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Radiation therapy outcomes are decided by two key parameters, dose and timing, whose best values vary substantially across patients. This variability is especially critical in the treatment of brain cancer, where fractionated or staged…

Medical Physics · Physics 2025-06-24 Hao Peng , Steve Jiang , Robert Timmerman

We consider code optimization and angle-Doppler imaging for slow-time code division multiplexing (ST-CDM) linear frequency-modulated continuous-wave (LFMCW) multiple-input multiple-output (MIMO) radar systems. We optimize the slow-time code…

Signal Processing · Electrical Eng. & Systems 2023-06-16 Xiaolei Shang , Yuanbo Cheng

Spectral Deferred Correction (SDC) is an iterative method for the numerical solution of ordinary differential equations. It works by refining the numerical solution for an initial value problem by approximately solving differential…

Numerical Analysis · Mathematics 2025-09-09 Thomas Saupe , Sebastian Götschel , Thibaut Lunet , Daniel Ruprecht , Robert Speck

Video dubbing aims to translate original speech in visual media programs from the source language to the target language, relying on neural machine translation and text-to-speech technologies. Due to varying information densities across…

Sound · Computer Science 2025-08-13 Chaoqun Cui , Liangbin Huang , Shijing Wang , Zhe Tong , Zhaolong Huang , Xiao Zeng , Xiaofeng Liu

Radiotherapy treatment planning is a challenging large-scale optimization problem plagued by uncertainty. Following the robust optimization methodology, we propose a novel, spatially based uncertainty set for robust modeling of radiotherapy…

Optimization and Control · Mathematics 2024-05-28 Noam Goldberg , Mark P. Langer , Shimrit Shtern

Purpose: The FLASH effect, which reduces the radiosensitivity of healthy tissue while maintaining tumor control at high dose rates, has shown potential for improving radiation therapy. Conformal FLASH proton therapy involves advanced…

Medical Physics · Physics 2023-04-13 Sylvain Deffet , Edmond Sterpin

This paper proposes a unified framework for the global optimization of a continuous function in a bounded rectangular domain. Specifically, we show that: (1) under the optimal strategy for a two-armed decision model, the sample mean…

Optimization and Control · Mathematics 2025-11-11 Xiaohong Chen , Zengjing Chen , Wayne Yuan Gao , Xiaodong Yan , Guodong Zhang

Deep learning methods are actively used for brain lesion segmentation. One of the most popular models is DeepMedic, which was developed for segmentation of relatively large lesions like glioma and ischemic stroke. In our work, we consider…

Computer Vision and Pattern Recognition · Computer Science 2018-08-02 Egor Krivov , Valery Kostjuchenko , Alexandra Dalechina , Boris Shirokikh , Gleb karchuk , Alexander Denisenko , Andrey Golanov , Mikhail Belyaev

This paper proposes SplitSGD, a new dynamic learning rate schedule for stochastic optimization. This method decreases the learning rate for better adaptation to the local geometry of the objective function whenever a stationary phase is…

Machine Learning · Statistics 2024-02-20 Matteo Sordello , Niccolò Dalmasso , Hangfeng He , Weijie Su

This paper presents a multi-objective stochastic optimization method for tuning of the controller parameters of Refrigeration Systems based on Vapour Compression. Stochastic Multi Parameter Divergence Optimization (SMDO) algorithm is…

Systems and Control · Computer Science 2018-06-05 Abdullah Ates , Jie Yuan , Sina Dehghan , Yang Zhao , Celaleddin Yeroglu , YangQuan Chen

3D computer-assisted corrective osteotomy has become the state-of-the-art for surgical treatment of complex bone deformities. Despite available technologies, the automatic generation of clinically acceptable, ready-to-use preoperative…

Modern synchrotron light source storage rings, such as the Swiss Light Source upgrade (SLS 2.0), use multi-bend achromats in their arc segments to achieve unprecedented brilliance. This performance comes at the cost of increased focusing…

Accelerator Physics · Physics 2021-01-27 Marija Kranjcevic , Bernard Riemann , Andreas Adelmann , Andreas Streun

Purpose: Various dose calculation algorithms are available for radiation therapy for cancer patients. However, these algorithms are faced with the tradeoff between efficiency and accuracy. The fast algorithms are generally less accurate,…

Medical Physics · Physics 2020-07-01 Yixun Xing , Dan Nguyen , Weiguo Lu , Ming Yang , Steve Jiang

Background. Designing trials to reduce treatment duration is important in several therapeutic areas, including TB and antibiotics. We recently proposed a new randomised trial design to overcome some of the limitations of standard two-arm…

Iterative Refinement (IR) is a classical computing technique for obtaining highly precise solutions to linear systems of equations, as well as linear optimization problems. In this paper, motivated by the limited precision of quantum…

Optimization and Control · Mathematics 2023-12-19 Mohammadhossein Mohammadisiahroudi , Brandon Augustino , Pouya Sampourmahani , Tamás Terlaky

We present DDTO--deferred-decision trajectory optimization--a framework for trajectory generation with resilience to unmodeled uncertainties and contingencies. The key idea is to ensure that a collection of candidate targets is reachable…

Optimization and Control · Mathematics 2025-02-11 Purnanand Elango , Selahattin Burak Sarsilmaz , Behcet Acikmese

Purpose: To evaluate automated multicriteria optimization (MCO)-- designed for intensity modulated radiation therapy (IMRT), but invoked with limited segmentation -- to efficiently produce high quality 3D conformal treatment (3D-CRT) plans.…

Medical Physics · Physics 2014-02-03 Fazal Khan , David Craft

This paper addresses the problem of single snapshot Direction-of-Arrival (DOA) estimation, which is of great importance in a wide-range of applications including automotive radar. A popular approach to achieving high angular resolution when…

Signal Processing · Electrical Eng. & Systems 2024-03-12 Yinyan Bu , Robin Rajamäki , Anand Dabak , Rajan Narasimha , Anil Mani , Piya Pal

Beam orientation optimization (BOO) is a key component in the process of IMRT treatment planning. It determines to what degree one can achieve a good treatment plan quality in the subsequent plan optimization process. In this paper, we have…

Medical Physics · Physics 2015-05-27 Xun Jia , Chunhua Men , Yifei Lou , Steve B. Jiang

Sequential model-based optimization (SMBO) approaches are algorithms for solving problems that require computationally or otherwise expensive function evaluations. The key design principle of SMBO is a substitution of the true objective…

Neural and Evolutionary Computing · Computer Science 2020-04-01 Jakob Bossek , Carola Doerr , Pascal Kerschke