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Computational fluid dynamics (CFD) is increasingly used to study blood flows in patient-specific arteries for understanding certain cardiovascular diseases. The techniques work quite well for relatively simple problems, but need…

Computational Physics · Physics 2018-10-11 Fande Kong , Vitaly Kheyfets , Ender Finol , Xiao-Chuan Cai

Coronary artery bypass grafts (CABG) surgery is an invasive procedure performed to circumvent partial or complete blood flow blockage in coronary artery disease (CAD). In this work, we apply a numerical optimal flow control model to…

Numerical Analysis · Mathematics 2023-08-08 Zakia Zainib , Francesco Ballarin , Stephen Fremes , Piero Triverio , Laura Jiménez-Juan , Gianluigi Rozza

Numerical simulations to evaluate thoracic aortic hemodynamics include a computational fluid dynamic (CFD) approach or fluid-structure interaction (FSI) approach. While CFD neglects the arterial deformation along the cardiac cycle by…

We consider an optimal flow control problem in a patient-specific coronary artery bypass graft with the aim of matching the blood flow velocity with given measurements as the Reynolds number varies in a physiological range. Blood flow is…

The recent discovery of polymer diffusive instability (PDI) by Beneitez et al. (Phys. Rev. Fluids, 2023, 8: L101901) poses challenges in implementing artificial conformation diffusion (ACD) in transition simulations of viscoelastic…

Fluid Dynamics · Physics 2025-10-01 Ming Dong , Dongdong Wan

We study an optimal boundary control problem for the two-dimensional stationary micropolar fluids system with variable density. We control the system by considering boundary controls, for the velocity vector and angular velocity of rotation…

Optimization and Control · Mathematics 2017-06-13 Exequiel Mallea-Zepeda , Elva Ortega-Torres , Élder J. Villamizar-Roa

Fluid resuscitation, also called fluid therapy, is commonly used in treatment of critical care patients. Of the variables inherent to fluid therapy treatment, fluid infusion types are well-studied, but volumetric optimization is not.…

Systems and Control · Electrical Eng. & Systems 2023-12-12 Jacob Grant , Hossein Mirinejad

Background and Objective: Hemodynamic analysis of blood flow through arteries and veins is critical for diagnosing cardiovascular diseases, such as aneurysms and stenoses, and for investigating cardiovascular parameters, such as turbulence…

In this paper, we study initial-boundary value problems for the Cahn--Hilliard system with convection and nonconvex potential, where dynamic boundary conditions are assumed for both the associated order parameter and the corresponding…

Optimization and Control · Mathematics 2018-03-15 Gianni Gilardi , Jürgen Sprekels

Computational fluid dynamics (CFD) based simulation of coronary blood flow provides valuable hemodynamic markers, such as pressure gradients, for diagnosing coronary artery disease (CAD). However, CFD is computationally expensive,…

Computer Vision and Pattern Recognition · Computer Science 2025-12-12 Rene Lisasi , Michele Esposito , Chen Zhao

The problem of quantum state preparation is one of the main challenges in achieving the quantum advantage. Furthermore, classically, for multi-level problems, our ability to solve the corresponding quantum optimal control problems is rather…

Three-dimensional cardiovascular fluid dynamics simulations typically require computation of several cardiac cycles before they reach a periodic solution, rendering them computationally expensive. Furthermore, there is currently no…

Computational Engineering, Finance, and Science · Computer Science 2021-06-28 Martin R. Pfaller , Jonathan Pham , Nathan M. Wilson , David W. Parker , Alison L. Marsden

Several cardiovascular diseases are caused from localised abnormal blood flow such as in the case of stenosis or aneurysms. Prevailing theories propose that the development is caused by abnormal wall-shear stress in focused areas.…

Optimization and Control · Mathematics 2016-07-12 S. W. Funke , M. Nordaas , Øyvind Evju , M. S. Alnæs , K. -A. Mardal

Boundary shape, particularly roughness, strongly controls the amount of wall slip in dense granular flows. In this paper, we aim to quantify and understand which aspects of a dense granular flow are controlled by the boundary condition, and…

Soft Condensed Matter · Physics 2022-05-25 Farnaz Fazelpour , Karen E. Daniels

This paper is concerned with a boundary control problem for the Cahn--Hilliard equation coupled with dynamic boundary conditions. In order to handle the control problem, we restrict our analysis to the case of regular potentials defined on…

Analysis of PDEs · Mathematics 2021-01-20 Pierluigi Colli , Andrea Signori

Computational fluid dynamics (CFD) studies have been increasingly used for blood flow simulations in intracranial aneurysms (ICAs). However, despite the continuous progress of body-fitted CFD solvers, generating a high quality mesh is still…

Computational Engineering, Finance, and Science · Computer Science 2020-07-28 D. S. Lampropoulos , G. C. Bourantas , B. F. Zwick , G. C. Kagadis , A. Wittek , K. Miller , V. C. Loukopoulos

Complicated boundary conditions are essential to accurately describe phenomena arising in nature and engineering. Recently, the investigation of a potential speedup through quantum algorithms in simulating the governing ordinary and partial…

Quantum Physics · Physics 2025-06-30 Philipp Schleich , Tyler Kharazi , Xiangyu Li , Jin-Peng Liu , Alán Aspuru-Guzik , Nathan Wiebe

This work develops scientific computing techniques to further the exploration of using boundary control alone to optimize mixing in Stokes flows. The theoretical foundation including mathematical model and the optimality conditions for…

Optimization and Control · Mathematics 2024-02-22 Weiwei Hu , Xiaoming Zheng

Hemodynamics in the aorta from computational fluid dynamics (CFD) simulations can provide a comprehensive analysis of relevant cardiovascular diseases. Coupling the three-element Windkessel model with the patient-specific CFD simulation to…

Fluid Dynamics · Physics 2022-07-14 Zongze Li , Wenbin Mao

Bounds on turbulent averages in shear flows can be derived from the Navier--Stokes equations by a mathematical approach called the background method. Bounds that are optimal within this method can be computed at each Reynolds number Re by…

Fluid Dynamics · Physics 2026-01-14 Farid Rajkotia-Zaheer , David Goluskin