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This thesis centres on the development of multidimensional fluorescence imaging tools, with a particular emphasis on fluorescence lifetime imaging (FLIM) microscopy for application to biological research. The key aspects of this thesis are…

Instrumentation and Detectors · Physics 2017-08-14 Egidijus Auksorius

Background and Objective: Nowadays usage paradigms of medical imaging resources are requesting vendor-neutral archives, accessible through standard interfaces, with multi-repository support. Regional repositories shared by distinct…

Software Engineering · Computer Science 2020-06-24 Rui Lebre , Luís Bastião , Carlos Costa

Summary: Data management in clinical metabolomics studies is often inadequate. To improve this situation we created LabPipe to provide a guided, customisable approach to study-specific sample collection. It is driven through a local client…

Optofluidic devices have revolutionized the manipulation and transportation of fluid at smaller length scales ranging from micrometers to millimeters. We describe a dedicated optical setup for studying laser-induced cavitation inside a…

Polarized light microscopy provides unique opportunities for analyzing the molecular order in man-made and natural materials, including biological structures inside living cells, tissues, and whole organisms. 20 years ago, the LC-PolScope…

Optics · Physics 2015-06-16 Shalin B. Mehta , Michael Shribak , Rudolf Oldenbourg

Photoacoustic (PA) imaging systems based on clinical linear ultrasound arrays have become increasingly popular in translational PA research. Such systems can be more easily integrated in a clinical workflow due to the simultaneous access to…

Recently proposed modifications of the standard particle-in-cell (PIC) method resolve long-standing limitations such as exact preservation of physically conserved quantities and unbiased ensemble down-sampling. Such advances pave the way…

Plasma Physics · Physics 2026-03-13 Frida Brogren , Christoffer Olofsson , Joel Magnusson , Arkady Gonoskov

Visualizing and navigating through large astronomy images from a remote location with current astronomy display tools can be a frustrating experience in terms of speed and ergonomics, especially on mobile devices. In this paper, we present…

Instrumentation and Methods for Astrophysics · Physics 2015-02-06 Emmanuel Bertin , Ruven Pillay , Chiara Marmo

This article describes an implementation of low-cost portable touch screen technology, applied to university teaching, using as a base the remote control of the Nintendo Wii console (known as Wiimote), a normal projector, a computer and…

Human-Computer Interaction · Computer Science 2022-07-20 Navas-López , Eduardo Adam

We present Clinica (www.clinica.run), an open-source software platform designed to make clinical neuroscience studies easier and more reproducible. Clinica aims for researchers to i) spend less time on data management and processing, ii)…

SMeagol is a software tool to simulate highly realistic microscopy data based on spatial systems biology models, in order to facilitate development, validation, and optimization of advanced analysis methods for live cell single molecule…

Biological Physics · Physics 2017-05-08 Martin Lindén , Vladimir Ćurić , Alexis Boucharin , David Fange , Johan Elf

We report on the software architecture we developed for the Open University's remotely controlled telescope PIRATE. This facility is based in Mallorca and used in distance learning modules by undergraduate students and by postgraduate…

Instrumentation and Methods for Astrophysics · Physics 2010-12-15 Robert Lucas , Ulrich Kolb

Recently, it was discovered that microsphere can generate super-resolution focusing beyond diffraction limit. This has led to the development of an exciting super-resolution imaging technique -microsphere nanoscopy- that features a record…

Optics · Physics 2021-08-26 Zengbo Wang

The proliferation of microscopy methods for live-cell imaging offers many new possibilities for users but can also be challenging to navigate. We focus here on computational methods that promise to boost live-cell fluorescence microscopy,…

Quantitative Methods · Quantitative Biology 2024-01-04 Hari Shroff , Ilaria Testa , Florian Jug , Suliana Manley

Virtualization technology allows currently any application run any application complex and expensive computational (the scientific applications are a good example) on heterogeneous distributed systems, which make regular use of Grid and…

Distributed, Parallel, and Cluster Computing · Computer Science 2011-08-03 Tomas Ramirez Picarzo , Francisco Fernandez de Vega , Daniel Lombrana Gonzalez

Since most developed countries are facing an increase in the number of patients per healthcare worker due to a declining birth rate and an aging population, relatively simple and safe diagnosis tasks may need to be performed using robotics…

Robotics · Computer Science 2022-10-31 Ryosuke Tsumura , Yoshihiko Koseki , Naotaka Nitta , Kiyoshi Yoshinaka

Imaging-based, non-contact measurement of physiology (including imaging photoplethysmography and imaging ballistocardiography) is a growing field of research. There are several strengths of imaging methods that make them attractive. They…

Computer Vision and Pattern Recognition · Computer Science 2019-01-15 Daniel McDuff , Ethan Blackford

Spatial transcriptomics methods capture cellular measurements such as gene expression and cell types at specific locations in a cell, helping provide a localized picture of tissue health. Traditional visualization techniques superimpose the…

Quantitative Methods · Quantitative Biology 2024-10-16 Siyuan Zhao , G. Elisabeta Marai

Laboratory measurements often use several instruments to fully explore the relevant parameter space; such as, an external lock-in amplifier, an electromagnet, an RF generator, etc.. Ordinarily, these instruments have to be individually…

Instrumentation and Detectors · Physics 2024-06-25 Brad M. Goff , Jay A. Gupta

Computer simulations have become a very powerful tool for scientific research. Given the vast complexity that comes with many open scientific questions, a purely analytical or experimental approach is often not viable. For example,…

Neural and Evolutionary Computing · Computer Science 2016-07-12 Roman Bauer , Lukas Breitwieser , Alberto Di Meglio , Leonard Johard , Marcus Kaiser , Marco Manca , Manuel Mazzara , Max Talanov