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Proton therapy provides superior dose conformity compared with photon radiotherapy, concentrating radiation within the tumor while sparing adjacent healthy tissue. This advantage has been most effectively realized for static tumors in…

Medical Physics · Physics 2025-10-09 Vivek Maradia , Nick Yue , Adam Molzahn , Jingqian Wang , Mark Pankuch , Serdar Charyyev , Billy W. Loo

High energy ion beams (> MeV) generated by intense laser pulses promise to be viable alternatives to conventional ion beam sources due to their unique properties such as high charge, low emittance, compactness and ease of beam delivery.…

In the last ten years the use of proton beams in radiation therapy has become a clinical tool for treatment of deep-seated tumours. LIBO is a RF compact and low cost proton linear accelerator (SCL type) for hadrontherapy. It is conceived by…

Accelerator Physics · Physics 2009-09-29 Paolo Berra

In the effort of achieving high-energetic ion beams from the interaction of ultrashort laser pulses with a plasma, volumetric acceleration mechanisms beyond Target Normal Sheath Acceleration have gained attention. A relativisticly intense…

Despite all the advances achieved in the field of tumor-biology research, in most cases conventional therapies including chemotherapy are still the leading choices. The main disadvantage of these treatments, in addition to the low…

Tissues and Organs · Quantitative Biology 2024-01-25 Paola Sanchez-Moreno , Juan Luis Ortega-Vinuesa , Jose Manuel Peula-Garcia , Juan Antonio Marchal , Houria Boulaiz

The identification of pre-acceleration mechanisms for cosmic ray ions in supernova remnant shocks is an important problem in astrophysics. Recent particle-in-cell (PIC) shock simulations have shown that inclusion of the full electron…

Astrophysics · Physics 2009-11-10 R. E. Lee , S. C. Chapman , R. O. Dendy

The future accelerator facility for beams of ions and antiprotons at Darmstadt will provide antiproton beams of intensities that are two orders of magnitude higher than currently available. Within the foreseen scheme, antiprotons can be…

Nuclear Experiment · Physics 2015-06-26 E. Widmann

Ion acceleration by using a laser pulse irradiating a disk target which includes hydrogen and carbon is examined using three-dimensional particle-in-cell simulations. It is shown that over $200$ MeV protons can be generated by using a…

Plasma Physics · Physics 2015-06-18 Toshimasa Morita

We examine ion acceleration by irradiating a hundred TW laser pulse on a double-layer target. It is shown analytically and by three-dimensional particle-in-cell simulations that higher energy protons are obtained by using material with a…

Plasma Physics · Physics 2011-03-03 Toshimasa Morita , Sergei V. Bulanov , Timur Zh. Esirkepov , James Koga , Masaki Kando

A numerical study on ion acceleration in electrostatic shock waves is presented, with the aim of determining the best plasma configuration to achieve quasi-monoenergetic ion beams in laser-driven systems. It was recently shown that tailored…

Plasma Physics · Physics 2018-03-14 E. Boella , F. Fiúza , A. Stockem Novo , R. Fonseca , L. O. Silva

The use of terahertz (THz) and optical radiation for electron acceleration and manipulation of electron bunches has progressed over the last decade to a level where practical devices for THz guns, THz and optical acceleration modules and a…

Accelerator Physics · Physics 2026-04-08 Franz X. Kärtner

The dynamics of the acceleration of ultrathin foil targets by the radiation pressure of superintense, circularly polarized laser pulses is investigated by analytical modeling and particle-in-cell simulations. By addressing self-induced…

Plasma Physics · Physics 2010-10-12 Andrea Macchi , Silvia Veghini , Francesco Pegoraro

For the successful generation of ion-beam-driven high energy density matter and heavy ion fusion energy, intense ion beams must be transported and focused onto a target with small spot size. One of the successful approaches to achieve this…

Magnetic Vortex Acceleration (MVA) from near critical density targets is one of the promising schemes of laser-driven ion acceleration. 3D particle-in-cell simulations are used to explore a more extensive laser-target parameter space than…

Purpose of review: Artificial intelligence (AI) has become popular in medical applications, specifically as a clinical support tool for computer-aided diagnosis. These tools are typically employed on medical data (i.e., image, molecular…

Machine Learning · Computer Science 2022-06-08 Ahmad Chaddad , Yousef Katib , Lama Hassan

We propose a hybrid laser-driven ion acceleration scheme using a combination target of a solid foil and a density-tailored background plasma. In the first stage, a sub-relativistic proton beam can be generated by the radiation pressure…

Plasma Physics · Physics 2018-06-29 M. Liu , S. M. Weng , H. C. Wang , M. Chen , Q. Zhao , Z. M. Sheng , M. Q. He , Y. T. Li , J. Zhang

The ion beam bunching in a cascaded target normal sheath acceleration is investigated by theoretical analysis and particle-in-cell simulations. It is found that a proton beam can be accelerated and bunched simultaneously by injecting it…

Plasma Physics · Physics 2018-09-12 H. C. Wang , S. M. Weng , M. Liu , M. Chen , M. Q. He , Q. Zhao , M. Murakami , Z. M. Sheng

The interaction of a high-intensity ultrashort laser pulse with a few microns-thick hydrocarbon target is known to accelerate protons/ions to multi-MeV, on the rear side of the target, via the mechanism of target normal sheath acceleration.…

Plasma Physics · Physics 2023-11-13 Imran Khan , Vikrant Saxena

While laser-plasma accelerators have demonstrated a strong potential in the acceleration of electrons up to giga-electronvolt energies, few experimental tools for studying the acceleration physics have been developed. In this paper, we…

Plasma Physics · Physics 2013-09-27 C. Thaury , K. Ta Phuoc , S. Corde , P. Brijesh , G. Lambert , S. P. D. Mangles , M. S. Bloom , S. Kneip , V. Malka

In proton therapy, depth scanning of the irradiated object is performed by changing the Output Energy (OE) of the accelerated beam. In pulsed linear accelerators, adjustment of the OE is usually by changing the amplitude and/or phase of the…

Accelerator Physics · Physics 2023-10-09 L. Yu. Ovchinnikova , A. P. Durkin , A. S. Kurilik , V. V. Paramonov