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Biomedical knowledge graphs (KG) are heterogenous networks consisting of biological entities as nodes and relations between them as edges. These entities and relations are extracted from millions of research papers and unified in a single…

Artificial Intelligence · Computer Science 2022-11-11 Dattaraj J. Rao , Shraddha S. Mane , Mukta A. Paliwal

Knowledge graphs play a vital role in numerous artificial intelligence tasks, yet they frequently face the issue of incompleteness. In this study, we explore utilizing Large Language Models (LLM) for knowledge graph completion. We consider…

Computation and Language · Computer Science 2025-02-14 Liang Yao , Jiazhen Peng , Chengsheng Mao , Yuan Luo

Causal discovery aims to estimate causal structures among variables based on observational data. Large Language Models (LLMs) offer a fresh perspective to tackle the causal discovery problem by reasoning on the metadata associated with…

Computation and Language · Computer Science 2024-07-31 Yuni Susanti , Michael Färber

Knowledge graphs (KGs) have commonly been constructed using predefined symbolic relation schemas, typically implemented as categorical relation labels. This design has notable shortcomings: real-world relations are often contextual,…

Computation and Language · Computer Science 2026-01-15 Kanyao Han , Yushang Lai

Knowledge Graphs (KGs) have gained considerable attention recently from both academia and industry. In fact, incorporating graph technology and the copious of various graph datasets have led the research community to build sophisticated…

Artificial Intelligence · Computer Science 2020-06-03 Bilal Abu-Salih , Marwan Al-Tawil , Ibrahim Aljarah , Hossam Faris , Pornpit Wongthongtham

Despite the recent popularity of knowledge graph (KG) related tasks and benchmarks such as KG embeddings, link prediction, entity alignment and evaluation of the reasoning abilities of pretrained language models as KGs, the structure and…

Machine Learning · Computer Science 2023-11-14 Nedelina Teneva , Estevam Hruschka

Biomedical Knowledge Graphs (BKGs) integrate diverse datasets to elucidate complex relationships within the biomedical field. Effective link prediction on these graphs can uncover valuable connections, such as potential novel drug-disease…

Computation and Language · Computer Science 2025-07-01 Tien Dang , Viet Thanh Duy Nguyen , Minh Tuan Le , Truong-Son Hy

The rapid advancement of large language models (LLMs) has opened new boundaries in the extraction and synthesis of medical knowledge, particularly within evidence synthesis. This paper reviews the state-of-the-art applications of LLMs in…

We study how to impose domain-consistent structure on large language models (LLMs) used for scientific reasoning and early-stage drug discovery. We present MedRule-KG, a compact knowledge-graph scaffold paired with a lightweight verifier…

Artificial Intelligence · Computer Science 2025-12-15 Crystal Su

Drug repurposing plays a critical role in accelerating treatment discovery, especially for complex and rare diseases. Biomedical knowledge graphs (KGs), which encode rich clinical associations, have been widely adopted to support this task.…

Computation and Language · Computer Science 2025-10-15 Chengrui Xiang , Tengfei Ma , Xiangzheng Fu , Yiping Liu , Bosheng Song , Xiangxiang Zeng

Knowledge Graph Completion has been increasingly adopted as a useful method for helping address several tasks in biomedical research, such as drug repurposing or drug-target identification. To that end, a variety of datasets and Knowledge…

Machine Learning · Computer Science 2025-11-07 Alberto Cattaneo , Stephen Bonner , Thomas Martynec , Edward Morrissey , Carlo Luschi , Ian P Barrett , Daniel Justus

Knowledge Graphs (KGs) have found many applications in industry and academic settings, which in turn, have motivated considerable research efforts towards large-scale information extraction from a variety of sources. Despite such efforts,…

Machine Learning · Computer Science 2021-01-25 Andrea Rossi , Donatella Firmani , Antonio Matinata , Paolo Merialdo , Denilson Barbosa

Knowledge Graph (KG) can effectively integrate valuable information from massive data, and thus has been rapidly developed and widely used in many fields. Traditional KG construction methods rely on manual annotation, which often consumes a…

Computation and Language · Computer Science 2026-04-22 Qiubai Zhu , Qingwang Wang , Haibin Yuan , Wei Chen , Tao Shen

Learning low-dimensional embeddings of knowledge graphs is a powerful approach used to predict unobserved or missing edges between entities. However, an open challenge in this area is developing techniques that can go beyond simple edge…

Social and Information Networks · Computer Science 2019-10-30 William L. Hamilton , Payal Bajaj , Marinka Zitnik , Dan Jurafsky , Jure Leskovec

Knowledge graphs (KGs) are increasingly used to represent biomedical information in structured, interpretable formats. However, existing biomedical KGs often focus narrowly on molecular interactions or adverse events, overlooking the rich…

Artificial Intelligence · Computer Science 2025-10-01 Asmita Sengupta , David Antony Selby , Sebastian Josef Vollmer , Gerrit Großmann

Knowledge Graphs (KGs) serving as semantic networks, prove highly effective in managing complex interconnected data in different domains, by offering a unified, contextualized, and structured representation with flexibility that allows for…

Computation and Language · Computer Science 2024-10-01 Azmine Toushik Wasi

This paper presents an exhaustive quantitative and qualitative evaluation of Large Language Models (LLMs) for Knowledge Graph (KG) construction and reasoning. We engage in experiments across eight diverse datasets, focusing on four…

Computation and Language · Computer Science 2024-12-30 Yuqi Zhu , Xiaohan Wang , Jing Chen , Shuofei Qiao , Yixin Ou , Yunzhi Yao , Shumin Deng , Huajun Chen , Ningyu Zhang

Knowledge-enhanced language representation learning has shown promising results across various knowledge-intensive NLP tasks. However, prior methods are limited in efficient utilization of multilingual knowledge graph (KG) data for language…

Computation and Language · Computer Science 2022-10-20 Linlin Liu , Xin Li , Ruidan He , Lidong Bing , Shafiq Joty , Luo Si

Drug repurposing is often framed as a candidate identification task, but existing approaches provide limited guidance for distinguishing biologically plausible candidates from historically well-connected ones. Here we introduce DrugKLM, a…

Large language models (LLMs) have garnered significant attention for their superior performance in many knowledge-driven applications on the world wide web.These models are designed to train hundreds of millions or more parameters on large…

Computation and Language · Computer Science 2025-04-09 Bingchen Liu , Yuanyuan Fang , Naixing Xu , Shihao Hou , Xin Li , Qian Li