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Credible intervals and credible sets, such as highest posterior density (HPD) intervals, form an integral statistical tool in Bayesian phylogenetics, both for phylogenetic analyses and for development. Readily available for continuous…

Data Structures and Algorithms · Computer Science 2026-05-05 Jonathan Klawitter , Alexei J. Drummond

There has been an increasing interest in utilizing machine learning methods in inverse problems and imaging. Most of the work has, however, concentrated on image reconstruction problems, and the number of studies regarding the full solution…

Computational Physics · Physics 2024-10-10 Teemu Sahlström , Tanja Tarvainen

Gene trees are evolutionary trees representing the ancestry of genes sampled from multiple populations. Species trees represent populations of individuals -- each with many genes -- splitting into new populations or species. The coalescent…

Populations and Evolution · Quantitative Biology 2010-07-30 Elizabeth S. Allman , James H. Degnan , John A. Rhodes

Motivation: The construction of statistics for summarizing posterior samples returned by a Bayesian phylogenetic study has so far been hindered by the poor geometric insights available into the space of phylogenetic trees, and ad hoc…

Applications · Statistics 2014-10-13 Philipp Benner , Miroslav Bacak , Pierre-Yves Bourguignon

Phylogenetics is a branch of computational biology that studies the evolutionary relationships among biological entities. Its long history and numerous applications notwithstanding, inference of phylogenetic trees from sequence data remains…

Populations and Evolution · Quantitative Biology 2024-03-26 Mingyang Zhou , Zichao Yan , Elliot Layne , Nikolay Malkin , Dinghuai Zhang , Moksh Jain , Mathieu Blanchette , Yoshua Bengio

In many domains, we are interested in analyzing the structure of the underlying distribution, e.g., whether one variable is a direct parent of the other. Bayesian model-selection attempts to find the MAP model and use its structure to…

Machine Learning · Computer Science 2013-01-18 Nir Friedman , Daphne Koller

Decision trees remain one of the most popular machine learning models today, largely due to their out-of-the-box performance and interpretability. In this work, we present a Bayesian approach to decision tree induction via maximum a…

Machine Learning · Computer Science 2023-12-21 Colin Sullivan , Mo Tiwari , Sebastian Thrun

This paper proposes new linear regression models to deal with overdispersed binomial datasets. These new models, called tilted beta binomial regression models, are defined from the tilted beta binomial distribution, proposed assuming that…

Methodology · Statistics 2019-11-26 María Victoria Cifuentes-Amado , Edilberto Cepeda-Cuervo

Dynamic trees are mixtures of tree structured belief networks. They solve some of the problems of fixed tree networks at the cost of making exact inference intractable. For this reason approximate methods such as sampling or mean field…

Machine Learning · Computer Science 2013-01-18 Amos J. Storkey

A metric phylogenetic tree relating a collection of taxa induces weighted rooted triples and weighted quartets for all subsets of three and four taxa, respectively. New intertaxon distances are defined that can be calculated from these…

Populations and Evolution · Quantitative Biology 2020-02-12 Samaneh Yourdkhani , John A. Rhodes

Decision trees are widely used due to their interpretability and efficiency, but they struggle in regression tasks that require reliable extrapolation and well-calibrated uncertainty. Piecewise-constant leaf predictions are bounded by the…

Machine Learning · Computer Science 2026-02-02 Viktor Andonovikj , Sašo Džeroski , Pavle Boškoski

Distribution regression has recently attracted much interest as a generic solution to the problem of supervised learning where labels are available at the group level, rather than at the individual level. Current approaches, however, do not…

Machine Learning · Statistics 2021-01-18 Ho Chung Leon Law , Danica J. Sutherland , Dino Sejdinovic , Seth Flaxman

Many modern experiments, such as microarray gene expression and genome-wide association studies, present the problem of estimating a large number of parallel effects. Bayesian inference is a popular approach for analyzing such data by…

Methodology · Statistics 2018-10-26 J G Liao , Arthur Berg , Timothy L McMurry

We propose a robust and scalable framework for variational Bayes (VB) that effectively handles outliers and contamination of arbitrary nature in large datasets. Our approach divides the dataset into disjoint subsets, computes the posterior…

Machine Learning · Statistics 2025-04-18 Carlos Misael Madrid Padilla , Shitao Fan , Lizhen Lin

Bayesian interpretations of neural processing require that biological mechanisms represent and operate upon probability distributions in accordance with Bayes' theorem. Many have speculated that synaptic failure constitutes a mechanism of…

Neurons and Cognition · Quantitative Biology 2022-10-05 Kevin McKee , Ian Crandell , Rishidev Chaudhuri , Randall O'Reilly

We introduce a notion of finite sampling consistency for phylogenetic trees and show that the set of finitely sampling consistent and exchangeable distributions on n leaf phylogenetic trees is a polytope. We use this polytope to show that…

Combinatorics · Mathematics 2019-03-06 Ben Hollering , Seth Sullivant

Bayesian inference offers benefits over maximum likelihood, but it also comes with computational costs. Computing the posterior is typically intractable, as is marginalizing that posterior to form the posterior predictive distribution. In…

Machine Learning · Computer Science 2023-07-18 Alexander A. Alemi , Ben Poole

In recent years, the literature in the area of Bayesian asymptotics has been rapidly growing. It is increasingly important to understand the concept of posterior consistency and validate specific Bayesian methods, in terms of consistency of…

Statistics Theory · Mathematics 2008-12-18 Taeryon Choi , R. V. Ramamoorthi

Phylogenetic comparative methods correct for shared evolutionary history among a set of non-independent organisms by modeling sample traits as arising from a diffusion process along on the branches of a possibly unknown history. To…

Applications · Statistics 2020-09-30 Paul Bastide , Lam Si Tung Ho , Guy Baele , Philippe Lemey , Marc A Suchard

We present TreeClone, a latent feature allocation model to reconstruct tumor subclones subject to phylogenetic evolution that mimics tumor evolution. Similar to most current methods, we consider data from next-generation sequencing of tumor…

Applications · Statistics 2017-10-26 Tianjian Zhou , Subhajit Sengupta , Peter Mueller , Yuan Ji