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Protein subcellular localization is an important factor in normal cellular processes and disease. While many protein localization resources treat it as static, protein localization is dynamic and heavily influenced by biological context.…

Molecular Networks · Quantitative Biology 2022-12-13 Chris S. Magnano , Anthony Gitter

Persistent Homology (PH) is a fundamental tool in computational topology, designed to uncover the intrinsic geometric and topological features of data across multiple scales. Originating within the broader framework of Topological Data…

Algebraic Topology · Mathematics 2025-05-13 Aurelie Jodelle Kemme , Collins Amburo Agyingi

One of the primary areas of interest in applied algebraic topology is persistent homology, and, more specifically, the persistence diagram. Persistence diagrams have also become objects of interest in topological data analysis. However,…

Methodology · Statistics 2018-04-06 Eric Berry , Yen-Chi Chen , Jessi Cisewski-Kehe , Brittany Terese Fasy

As the field of Topological Data Analysis continues to show success in theory and in applications, there has been increasing interest in using tools from this field with methods for machine learning. Using persistent homology, specifically…

Computational Geometry · Computer Science 2020-02-26 Sarah Tymochko , Elizabeth Munch , Firas A. Khasawneh

Topological data analysis uses tools from topology -- the mathematical area that studies shapes -- to create representations of data. In particular, in persistent homology, one studies one-parameter families of spaces associated with data,…

Machine Learning · Computer Science 2020-12-01 Guido Montúfar , Nina Otter , Yuguang Wang

Over the past two decades, there has been a tremendous increase in the growth of representation learning methods for graphs, with numerous applications across various fields, including bioinformatics, chemistry, and the social sciences.…

Machine Learning · Computer Science 2023-12-21 Abdulkadir Celikkanat , Nikolaos Nakis , Morten Mørup

We provide a process on the space of coalescing cadlag stable paths and show convergence in the appropriate topology for coalescing stable random walks on the integer lattice.

Probability · Mathematics 2019-05-21 Thomas Mountford , Krishnamurthi Ravishankar , Glauco Valle

In this work, Transition Probability Matrix (TPM) is proposed as a new method for extracting the features of nodes in the graph. The proposed method uses random walks to capture the connectivity structure of a node's close neighborhood. The…

Machine Learning · Computer Science 2023-03-07 Sarmad N. Mohammed , Semra Gündüç

Stratified digraphs are popular models for feedforward neural networks. However, computation of their path homologies has been limited to low dimensions due to high computational complexity. A recursive algorithm is proposed to compute…

Computational Geometry · Computer Science 2024-12-12 Zhengtong Zhu , Zhiyi Chi

Two-dimensional (2D) particle systems, such as magnetic skyrmions, exhibit topological phase transitions between unique 2D phases. However, a simple and computationally efficient methodology to capture lattice configurational properties and…

We introduce an epidemic spreading model on a network using concepts from percolation theory. The model is motivated by discussing the standard SIR model, with extensions to describe effects of lockdowns within a population. The underlying…

Physics and Society · Physics 2020-08-26 Fabrizio Croccolo , H. Eduardo Roman

We introduce a new type of lattice path, called brick-wall lattice path, and we derive a formula which counts the number of paths on these lattices imposing certain restrictions on the Cartesian plane. Connections to the Fibonacci sequence,…

Combinatorics · Mathematics 2018-04-17 Leonard Daus , Valeriu Beiu , Simon Cowell , Philippe Poulin

We introduce the persistence heatmap, a parametrized summary based on representative cycles in persistence diagrams, designed to enhance stability and explainability in topological data analysis. Algorithms to compute persistence diagrams…

Algebraic Topology · Mathematics 2025-10-15 Himanshu Yadav , Alexander Wagner , Peter Bubenik

Unified graph representation learning aims to generate node embeddings, which can be applied to multiple downstream applications of graph analytics. However, existing studies based on graph neural networks and language models either suffer…

Computation and Language · Computer Science 2025-08-05 Wenbo Shang , Xuliang Zhu , Xin Huang

Detection of curvilinear structures in images has long been of interest. One of the most challenging aspects of this problem is inferring the graph representation of the curvilinear network. Most existing delineation approaches first…

Computer Vision and Pattern Recognition · Computer Science 2019-05-13 Agata Mosinska , Mateusz Kozinski , Pascal Fua

As the major target of many vaccines and neutralizing antibodies against SARS-CoV-2, the spike (S) protein is observed to mutate over time. In this paper, we present statistical approaches to tackle some challenges associated with the…

Applications · Statistics 2021-02-02 Shiyu He , Samuel W. K. Wong

We start with a simple introduction to topological data analysis where the most popular tool is called a persistent diagram. Briefly, a persistent diagram is a multiset of points in the plane describing the persistence of topological…

Statistics Theory · Mathematics 2017-06-28 Christophe Biscio , Jesper Møller

Architected materials possessing physico-chemical properties adaptable to disparate environmental conditions embody a disruptive new domain of materials science. Fueled by advances in digital design and fabrication, materials shaped into…

Materials Science · Physics 2023-09-25 Dominik Dold , Derek Aranguren van Egmond

In topological data analysis, persistent homology characterizes robust topological features in data and it has a summary representation, called a persistence diagram. Statistical research for persistence diagrams have been actively…

Algebraic Topology · Mathematics 2018-10-29 Genki Kusano

Especially in lattice structured populations, homogeneous mixing represents an inadequate assumption. Various improvements upon the ordinary pair approximation based on a number of assumptions concerning the higher-order correlations have…

Populations and Evolution · Quantitative Biology 2007-05-23 Thomas Petermann , Paolo De Los Rios
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