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The goal of this work is to study the optimal controls for the COVID-19 epidemic in Brazil. We consider an age-structured SEIRQ model with quarantine compartment, where the controls are the quarantine entrance parameters. We then compare…

Populations and Evolution · Quantitative Biology 2020-05-21 João A. M. Gondim , Larissa Machado

The paper addresses the question of lives versus livelihood in an SIRD model augmented with a macroeconomic structure. The constraints on the availability of health facilities - both infrastructure and health workers determine the…

Dynamical Systems · Mathematics 2021-09-07 Gopal K. Basak , Chandramauli Chakraborty , Pranab Kumar Das

Optimizing the impact on the economy of control strategies aiming at containing the spread of COVID-19 is a critical challenge. We use daily new case counts of COVID-19 patients reported by local health administrations from different…

Populations and Evolution · Quantitative Biology 2021-03-12 Afroza Shirin , Yen Ting Lin , Francesco Sorrentino

In this work, we provide a general mathematical formalism to study the optimal control of an epidemic, such as the COVID-19 pandemic, via incentives to lockdown and testing. In particular, we model the interplay between the government and…

Populations and Evolution · Quantitative Biology 2022-04-14 Emma Hubert , Thibaut Mastrolia , Dylan Possamaï , Xavier Warin

We introduce a policy model coupled with the susceptible-infected-recovered (SIR) epidemic model to study interactions between policy-making and the dynamics of epidemics. We consider both single-region policies, as well as game-theoretic…

Optimization and Control · Mathematics 2024-08-06 Xia Li , Andrea L. Bertozzi , P. Jeffrey Brantingham , Yevgeniy Vorobeychik

The COVID-19 pandemic constitutes one of the largest threats in recent decades to the health and economic welfare of populations globally. In this paper, we analyze different types of policy measures designed to fight the spread of the…

General Economics · Economics 2020-11-03 Philipp Bach , Victor Chernozhukov , Martin Spindler

Social distancing strategies have been adopted by governments to manage the COVID-19 pandemic, since the first outbreak began. However, further epidemic waves keep out the return of economic and social activities to their standard levels of…

Optimization and Control · Mathematics 2021-06-07 J. E. Sereno , A. D' Jorge , A. Ferramosca , E. A. Hernandez-Vargas , A. H. Gonzalez

In the framework of homogeneous susceptible-infected-recovered (SIR) models, we use a control theory approach to identify optimal pandemic mitigation strategies. We derive rather general conditions for reaching herd immunity while…

Populations and Evolution · Quantitative Biology 2021-07-05 Prakhar Godara , Stephan Herminghaus , Knut M. Heidemann

The SIQR model is reformulated where compartments for infected and quarantined are redefined so as to be appropriate to COVID-19, and exact properties of the model are presented. It is shown that the maximum number of infected at large…

Physics and Society · Physics 2020-12-30 Takashi Odagaki

Pandemics involve the high transmission of a disease that impacts global and local health and economic patterns. The impact of a pandemic can be minimized by enforcing certain restrictions on a community. However, while minimizing infection…

Artificial Intelligence · Computer Science 2024-02-13 Ishir Rao

Optimal control problems reflecting the finding of effective quarantine strategies are considered for two control SEIR~type models describing the spread of the COVID-19 virus in the human population. The properties of the corresponding…

Optimization and Control · Mathematics 2020-11-30 Ellina Grigorieva , Evgenii Khailov , Andrei Korobeinikov

We apply optimal control theory to a generalized SEIR-type model. The proposed system has three controls, representing social distancing, preventive means, and treatment measures to combat the spread of the COVID-19 pandemic. We analyze…

Optimization and Control · Mathematics 2021-12-10 Mohamed Abdelaziz Zaitri , Mohand Ouamer Bibi , Delfim F. M. Torres

We study an optimal control problem where the objective is to find the best vaccine allocation during an epidemic outbreak. The epidemic dynamics is described by an age-structured SIR model with nonlocal interactions. Both the infection and…

Optimization and Control · Mathematics 2026-05-19 Luís Almeida , Romain Ducasse , Elisa Paparelli

We propose and study a compartmental model for epidemiology with human behavioral effects. Specifically, our model incorporates governmental prevention measures aimed at lowering the disease infection rate, but we split the population into…

Systems and Control · Electrical Eng. & Systems 2026-02-16 Chloe Ngo , Christian Parkinson , Weinan Wang

During the COVID-19 pandemic of 2019/2020, authorities have used temporary ad-hoc policy measures, such as lockdowns and mass quarantines, to slow its transmission. However, the consequences of widespread use of these unprecedented measures…

Strategies adopted globally to mitigate the threat of COVID-19 have primarily involved lockdown measures with substantial economic and social costs with varying degrees of success. Morbidity patterns of COVID-19 variants have a strong…

Populations and Evolution · Quantitative Biology 2022-01-19 Fatima-Zahra Jaouimaa , Daniel Dempsey , Suzanne van Osch , Stephen Kinsella , Kevin Burke , Jason Wyse , James Sweeney

The novel coronavirus SARS-CoV-2 and resulting COVID-19 disease have had an unprecedented spread and continue to cause an increasing number of fatalities worldwide. While vaccines are still under development, social distancing, extensive…

Populations and Evolution · Quantitative Biology 2020-07-02 Calvin Tsay , Fernando Lejarza , Mark A. Stadtherr , Michael Baldea

Lockdown procedures have been proven successful in mitigating the spread of the viruses in this COVID-19 pandemic, but they also have devastating impact on the economy. We use a modified Susceptible-Infectious-Recovered-Deceased model with…

Physics and Society · Physics 2021-02-24 Sung-Po Chao

Cost-effectiveness analysis is a mode of determining both the cost and economic health outcomes of one or more control interventions. In this work, we have formulated a non-autonomous nonlinear deterministic model to study the control of…

As the world fights to contain and control the spread of the Novel Coronavirus, countries are imposing severe measures from restrictions on travel and social gatherings to complete lockdowns. Lockdowns, though effective in controlling the…

Physics and Society · Physics 2020-05-19 Saket Saurabh , Ayush Trivedi , Nithilaksh P. Lokesh , Bhagyashree Gaikwad