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Given experimental data, one of the main objectives of biological modeling is to construct a model which best represents the real world phenomena. In some cases, there could be multiple distinct models exhibiting the exact same dynamics,…

Combinatorics · Mathematics 2024-12-03 Cashous Bortner , John Gilliana , Dev Patel , Zaia Tamras

Nonlinear dynamical systems are complex and typically only simple systems can be analytically studied. In applications, these systems are usually defined with a set of tunable parameters and as the parameters are varied the system response…

Dynamical Systems · Mathematics 2025-05-05 Max M. Chumley , Firas A. Khasawneh

Growing experimental evidence shows that proteins follow one or a few distinct paths when folding. We propose in this paper a procedure to parametrize these observed pathways, and from this parametrization construct effective Hamiltonians…

Condensed Matter · Physics 2007-05-23 Paul G. Dommersnes , Alex Hansen , Mogens H. Jensen , Kim Sneppen

We present a machine learning approach that leverages persistent homology to classify bacterial flagellar motors into two functional states: rotated and stalled. By embedding protein structural data into a topological framework, we extract…

Biomolecules · Quantitative Biology 2025-12-19 Zakaria Lamine , Abdelatif Hafid , Mohamed Rahouti

We present an algorithm to express Wilson lines that are defined on piecewise linear paths in function of their individual segments, reducing the number of diagrams needed to be calculated. The important step lies in the observation that…

High Energy Physics - Phenomenology · Physics 2016-03-23 Frederik F. Van der Veken

Persistent homology is a widely-used tool in topological data analysis (TDA) for understanding the underlying shape of complex data. By constructing a filtration of simplicial complexes from data points, it captures topological features…

Algebraic Topology · Mathematics 2025-10-23 Aleksei Luchinsky , Umar Islambekov

We develop a method for analyzing spatial and spatiotemporal anomalies in geospatial data using topological data analysis (TDA). To do this, we use persistent homology (PH), which allows one to algorithmically detect geometric voids in a…

Physics and Society · Physics 2022-03-01 Abigail Hickok , Deanna Needell , Mason A. Porter

How do LLMs learn in-context? Is it by pattern-matching recent tokens, or by inferring latent structure? We probe this question using a toy graph random-walk across two competing graph structures. This task's answer is, in principle,…

Artificial Intelligence · Computer Science 2026-05-12 Katharine Kowalyshyn , Timothy Duggan , Daniel Little , Michael C Hughes

Level-sensitive latches are widely used in high- performance designs. For such circuits efficient statistical timing analysis algorithms are needed to take increasing process vari- ations into account. But existing methods solving this…

Other Computer Science · Computer Science 2017-05-16 Bing Li , Ning Chen , Ulf Schlichtmann

The aim of this article is to provide a simple sampling procedure to reconstruct any monotone path from its signature. For every N, we sample a lattice path of N steps with weights given by the coefficient of the corresponding word in the…

Probability · Mathematics 2016-12-15 Jiawei Chang , Nick Duffield , Hao Ni , Weijun Xu

Anomaly detection in continuous-time dynamic graphs is an emerging field yet under-explored in the context of learning algorithms. In this paper, we pioneer structured analyses of link-level anomalies and graph representation learning for…

Machine Learning · Computer Science 2024-10-01 Tim Poštuvan , Claas Grohnfeldt , Michele Russo , Giulio Lovisotto

Persistent Homology (PH) is a useful tool to study the underlying structure of a data set. Persistence Diagrams (PDs), which are 2D multisets of points, are a concise summary of the information found by studying the PH of a data set.…

Computational Geometry · Computer Science 2020-11-24 Megan Johnson , Jae-Hun Jung

Persistent homology (PH) has been widely applied to graph data to extract topological features. However, little attention has been paid to how different distance functions on a graph affect the resulting persistence barcodes and their…

Algebraic Topology · Mathematics 2026-02-17 Eunwoo Heo , Byeongchan Choi , Jae-Hun Jung

In this paper we demonstrate the use of multivariate topological algorithms to analyse and interpret Lattice Quantum Chromodynamics (QCD) data. Lattice QCD is a long established field of theoretical physics research in the pursuit of…

High Energy Physics - Lattice · Physics 2020-08-10 Dean P. Thomas , Rita Borgo , Robert S. Laramee , Simon J. Hands

We present a unified pipeline for univariate time series classification via complex networks and persistent homology. A time series is mapped to a graph through one of five constructions across three families (visibility (natural and…

Algebraic Topology · Mathematics 2026-05-05 İsmail Güzel

Applying a ML approach to the temporal variability of the Spike protein sequence enables us to identify, classify and track emerging virus variants. Our analysis is unbiased, in the sense that it does not require any prior knowledge of the…

Multiplexed imaging allows multiple cell types to be simultaneously visualised in a single tissue sample, generating unprecedented amounts of spatially-resolved, biological data. In topological data analysis, persistent homology provides…

Quantitative Methods · Quantitative Biology 2025-05-06 Maria Torras-Pérez , Iris H. R. Yoon , Praveen Weeratunga , Ling-Pei Ho , Helen M. Byrne , Ulrike Tillmann , Heather A. Harrington

Topological data analysis is becoming increasingly relevant to support the analysis of unstructured data sets. A common assumption in data analysis is that the data set is a sample---not necessarily a uniform one---of some high-dimensional…

Algebraic Topology · Mathematics 2021-01-20 Bastian Rieck , Markus Banagl , Filip Sadlo , Heike Leitte

We present a representation learning algorithm that learns a low-dimensional latent dynamical system from high-dimensional \textit{sequential} raw data, e.g., video. The framework builds upon recent advances in amortized inference methods…

Machine Learning · Computer Science 2020-01-29 Jung-Su Ha , Young-Jin Park , Hyeok-Joo Chae , Soon-Seo Park , Han-Lim Choi

Cytometry experiments yield high-dimensional point cloud data that is difficult to interpret manually. Boolean gating techniques coupled with comparisons of relative abundances of cellular subsets is the current standard for cytometry data…

Quantitative Methods · Quantitative Biology 2022-05-04 Soham Mukherjee , Darren Wethington , Tamal K. Dey , Jayajit Das
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