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Drug discovery is a multi-stage process that comprises two costly major steps: pre-clinical research and clinical trials. Among its stages, lead optimization easily consumes more than half of the pre-clinical budget. We propose a combined…

Machine Learning · Computer Science 2020-11-30 Leili Zhang , Giacomo Domeniconi , Chih-Chieh Yang , Seung-gu Kang , Ruhong Zhou , Guojing Cong

While multi-joint continuum robots are highly dexterous and flexible, designing an optimal robot can be challenging due to its kinematics involving curvatures. Hence, the current work presents a computational method developed to find…

Robotics · Computer Science 2025-03-17 Hyunmin Cheong , Mehran Ebrahimi , Timothy Duggan

Deep learning has been widely used in various applications from different fields such as computer vision, natural language processing, etc. However, the training models are often manually developed via many costly experiments. This manual…

Machine Learning · Computer Science 2022-11-22 Thanh Phuong Pham

Quality-Diversity (QD) optimisation is a new family of learning algorithms that aims at generating collections of diverse and high-performing solutions. Among those algorithms, the recently introduced Covariance Matrix Adaptation MAP-Elites…

Neural and Evolutionary Computing · Computer Science 2021-07-07 Antoine Cully

This paper introduces a new method of partitioning the solution space of a multi-objective optimisation problem for parallel processing, called Efficient Projection Partitioning. This method projects solutions down into a single dimension,…

Optimization and Control · Mathematics 2017-11-23 William Pettersson , Melih Ozlen

In this experience report, we apply deep active learning to the field of design optimization to reduce the number of computationally expensive numerical simulations. We are interested in optimizing the design of structural components, where…

Machine Learning · Computer Science 2024-03-21 Jens Decke , Christian Gruhl , Lukas Rauch , Bernhard Sick

Multi-objective evolutionary algorithms (MOEAs) have become essential tools for solving multi-objective optimization problems (MOPs), making their running time analysis crucial for assessing algorithmic efficiency and guiding practical…

Neural and Evolutionary Computing · Computer Science 2025-07-04 Han Huang , Tianyu Wang , Chaoda Peng , Tongli He , Zhifeng Hao

This paper presents a novel framework for optimizing capacitor selection in electronic design using multi-objective linear and non-linear constrained optimization techniques. We demonstrate the effectiveness of this approach in minimizing…

Systems and Control · Electrical Eng. & Systems 2025-07-23 Luke Brantingham , Jason Grover

Software architecture optimization aims to enhance non-functional attributes like performance and reliability while meeting functional requirements. Multi-objective optimization employs metaheuristic search techniques, such as genetic…

Comprehensive quality-aware automated semantic web service composition is an NP-hard problem, where service composition workflows are unknown, and comprehensive quality, i.e., Quality of services (QoS) and Quality of semantic matchmaking…

Artificial Intelligence · Computer Science 2022-01-26 Chen Wang , Hui Ma , Gang Chen , Sven Hartmann

Sparse linear system solvers ($Ax=b$) are critical computational kernels in Electronic Design Automation (EDA), underpinning vital simulations for modern IC and system design. Applications like power integrity verification and…

Numerical Analysis · Mathematics 2025-04-17 Nityanand Rai

Managing complex Cyber-Physical Energy Systems (CPES) requires solving various optimization problems with multiple objectives and constraints. As distributed control architectures are becoming more popular in CPES for certain tasks due to…

Multiagent Systems · Computer Science 2024-03-08 Sanja Stark , Emilie Frost , Marvin Nebel-Wenner

Glyph-based visualization is one of the main techniques for visualizing complex multivariate data. With small glyphs, data variables are typically encoded with relatively low visual and perceptual precision. Glyph designers have to…

Human-Computer Interaction · Computer Science 2024-12-18 Hong-Po Hsieh , Amy Zavatsky , Min Chen

Compact semiconductor device models are essential for efficiently designing and analyzing large circuits. However, traditional compact model development requires a large amount of manual effort and can span many years. Moreover, inclusion…

Machine Learning · Computer Science 2020-01-07 K. Aadithya , P. Kuberry , B. Paskaleva , P. Bochev , K. Leeson , A. Mar , T. Mei , E. Keiter

Mobile Edge Computing (MEC) enables rich services in close proximity to the end users to provide high quality of experience (QoE) and contributes to energy conservation compared with local computing, but results in increased communication…

Networking and Internet Architecture · Computer Science 2020-03-31 Mingxiong Zhao , Jun-Jie Yu , Wen-Tao Li , Di Liu , Shaowen Yao , Wei Feng , Changyang She , Tony Q. S. Quek

Algorithm parallelization to leverage multi-core platforms for improving the efficiency of Electronic Design Automation~(EDA) tools plays a significant role in enhancing the scalability of Integrated Circuit (IC) designs. Logic optimization…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-04-23 Ye Cai , Zonglin Yang , Liwei Ni , Junfeng Liu , Biwei Xie , Xingquan Li

As machine learning permeates more industries and models become more expensive and time consuming to train, the need for efficient automated hyperparameter optimization (HPO) has never been more pressing. Multi-step planning based…

Machine Learning · Computer Science 2022-11-18 Lucio M. Dery , Abram L. Friesen , Nando De Freitas , Marc'Aurelio Ranzato , Yutian Chen

We study efficiency as a first-class objective in Neural Combinatorial Optimization (NCO) and present ECO, an efficient learning framework that combines batched preference optimization with a Mamba backbone. Instead of tightly interleaving…

Machine Learning · Computer Science 2026-04-29 Zhenxing Xu , Zeyuan Ma , Weidong Bao , Yan Zheng , Ji Wang , Zhiguang Cao

With the proliferation of edge AI applications, satisfying user quality of experience (QoE) requirements, such as model inference latency, has become a first class objective, as these models operate in resource constrained settings and…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-12-15 Jianli Jin , Ziyang Lin , Qianli Dong , Yi Chen , Jayanth Srinivasa , Myungjin Lee , Zhaowei Tan , Fan Lai

Porous flow-through electrodes are used as the core reactive component across electrochemical technologies. Controlling the fluid flow, species transport, and reactive environment is critical to attaining high performance. However,…