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We present an optimization-based approach to radiation treatment planning over time. Our approach formulates treatment planning as an optimal control problem with nonlinear patient health dynamics derived from the standard linear-quadratic…

Medical Physics · Physics 2022-05-17 Anqi Fu , Lei Xing , Stephen Boyd

We conduct a theoretical study of various solution methods for the adaptive fractionation problem. The two messages of this paper are: (i) dynamic programming (DP) is a useful framework for adaptive radiation therapy, particularly adaptive…

Medical Physics · Physics 2012-02-16 Jagdish Ramakrishnan , David Craft , Thomas Bortfeld , John N. Tsitsiklis

We propose an automatic algorithm, named SDI, for the segmentation of skin lesions in dermoscopic images, articulated into three main steps: selection of the image ROI, selection of the segmentation band, and segmentation. We present…

Computer Vision and Pattern Recognition · Computer Science 2017-03-10 Mario Rosario Guarracino , Lucia Maddalena

Intensity Modulated Radiation Therapy is an effective cancer treatment. Models based on the Generalized Equivalent Uniform Dose (gEUD) provide radiation plans with excellent planning target volume coverage and low radiation for organs at…

Background and Objectives: Predicting patient response to treatment and survival in oncology is a prominent way towards precision medicine. To that end, radiomics was proposed as a field of study where images are used instead of invasive…

Image and Video Processing · Electrical Eng. & Systems 2022-03-02 Amine Amyar , Romain Modzelewski , Pierre Vera , Vincent Morard , Su Ruan

Surgical instrument segmentation in robot-assisted surgery (RAS) - especially that using learning-based models - relies on the assumption that training and testing videos are sampled from the same domain. However, it is impractical and…

Computer Vision and Pattern Recognition · Computer Science 2021-03-25 Zixu Zhao , Yueming Jin , Bo Lu , Chi-Fai Ng , Qi Dou , Yun-Hui Liu , Pheng-Ann Heng

Direction-of-Arrival (DOA) estimation in sensor arrays faces limitations under demanding conditions, including low signal-to-noise ratio, single-snapshot scenarios, coherent sources, and unknown source counts. Conventional beamforming…

Signal Processing · Electrical Eng. & Systems 2025-10-14 Xuyao Deng , Yong Dou , Kele Xu

Multi-objective optimization (MOO) has received growing attention in applications that require learning under multiple criteria. However, the existing MOO formulations do not explicitly account for distributional shifts in the data. We…

Machine Learning · Computer Science 2026-05-08 Yufeng Yang , Fangning Zhuo , Ziyi Chen , Heng Huang , Yi Zhou

Over the past two decades, descent methods have received substantial attention within the multiobjective optimization field. Nonetheless, both theoretical analyses and empirical evidence reveal that existing first-order methods for…

Optimization and Control · Mathematics 2024-11-13 Jian Chen , Liping Tang , Xinmin Yang

In the medical images field, semantic segmentation is one of the most important, yet difficult and time-consuming tasks to be performed by physicians. Thanks to the recent advancement in the Deep Learning models regarding Computer Vision,…

Image and Video Processing · Electrical Eng. & Systems 2023-09-21 Leonardo Crespi , Paolo Roncaglioni , Damiano Dei , Ciro Franzese , Nicola Lambri , Daniele Loiacono , Pietro Mancosu , Marta Scorsetti

This paper proposes a Spatially-Augmented Sequence-to-Sequence Neural Diarization (SA-S2SND) framework, which integrates direction-of-arrival (DOA) cues estimated by SRP-DNN into the S2SND backbone. A two-stage training strategy is adopted:…

Audio and Speech Processing · Electrical Eng. & Systems 2026-03-10 Li Li , Ming Cheng , Juan Liu , Ming Li

Radiotherapy is used to treat cancer patients by damaging DNA of tumor cells using ionizing radiation. Photons are the most widely used radiation type for therapy, having been put into use soon after the first discovery of X-rays in 1895.…

Optimization and Control · Mathematics 2019-11-20 Roman Levin , Aleksandr Y. Aravkin , Minsun Kim

Stochastic and (distributionally) robust optimization problems often become computationally challenging as the number of scenarios or data points increases. Scenario reduction is therefore a key technique for improving tractability. We…

Optimization and Control · Mathematics 2026-03-10 Kevin-Martin Aigner , Sebastian Denzler , Frauke Liers , Sebastian Pokutta , Kartikey Sharma

Radiotherapy is the main treatment modality for nasopharynx cancer. Delineation of Gross Target Volume (GTV) from medical images such as CT and MRI images is a prerequisite for radiotherapy. As manual delineation is time-consuming and…

Image and Video Processing · Electrical Eng. & Systems 2021-01-28 Haochen Mei , Wenhui Lei , Ran Gu , Shan Ye , Zhengwentai Sun , Shichuan Zhang , Guotai Wang

Manual annotation of volumetric medical images, such as magnetic resonance imaging (MRI) and computed tomography (CT), is a labor-intensive and time-consuming process. Recent advancements in foundation models for video object segmentation,…

Image and Video Processing · Electrical Eng. & Systems 2025-11-04 Yuwen Chen , Zafer Yildiz , Qihang Li , Yaqian Chen , Haoyu Dong , Hanxue Gu , Nicholas Konz , Maciej A. Mazurowski

We propose an approach based on machine learning to solve two-stage linear adaptive robust optimization (ARO) problems with binary here-and-now variables and polyhedral uncertainty sets. We encode the optimal here-and-now decisions, the…

Machine Learning · Computer Science 2026-04-21 Dimitris Bertsimas , Cheol Woo Kim

Objectives: A new dosimetric variable, dose dropping speed (DDS), was proposed and used to evaluate normal tissue sparing among stereotactic radiosurgery (SRS) plans with different prescription isodose lines. Methods: Forty plans were…

Medical Physics · Physics 2014-08-28 Q. Zhang , D. Zheng , Y. Lei , B. Morgan , J. Driewer , M. Zhang , S. Li , S. Zhou , W. Zhen , R. Thompson , A. Wahl , C. Lin , C. Enke

Radiotherapy-induced normal tissue injury is a clinically important complication, and accurate segmentation of injury regions from medical images could facilitate disease assessment, treatment planning, and longitudinal monitoring. However,…

Computer Vision and Pattern Recognition · Computer Science 2026-04-16 Caiwen Jiang , Lei Zeng , Wei Liu

The long runtime associated with simulating multidisciplinary systems challenges the use of Bayesian optimization for multidisciplinary design optimization (MDO). This is particularly the case if the coupled system is modeled in a…

Computational Engineering, Finance, and Science · Computer Science 2024-08-19 Susanna Baars , Jigar Parekh , Ihar Antonau , Philipp Bekemeyer , Ulrich Römer

In the field of non-invasive medical imaging, radiomic features are utilized to measure tumor characteristics. However, these features can be affected by the techniques used to discretize the images, ultimately impacting the accuracy of…

Image and Video Processing · Electrical Eng. & Systems 2025-11-06 Wenhao Chi , Haiping Liu , Hongqiao Dong , Wenhua Liang , Bo Liu
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