and diverse expert-annotated datasets required for the development of high performant models remains particularly…

Computer Vision and Pattern Recognition · Computer Science 2019-11-21 Amirata Ghorbani , Vivek Natarajan , David Coz , Yuan Liu

Machine Learning (ML) has achieved enormous success in solving a variety of problems in computer vision, speech recognition, object detection, to name a few. The principal reason for this success is the availability of huge datasets for…

Cryptography and Security · Computer Science 2023-02-14 Efstathia Soufleri , Gobinda Saha , Kaushik Roy

The proliferation of machine learning models in diverse clinical applications has led to a growing need for high-fidelity, medical image training data. Such data is often scarce due to cost constraints and privacy concerns. Alleviating this…

Image and Video Processing · Electrical Eng. & Systems 2024-10-24 William Cagas , Chan Ko , Blake Hsiao , Shryuk Grandhi , Rishi Bhattacharya , Kevin Zhu , Michael Lam