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Motivated by recent data analyses in biomedical imaging studies, we consider a class of image-on-scalar regression models for imaging responses and scalar predictors. We propose using flexible multivariate splines over triangulations to…

Methodology · Statistics 2021-06-04 Shan Yu , Guannan Wang , Li Wang , Lijian Yang

Alzheimer's disease (AD) is a chronic neurodegenerative condition responsible for most cases of dementia and considered as one of the greatest challenges for neuroscience in this century. Early Ad signs are usually mistaken for normal…

Neurons and Cognition · Quantitative Biology 2021-02-08 Juan A. Arias , Carmen Cadarso-Suárez , Pablo Aguiar-Fernández

Inference via simultaneous confidence band is studied for stationary covariance function of dense functional data. A two-stage estimation procedure is proposed based on spline approximation, the first stage involving estimation of all the…

Methodology · Statistics 2019-10-31 Jiangyan Wang , Guanqun Cao , Li Wang , Lijian Yang

Quantifying uncertainty using confidence regions is a central goal of statistical inference. Despite this, methodologies for confidence bands in Functional Data Analysis are still underdeveloped compared to estimation and hypothesis…

Methodology · Statistics 2022-11-14 Dominik Liebl , Matthew Reimherr

Covariance estimation is essential yet underdeveloped for analyzing multivariate functional data. We propose a fast covariance estimation method for multivariate sparse functional data using bivariate penalized splines. The tensor-product…

Methodology · Statistics 2019-06-11 Cai Li , Luo Xiao , Sheng Luo

We aim to develop simultaneous inference tools for the mean function of functional data from sparse to dense. First, we derive a unified Gaussian approximation to construct simultaneous confidence bands of mean functions based on the…

Methodology · Statistics 2024-02-01 Leheng Cai , Qirui Hu

Smoothing of noisy sample covariances is an important component in functional data analysis. We propose a novel covariance smoothing method based on penalized splines and associated software. The proposed method is a bivariate spline…

Methodology · Statistics 2017-04-07 Luo Xiao , Cai Li , William Checkley , Ciprian M. Crainiceanu

The prevalence of spatially referenced multivariate data has impelled researchers to develop a procedure for the joint modeling of multiple spatial processes. This ordinarily involves modeling marginal and cross-process dependence for any…

Methodology · Statistics 2020-07-10 Ghulam A. Qadir , Ying Sun

In this paper we propose a novel method for the segmentation of longitudinal brain MRI scans of patients suffering from Multiple Sclerosis. The method builds upon an existing cross-sectional method for simultaneous whole-brain and lesion…

Image and Video Processing · Electrical Eng. & Systems 2021-01-05 Stefano Cerri , Andrew Hoopes , Douglas N. Greve , Mark Mühlau , Koen Van Leemput

This article is motivated by studying multisensory effects on brain activities in intracranial electroencephalography (iEEG) experiments. Differential brain activities to multisensory stimulus presentations are zero in most regions and…

Methodology · Statistics 2022-06-01 Zhengjia Wang , John Magnotti , Michael S. Beauchamp , Meng Li

Parallel imaging techniques reduce magnetic resonance imaging (MRI) scan time but image quality degrades as the acceleration factor increases. In clinical practice, conservative acceleration factors are chosen because no mechanism exists to…

Image and Video Processing · Electrical Eng. & Systems 2026-05-26 Ilias I. Giannakopoulos , Lokesh B Gautham Muthukumar , Yvonne W. Lui , Riccardo Lattanzi

We propose a novel approach to image segmentation based on combining implicit spline representations with deep convolutional neural networks. This is done by predicting the control points of a bivariate spline function whose zero-set…

Image and Video Processing · Electrical Eng. & Systems 2021-03-22 Oliver J. D. Barrowclough , Georg Muntingh , Varatharajan Nainamalai , Ivar Stangeby

Motivated by recent work involving the analysis of leveraging spatial correlations in sparsified mean estimation, we present a novel procedure for constructing covariance estimator. The proposed Random-knots (Random-knots-Spatial) and…

Methodology · Statistics 2025-11-25 Sijie Zheng , Fandong Meng , Jie Zhou

We consider nonparametric regression in the context of functional data, that is, when a random sample of functions is observed on a fine grid. We obtain a functional asymptotic normality result allowing to build simultaneous confidence…

Methodology · Statistics 2015-03-13 David A. Degras

In this paper, we study the estimation of partially linear models for spatial data distributed over complex domains. We use bivariate splines over triangulations to represent the nonparametric component on an irregular two-dimensional…

Statistics Theory · Mathematics 2021-06-03 Li Wang , Guannan Wang , Min-Jun Lai , Lei Gao

In Functional Data Analysis, data are commonly assumed to be smooth functions on a fixed interval of the real line. In this work, we introduce a comprehensive framework for the analysis of functional data, whose domain is a two-dimensional…

Methodology · Statistics 2019-08-02 Eardi Lila , John A. D. Aston

Simultaneous functional PET/MR (sf-PET/MR) presents a cutting-edge multimodal neuroimaging technique. It provides an unprecedented opportunity for concurrently monitoring and integrating multifaceted brain networks built by spatiotemporally…

Image and Video Processing · Electrical Eng. & Systems 2024-09-23 Luoyu Wang , Yitian Tao , Qing Yang , Yan Liang , Siwei Liu , Hongcheng Shi , Dinggang Shen , Han Zhang

Estimation of the mean and covariance parameters for functional data is a critical task, with local linear smoothing being a popular choice. In recent years, many scientific domains are producing multivariate functional data for which $p$,…

Statistics Theory · Mathematics 2024-09-24 Alexander Petersen

There has been much progress in data-driven artificial intelligence technology for medical image analysis in the last decades. However, it still remains challenging due to its distinctive complexity of acquiring and annotating image data,…

Computer Vision and Pattern Recognition · Computer Science 2021-06-30 Chao Gou , Tianyu Shen , Wenbo Zheng , Huadan Xue , Hui Yu , Qiang Ji , Zhengyu Jin , Fei-Yue Wang

Positron Emission Tomography (PET) scan images are one of the bio medical imaging techniques similar to that of MRI scan images but PET scan images are helpful in finding the development of tumors.The PET scan images requires expertise in…

Neural and Evolutionary Computing · Computer Science 2013-02-27 A. Meena , K. Raja
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