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Testing composite null hypotheses arises in various applications, such as mediation and replicability analyses. The problem becomes more challenging in high-throughput experiments where tens of thousands of features are examined…

Methodology · Statistics 2025-04-29 Pengfei Lyu , Xianyang Zhang , Hongyuan Cao

In many scenarios such as genome-wide association studies where dependences between variables commonly exist, it is often of interest to infer the interaction effects in the model. However, testing pairwise interactions among millions of…

Methodology · Statistics 2022-09-02 Jingyi Duan , Yang Ning , Xi Chen , Yong Chen

The application of machine learning (ML) to electroencephalography (EEG) has great potential to advance both neuroscientific research and clinical applications. However, the generalisability and robustness of EEG-based ML models often hinge…

Signal Processing · Electrical Eng. & Systems 2025-11-03 Philipp Bomatter , Henry Gouk

Sleep staging plays an important role on the diagnosis of sleep disorders. In general, experts classify sleep stages manually based on polysomnography (PSG), which is quite time-consuming. Meanwhile, the acquisition process of multiple…

Machine Learning · Computer Science 2021-08-17 Huafeng Wang , Chonggang Lu , Qi Zhang , Zhimin Hu , Xiaodong Yuan , Pingshu Zhang , Wanquan Liu

The identification of the dependent components in multiple data sets is a fundamental problem in many practical applications. The challenge in these applications is that often the data sets are high-dimensional with few observations or…

Methodology · Statistics 2023-06-02 Martin Gölz , Tanuj Hasija , Michael Muma , Abdelhak M. Zoubir

Motivated by recent findings in Li and Zhang (2025), which established an equivalence between certain p-value-based multiple testing procedures and the e-Benjamini-Hochberg procedure (Wang and Ramdas, 2022), we introduce a general framework…

Methodology · Statistics 2025-08-22 Guanxun Li , Xianyang Zhang

This paper is motivated by a regression analysis of electroencephalography (EEG) neuroimaging data with high-dimensional correlated responses with multi-level nested correlations. We develop a divide-and-conquer procedure implemented in a…

Methodology · Statistics 2020-05-29 Emily C. Hector , Peter X. -K. Song

Electroencephalography (EEG) is an objective tool for emotion recognition and shows promising performance. However, the label scarcity problem is a main challenge in this field, which limits the wide application of EEG-based emotion…

Signal Processing · Electrical Eng. & Systems 2024-09-02 Rushuang Zhou , Weishan Ye , Zhiguo Zhang , Yanyang Luo , Li Zhang , Linling Li , Gan Huang , Yining Dong , Yuan-Ting Zhang , Zhen Liang

Deep learning models have shown promise in EEG-based outcome prediction for comatose patients after cardiac arrest, but their reliability is often compromised by subtle forms of data leakage. In particular, when long EEG recordings are…

Machine Learning · Computer Science 2026-03-30 Yixin Zhou , Zhixiang Liu , Vladimir I. Zadorozhny , Jonathan Elmer

The estimation of functional networks through functional covariance and graphical models have recently attracted increasing attention in settings with high dimensional functional data, where the number of functional variables p is…

Statistics Theory · Mathematics 2024-09-05 Qin Fang , Qing Jiang , Xinghao Qiao

Voxel-based multiple testing is widely used in neuroimaging data analysis. Traditional false discovery rate (FDR) control methods often ignore the spatial dependence among the voxel-based tests and thus suffer from substantial loss of…

Machine Learning · Statistics 2024-05-06 Taehyo Kim , Hai Shu , Qiran Jia , Mony J. de Leon

We consider the problem of extracting features from passive, multi-channel electroencephalogram (EEG) devices for downstream inference tasks related to high-level mental states such as stress and cognitive load. Our proposed method…

Signal Processing · Electrical Eng. & Systems 2022-03-02 Guodong Chen , Hayden S. Helm , Kate Lytvynets , Weiwei Yang , Carey E. Priebe

Data for several applications in diverse fields can be represented as multiple matrices that are linked across rows or columns. This is particularly common in molecular biomedical research, in which multiple molecular "omics" technologies…

Machine Learning · Statistics 2024-08-02 Eric F. Lock

With the widespread application of electroencephalography (EEG) in neuroscience and clinical practice, efficiently retrieving and semantically interpreting large-scale, multi-source, heterogeneous EEG data has become a pressing challenge.…

Computation and Language · Computer Science 2025-10-14 Yi Wang , Haoran Luo , Lu Meng , Ziyu Jia , Xinliang Zhou , Qingsong Wen

This paper deals with the problem of simultaneously making many (M) binary decisions based on one realization of a random data matrix X. M is typically large and X will usually have M rows associated with each of the M decisions to make,…

Statistics Theory · Mathematics 2015-03-19 Wensong Wu , Edsel A. Peña

Assessment of mental workload in real-world conditions is key to ensure the performance of workers executing tasks that demand sustained attention. Previous literature has employed electroencephalography (EEG) to this end despite having…

Machine Learning · Computer Science 2024-10-30 Isabela Albuquerque , João Monteiro , Olivier Rosanne , Abhishek Tiwari , Jean-François Gagnon , Tiago H. Falk

Continuous electroencephalography (EEG) is routinely used in neurocritical care to monitor seizures and other harmful brain activity, including rhythmic and periodic patterns that are clinically significant. Although deep learning methods…

Human-Computer Interaction · Computer Science 2026-01-05 Argha Kamal Samanta , Deepak Mewada , Monalisa Sarma , Debasis Samanta

In modern scientific experiments, we frequently encounter data that have large dimensions, and in some experiments, such high dimensional data arrive sequentially rather than full data being available all at a time. We develop multiple…

Methodology · Statistics 2023-06-09 Rahul Roy , Shyamal K. De , Subir Kumar Bhandari

Electroencephalogram (EEG) classification has been widely used in various medical and engineering applications, where it is important for understanding brain function, diagnosing diseases, and assessing mental health conditions. However,…

Signal Processing · Electrical Eng. & Systems 2024-08-20 Mingzhi Chen , Yiyu Gui , Yuqi Su , Yuesheng Zhu , Guibo Luo , Yuchao Yang

Current source density (CSD) power asymmetry, a measure derived from electroencephalography (EEG), is a potential biomarker for major depressive disorder (MDD). Though this measure is functional in nature (defined on the frequency domain),…

Applications · Statistics 2020-12-07 Adam Ciarleglio , Eva Petkova , Ofer Harel