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Mosquitoes are a major vector for malaria, causing hundreds of thousands of deaths in the developing world each year. Not only is the prevention of mosquito bites of paramount importance to the reduction of malaria transmission cases, but…
One of the main causes of death around the globe is malaria. Researchers have sought to develop predictive models for malaria outbreaks based on meteorological data, climate data and the breeding cycle of Plasmodium, the causative agent of…
Improving the efficiency of malaria diagnosis is one of the main goals of current malaria research. We have recently developed a magneto-optical (MO) method which allows high-sensitivity detection of malaria pigment (hemozoin) crystals via…
Malaria is one of the deadliest infectious diseases globally, causing hundreds of thousands of deaths each year. It disproportionately affects young children, with two-thirds of fatalities occurring in under-fives. Individuals acquire…
Malaria, a mosquito-borne disease caused by a parasite, kills over 1 million people globally each year. People, if left untreated, may develop severe complications, leading to death. Effective and accurate diagnosis is important for the…
We establish some properties of a within host mathematical model of malaria proposed by Recker et al which includes the role of the immune system during the infection. The model accounts for the antigenic variation exhibited by the malaria…
Plasmodium falciparum is responsible for the majority of malaria morbidity and mortality each year. Malaria transmission rates vary by location and time of year due to climate and environmental conditions. We show the impact of these…
Malaria parasites are known to mediate the induction of inflammatory immune responses at the maternal-foetal interface during placental malaria (PM) leading to adverse consequences like pre-term deliveries and abortions. Immunological…
Along the pathogenesis of Mycobacterium Tuberculosis (MTB), hypoxia-induced dormancy is a process involving the oxygen-depleted environment encountered inside the lung granuloma, where bacilli enter a viable, non-replicating state termed as…
Malaria is the one of the leading causes of morbidity and mortality in many developing countries. The development of a highly effective and readily deployable vaccine represents a major goal for world health. There has been recent progress…
Many models of within-host malaria infection dynamics have been formulated since the pioneering work of Anderson et al. in 1989. Biologically, the goal of these models is to understand what governs the severity of infections, the patterns…
We analyze an epidemiological model to evaluate the effectiveness of multiple means of control in malaria-endemic areas. The mathematical model consists of a system of several ordinary differential equations, and is based on a…
Wolbachia infection in Anopheles albimanus mosquitoes can render mosquitoes less capable of spreading malaria. We develop and analyze an ordinary differential equation model to evaluate the effectiveness of Wolbachia-based vector control…
Asymptomatic individuals in the context of malarial disease refers to subjects who carry a parasite load but do not show clinical symptoms. A correct understanding of the influence of asymptomatic individuals on transmission dynamics will…
Determining the distribution of disease prevalence among heterogeneous populations at the national scale is fundamental for epidemiology and public health. Here, we use a combination of methods (spatial scan statistic, topological data…
We introduce an agent-based model describing a susceptible-infectious-susceptible (SIS) system of humans and mosquitoes to predict malaria epidemiological scenarios in realistic biological conditions. Emphasis is given to the transition…
Malaria is a serious infectious disease that is responsible for over half million deaths yearly worldwide. The major cause of these mortalities is late or inaccurate diagnosis. Manual microscopy is currently considered as the dominant…
Wolbachia is possibly the most studied reproductive parasite of arthropod species. It appears to be a promising candidate for biocontrol of some mosquito borne diseases. We begin by developing a sex-structured model for a Wolbachia infected…
Plasmodium falciparum malaria still poses one of the greatest threats to human life with over 200 million cases globally leading to half-million deaths annually. Of these, 90% of cases and of the mortality occurs in sub-Saharan Africa,…
We investigate a model for a mosquito-borne epidemic in which human hosts may adopt protective behaviour against vector bites in response to information on both past and current disease prevalence. Assuming that mosquitoes can also feed on…