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Single-cell RNA sequencing has transformed biology by enabling the measurement of gene expression at cellular resolution, providing information for cell types, states, and disease contexts. Recently, single-cell foundation models have…

Machine Learning · Computer Science 2025-10-13 Oussama Kharouiche , Aris Markogiannakis , Xiao Fei , Michail Chatzianastasis , Michalis Vazirgiannis

Active learning is usually applied to acquire labels of informative data points in supervised learning, to maximize accuracy in a sample-efficient way. However, maximizing the accuracy is not the end goal when the results are used for…

Machine Learning · Statistics 2021-10-22 Louis Filstroff , Iiris Sundin , Petrus Mikkola , Aleksei Tiulpin , Juuso Kylmäoja , Samuel Kaski

Vision-language models (VLMs) have demonstrated remarkable zero-shot performance across various classification tasks. Nonetheless, their reliance on hand-crafted text prompts for each task hinders efficient adaptation to new tasks. While…

Computer Vision and Pattern Recognition · Computer Science 2026-03-11 Hoyoung Kim , Seokhee Jin , Changhwan Sung , Jaechang Kim , Jungseul Ok

In supervised learning for medical image analysis, sample selection methodologies are fundamental to attain optimum system performance promptly and with minimal expert interactions (e.g. label querying in an active learning setup). In this…

Computer Vision and Pattern Recognition · Computer Science 2021-04-14 Dwarikanath Mahapatra

According to the National Cancer Institute, there were 9.5 million cancer-related deaths in 2018. A challenge in improving treatment is resistance in genetically unstable cells. The purpose of this study is to evaluate unsupervised machine…

Genomics · Quantitative Biology 2021-08-12 Anastasia Dunca , Frederick R. Adler

Understanding how genetic variants influence cellular-level processes is an important step towards understanding how they influence important organismal-level traits, or "phenotypes", including human disease susceptibility. To this end…

Methodology · Statistics 2013-07-30 Heejung Shim , Matthew Stephens

Modern computing and communication technologies can make data collection procedures very efficient. However, our ability to analyze large data sets and/or to extract information out from them is hard-pressed to keep up with our capacities…

Machine Learning · Statistics 2019-01-30 Zhanfeng Wang , Yumi Kwon , Yuan-chin Ivan Chang

Small nucleolar RNAs (snoRNAs) are increasingly recognized for their critical role in the pathogenesis and characterization of various human diseases. Consequently, the precise identification of snoRNA-disease associations (SDAs) is…

Machine Learning · Computer Science 2025-05-13 Ummay Maria Muna , Fahim Hafiz , Shanta Biswas , Riasat Azim

Identification of every single genome present in a microbial sample is an important and challenging task with crucial applications. It is challenging because there are typically millions of cells in a microbial sample, the vast majority of…

Genomics · Quantitative Biology 2014-04-29 Zeinab Taghavi , Narjes S. Movahedi , Sorin Draghici , Hamidreza Chitsaz

Sketch recognition allows natural and efficient interaction in pen-based interfaces. A key obstacle to building accurate sketch recognizers has been the difficulty of creating large amounts of annotated training data. Several authors have…

Computer Vision and Pattern Recognition · Computer Science 2019-03-08 Erelcan Yanik , Tevfik Metin Sezgin

Automated skin lesion analysis is very crucial in clinical practice, as skin cancer is among the most common human malignancy. Existing approaches with deep learning have achieved remarkable performance on this challenging task, however,…

Computer Vision and Pattern Recognition · Computer Science 2019-09-06 Xueying Shi , Qi Dou , Cheng Xue , Jing Qin , Hao Chen , Pheng-Ann Heng

Sequence set is a widely-used type of data source in a large variety of fields. A typical example is protein structure prediction, which takes an multiple sequence alignment (MSA) as input and aims to infer structural information from it.…

Biomolecules · Quantitative Biology 2019-06-27 Fusong Ju , Jianwei Zhu , Guozheng Wei , Qi Zhang , Shiwei Sun , Dongbo Bu

Single-cell RNA sequencing (scRNA-seq) technology enables systematic delineation of cellular states and interactions, providing crucial insights into cellular heterogeneity. Building on this potential, numerous computational methods have…

Genomics · Quantitative Biology 2025-11-11 Ping Xu , Zaitian Wang , Zhirui Wang , Pengjiang Li , Ran Zhang , Gaoyang Li , Hanyu Xie , Jiajia Wang , Yuanchun Zhou , Pengfei Wang

Complete genome sequences contain valuable information about natural selection, but extracting this information for short, widely scattered noncoding elements remains a challenging problem. Here we introduce a new computational method for…

Genomics · Quantitative Biology 2015-03-19 Ilan Gronau , Leonardo Arbiza , Jaaved Mohammed , Adam Siepel

Few-shot learning is a challenging problem since only a few examples are provided to recognize a new class. Several recent studies exploit additional semantic information, e.g. text embeddings of class names, to address the issue of rare…

Computer Vision and Pattern Recognition · Computer Science 2023-03-27 Wentao Chen , Chenyang Si , Zhang Zhang , Liang Wang , Zilei Wang , Tieniu Tan

The need to count and localize repeating objects in an image arises in different scenarios, such as biological microscopy studies, production lines inspection, and surveillance recordings analysis. The use of supervised Convoutional Neural…

Computer Vision and Pattern Recognition · Computer Science 2021-11-17 Inbar Huberman-Spiegelglas , Raanan Fattal

Deep learning, a rebranding of deep neural network research works, has achieved a remarkable success in recent years. With multiple hidden layers, deep learning models aim at computing the hierarchical feature representations of the…

Neural and Evolutionary Computing · Computer Science 2018-06-06 Jiawei Zhang , Limeng Cui , Fisher B. Gouza

Single-cell RNA sequencing (scRNA-seq), especially temporally resolved datasets, enables genome-wide profiling of gene expression dynamics at single-cell resolution across discrete time points. However, current technologies provide only…

Genomics · Quantitative Biology 2025-11-19 Yue Ling , Peiqi Zhang , Zhenyi Zhang , Peijie Zhou

Precise classification of megakaryocytes is crucial for diagnosing myelodysplastic syndromes. Although self-supervised learning has shown promise in medical image analysis, its application to classifying megakaryocytes in stained slides…

Computer Vision and Pattern Recognition · Computer Science 2025-05-21 Linghao Zhuang , Ying Zhang , Gege Yuan , Xingyue Zhao , Zhiping Jiang

Active learning is of great interest for many practical applications, especially in industry and the physical sciences, where there is a strong need to minimize the number of costly experiments necessary to train predictive models. However,…

Machine Learning · Computer Science 2021-12-23 Maryam Pardakhti , Nila Mandal , Anson W. K. Ma , Qian Yang