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The increasing complexity of industrial scheduling and transport routing problems motivates the study of alternative optimization formulations and computational paradigms. In this work, we study how higher-order unconstrained binary…

With the advances in customized hardware for quantum annealing and digital/CMOS Annealing, Quadratic Unconstrained Binary Optimization (QUBO) models have received growing attention in the optimization literature. Motivated by an existing…

Quantum Physics · Physics 2024-04-05 Oksana Pichugina , Yingcong Tan , Christopher Beck

Current hardware limitations restrict the potential when solving quadratic unconstrained binary optimization (QUBO) problems via the quantum approximate optimization algorithm (QAOA) or quantum annealing (QA). Thus, we consider training…

Quantum Physics · Physics 2020-04-30 Thomas Gabor , Sebastian Feld , Hila Safi , Thomy Phan , Claudia Linnhoff-Popien

Ising machines, including quantum annealing machines, are promising next-generation computers for combinatorial optimization problems. However, due to hardware limitations, most Ising-type hardware can only solve objective functions…

Statistical Mechanics · Physics 2025-10-29 Kazuki Ikeuchi , Yoshiki Matsuda , Shu Tanaka

We demonstrate that the search space of the quadratic assignment problem (QAP), known as an NP-hard combinatorial optimization problem, can be reduced using Grover adaptive search (GAS) with permutation preparation operator (PPO). To that…

In materials informatics, searching for chemical materials with desired properties is challenging due to the vastness of the chemical space. Moreover, the high cost of evaluating properties necessitates a search with a few clues. In…

Quantum Physics · Physics 2023-12-18 Mikiya Doi , Yoshihiro Nakao , Takuro Tanaka , Masami Sako , Masayuki Ohzeki

Digital Annealer (DA) is a computer architecture designed for tackling combinatorial optimization problems formulated as quadratic unconstrained binary optimization (QUBO) models. In this paper, we present the results of an extensive…

Optimization and Control · Mathematics 2020-12-24 Oylum Şeker , Neda Tanoumand , Merve Bodur

Feature selection is a machine learning technique for identifying relevant variables in classification and regression models. In single-cell RNA sequencing (scRNA-seq) data analysis, feature selection is used to identify relevant genes that…

Genomics · Quantitative Biology 2025-12-02 Selim Romero , Shreyan Gupta , Victoria Gatlin , Robert S. Chapkin , James J. Cai

Density matrix electronic structure theory is used in many quantum chemistry methods to "alleviate" the computational cost that arises from directly using wave functions. Although density matrix based methods are computationally more…

The efficient calculation of the centrality or "hierarchy" of nodes in a network has gained great relevance in recent years due to the generation of large amounts of data. The eigenvector centrality (aka eigencentrality) is quickly becoming…

We introduce VeloxQ, a fast solver for Quadratic Unconstrained Binary Optimization (QUBO) problems, which are central to many real-world optimization tasks. Unlike approaches that depend on emerging quantum hardware, VeloxQ can be deployed…

Quantum Physics · Physics 2026-05-05 J. Pawłowski , J. Tuziemski , P. Tarasiuk , H. Louzada , R. Adamski , K. Hendzel , Ł. Pawela , B. Gardas

The routing and wavelength assignment with protection is an important problem in telecommunications. Given an optical network and incoming connection requests, a commonly studied variant of the problem aims to grant maximum number of…

Optimization and Control · Mathematics 2021-06-09 Oylum Şeker , Merve Bodur , Hamed Pouya

Quantum computing and modern tensor-based computing have a strong connection, which is especially demonstrated by simulating quantum computations with tensor networks. The other direction is less studied: quantum computing is not often…

Quantum Physics · Physics 2025-09-03 Valter Uotila

We introduce a novel Quadratic Unconstrained Binary Optimization (QUBO) formulation method for spanning tree problems. Instead of encoding the presence of edges in the tree individually, we opt to encode spanning trees as a permutation…

Data Structures and Algorithms · Computer Science 2022-09-13 Ivan Carvalho

Black-box optimization (BBO) can be used to optimize functions whose analytic form is unknown. A common approach to realising BBO is to learn a surrogate model which approximates the target black-box function which can then be solved via…

Machine Learning · Computer Science 2023-02-10 Jonas Nüßlein , Christoph Roch , Thomas Gabor , Jonas Stein , Claudia Linnhoff-Popien , Sebastian Feld

We present a method to formulate the unit commitment problem in energy production as quadratic unconstrained binary optimization (QUBO) problem, which can be solved by classical algorithms and quantum computers. We suggest a first approach…

Quantum Physics · Physics 2023-01-04 M. C. Braun , T. Decker , N. Hegemann , S. F. Kerstan , F. Lorenz

Encoding combinatorial optimization problems into physically meaningful Hamiltonians with tractable energy landscapes forms the foundation of quantum optimization. Numerous works have studied such efficient encodings for the class of…

Quantum Physics · Physics 2026-02-12 Sebastian Egginger , Kristina Kirova , Sonja Bruckner , Stefan Hillmich , Richard Kueng

Many of the envisioned use-cases for quantum computers involve optimisation processes. While there are many algorithmic primitives to perform the required calculations, all eventually lead to quantum gates operating on quantum bits, with an…

Quantum Physics · Physics 2026-03-26 Lukas Schmidbauer , Elisabeth Lobe , Ina Schaefer , Wolfgang Mauerer

Diagnosing the minimal set of faults capable of explaining a set of given observations, e.g., from sensor readouts, is a hard combinatorial optimization problem usually tackled with artificial intelligence techniques. We present the mapping…

In this paper, we present a new method to solve a certain type of Semidefinite Programming (SDP) problems. These types of SDPs naturally arise in the Quadratic Convex Reformulation (QCR) method and can be used to obtain dual bounds of…

Optimization and Control · Mathematics 2023-12-27 Apostolos Chalkis , Thomas Kleinert , Boro Sofranac