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Synthetic polymeric materials underpin fundamental technologies in the energy, electronics, consumer goods, and medical sectors, yet their development still suffers from prolonged design timelines. Although polymer informatics tools have…

Computational Engineering, Finance, and Science · Computer Science 2025-06-12 Ayush Jain , Rampi Ramprasad

One of the grand challenges of utilizing machine learning for the discovery of innovative new polymers lies in the difficulty of accurately representing the complex structures of polymeric materials. Although a wide array of hand-designed…

Materials Science · Physics 2022-05-30 Evan R. Antoniuk , Peggy Li , Bhavya Kailkhura , Anna M. Hiszpanski

Polymer materials have the characteristic feature that they are multiscale systems by definition. Already the description of a single molecules involves a multitude of different scales, and cooperative processes in polymer assemblies are…

Chemical Physics · Physics 2022-12-20 Friederike Schmid

Synthetic polymers are versatile and widely used materials. Similar to small organic molecules, a large chemical space of such materials is hypothetically accessible. Computational property prediction and virtual screening can accelerate…

Machine Learning · Computer Science 2022-10-13 Matteo Aldeghi , Connor W. Coley

Designing polymers for targeted applications and accurately predicting their properties is a key challenge in materials science owing to the vast and complex polymer chemical space. While molecular language models have proven effective in…

Soft Condensed Matter · Physics 2025-10-20 Anagha Savit , Harikrishna Sahu , Shivank Shukla , Wei Xiong , Rampi Ramprasad

Polymers are a vital part of everyday life. Their chemical universe is so large that it presents unprecedented opportunities as well as significant challenges to identify suitable application-specific candidates. We present a complete…

Materials Science · Physics 2023-07-20 Christopher Kuenneth , Rampi Ramprasad

We introduce PolyRecommender, a multimodal discovery framework that integrates chemical language representations from PolyBERT with molecular graph-based representations from a graph encoder. The system first retrieves candidate polymers…

Machine Learning · Computer Science 2025-11-04 Xin Wang , Yunhao Xiao , Rui Qiao

From the relative scarcity of training data to the lack of standardized benchmarks, the development of foundation models for polymers face significant and multi-faceted challenges. At the core, many of these issues are tied directly to the…

Polymers, macromolecules formed from covalently bonded monomers, underpin countless technologies and are indispensable to modern life. While deep learning is advancing polymer science, existing methods typically represent the whole polymer…

Machine Learning · Computer Science 2025-10-21 Fanmeng Wang , Shan Mei , Wentao Guo , Hongshuai Wang , Qi Ou , Zhifeng Gao , Hongteng Xu

Polymers are diverse and versatile materials that have met a wide range of material application demands. They come in several flavors and architectures, e.g., homopolymers, copolymers, polymer blends, and polymers with additives. Searching…

Soft Condensed Matter · Physics 2024-11-05 Shivank S. Shukla , Christopher Kuenneth , Rampi Ramprasad

The problem of molecular generation has received significant attention recently. Existing methods are typically based on deep neural networks and require training on large datasets with tens of thousands of samples. In practice, however,…

Machine Learning · Computer Science 2022-03-16 Minghao Guo , Veronika Thost , Beichen Li , Payel Das , Jie Chen , Wojciech Matusik

Recent research in molecular discovery has primarily been devoted to small, drug-like molecules, leaving many similarly important applications in material design without adequate technology. These applications often rely on more complex…

Copolymers are highly versatile materials with a vast range of possible chemical compositions. By using computational methods for property prediction, the design of copolymers can be accelerated, allowing for the prioritization of…

Materials Science · Physics 2025-09-16 Elaheh Kazemi-Khasragh , Rocío Mercado , Carlos Gonzalez , Maciej Haranczyk

Accurate prediction of polymer properties is essential for materials design, but remains challenging due to data scarcity, diverse polymer representations, and the lack of systematic evaluation across modelling choices. Here, we present…

Soft Condensed Matter · Physics 2026-03-17 Gaopeng Ren , Yijie Yang , Jiajun Zhou , Kim E. Jelfs

Polymers are large macromolecules composed of repeating structural units known as monomers and are widely applied in fields such as energy storage, construction, medicine, and aerospace. However, existing graph neural network methods,…

Machine Learning · Computer Science 2026-01-06 Yihan Zhu , Gang Liu , Eric Inae , Tengfei Luo , Meng Jiang

There has been rapidly growing demand of polymeric materials coming from different aspects of modern life because of the highly diverse physical and chemical properties of polymers. Polymer informatics is an interdisciplinary research field…

Soft Condensed Matter · Physics 2020-10-16 Stephen Wu , Hironao Yamada , Yoshihiro Hayashi , Massimiliano Zamengo , Ryo Yoshida

Polymers are candidate materials for a wide range of sustainability applications such as carbon capture and energy storage. However, computational polymer discovery lacks automated analysis of reaction pathways and stability assessment…

Chemical Physics · Physics 2023-10-18 Brenda S. Ferrari , Matteo Manica , Ronaldo Giro , Teodoro Laino , Mathias B. Steiner

Traditional machine learning has advanced polymer discovery, yet direct generation of chemically valid and synthesizable polymers without exhaustive enumeration remains a challenge. Here we present polyT5, an encoder-decoder chemical…

Materials Science · Physics 2025-10-22 Harikrishna Sahu , Wei Xiong , Anagha Savit , Shivank S Shukla , Rampi Ramprasad

While machine learning has transformed polymer design by enabling rapid property prediction and candidate generation, translating these designs into experimentally realizable materials remains a critical challenge. Traditionally, the…

Soft Condensed Matter · Physics 2025-12-08 Sakshi Agarwal , Wei Xiong , Rampi Ramprasad

Can large language models predict physical and mechanical polymer properties simply by reading unstructured scientific prose? Polymer performance is rarely determined by chemical structure alone; identical nominal polymers can exhibit…

Machine Learning · Computer Science 2026-05-12 Yuchu Liu , Rui Zhu , Jingwei Xiong , Haixu Tang
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