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The interpretation of vaccine efficacy estimands is subtle, even in randomized trials designed to quantify immunological effects of vaccination. In this article, we introduce terminology to distinguish between different vaccine efficacy…

Applications · Statistics 2023-11-15 Mats Stensrud , Daniel Nevo , Uri Obolski

Reinforcement learning agents are often updated with human feedback, yet such updates can be unreliable: reward misspecification, preference conflicts, or limited data may leave policies unchanged or even worse. Because policies are…

Human-Computer Interaction · Computer Science 2025-10-14 Matan Solomon , Ofra Amir , Omer Ben-Porat

Variable selection for optimal treatment regime in a clinical trial or an observational study is getting more attention. Most existing variable selection techniques focused on selecting variables that are important for prediction, therefore…

Methodology · Statistics 2014-05-22 Ailin Fan , Wenbin Lu , Rui Song

Herd immunity is shaped not only by the infection capacity of a spreading epidemic or the contact structure of the hosting population, but also by how and under what circumstances individuals acquire immunity. Immunization strategies may…

Physics and Society · Physics 2026-02-20 Sámuel G. Balogh , Gergely Ódor , Márton Karsai

Exploration is a key problem in reinforcement learning, since agents can only learn from data they acquire in the environment. With that in mind, maintaining a population of agents is an attractive method, as it allows data be collected…

Machine Learning · Computer Science 2020-10-08 Jack Parker-Holder , Aldo Pacchiano , Krzysztof Choromanski , Stephen Roberts

Background: Highly effective direct-acting antiviral (DAA) regimens (90% efficacy) are becoming available for hepatitis C virus (HCV) treatment. This therapeutic revolution leads us to consider possibility of eradicating the virus. However,…

Populations and Evolution · Quantitative Biology 2015-06-10 Anthony Cousien , Viet Chi Tran , Sylvie Deuffic-Burban , Marie Jauffret-Roustide , Jean-Stéphane Dhersin , Yazdan Yazdanpanah

Viral campaigns are crucial methods for word-of-mouth marketing in social communities. The goal of these campaigns is to encourage people for activity. The problem of incentivised and non-incentivised campaigns is studied in the paper.…

Social and Information Networks · Computer Science 2013-03-12 Radosław Michalski , Jarosław Jankowski , Przemysław Kazienko

Cluster-randomized trials are often conducted to assess vaccine effects. Defining estimands of interest before conducting a trial is integral to the alignment between a study's objectives and the data to be collected and analyzed. This…

Methodology · Statistics 2019-10-10 Kayla W. Kilpatrick , Michael G. Hudgens , M. Elizabeth Halloran

Randomized experimentation (also known as A/B testing or bucket testing) is widely used in the internet industry to measure the metric impact obtained by different treatment variants. A/B tests identify the treatment variant showing the…

We study a long-run mean-variance team stochastic game (MV-TSG), where each agent shares a common mean-variance objective for the system and takes actions independently to maximize it. MV-TSG has two main challenges. First, the variance…

Multiagent Systems · Computer Science 2025-11-27 Junkai Hu , Li Xia

Estimating individual treatment effects from data of randomized experiments is a critical task in causal inference. The Stable Unit Treatment Value Assumption (SUTVA) is usually made in causal inference. However, interference can introduce…

Methodology · Statistics 2021-05-05 Yunpu Ma , Volker Tresp

Data augmentation is known to contribute significantly to the robustness of machine learning models. In most instances, data augmentation is utilized during the training phase. Test-Time Augmentation (TTA) is a technique that instead…

Machine Learning · Statistics 2024-09-20 Masanari Kimura , Howard Bondell

We review vaccine efficacy (VE) estimands for susceptibility in individual randomized trials with natural (unmeasured) exposure, where individual responses are measured as time from vaccination until an event (e.g., disease from the…

Methodology · Statistics 2026-01-27 Michael P. Fay , Dean Follmann , Bruce J. Swihart , Lauren E. Dang

India locked down 1.3 billion people on March 25, 2020 in the wake of COVID-19 pandemic. The economic cost of it was estimated at USD 98 billion, while the social costs are still unknown. This study investigated how government formed…

Computers and Society · Computer Science 2024-05-10 Ramit Debnath , Ronita Bardhan

Self-adaptive systems frequently use tactics to perform adaptations. Tactic examples include the implementation of additional security measures when an intrusion is detected, or activating a cooling mechanism when temperature thresholds are…

Machine Learning · Computer Science 2022-04-22 Aizaz Ul Haq , Niranjana Deshpande , AbdElRahman ElSaid , Travis Desell , Daniel E. Krutz

As multimodal agents are increasingly trained to operate graphical user interfaces (GUIs) to complete user tasks, they face a growing threat from indirect prompt injection, attacks in which misleading instructions are embedded into the…

Artificial Intelligence · Computer Science 2025-05-21 Yijie Lu , Tianjie Ju , Manman Zhao , Xinbei Ma , Yuan Guo , ZhuoSheng Zhang

Influence maximization problem attempts to find a small subset of nodes that makes the expected influence spread maximized, which has been researched intensively before. They all assumed that each user in the seed set we select is activated…

Social and Information Networks · Computer Science 2021-05-21 Jianxiong Guo , Weili Wu

Influence maximization has been studied for social network analysis, such as viral marketing (advertising), rumor prevention, and opinion leader identification. However, most studies neglect the interplay between influence spread, cost…

Social and Information Networks · Computer Science 2025-09-10 Mingyang Feng , Qi Zhao , Shan He , Yuhui Shi

In social networks, individuals' decisions are strongly influenced by recommendations from their friends and acquaintances. The influence maximization (IM) problem asks to select a seed set of users that maximizes the influence spread,…

Social and Information Networks · Computer Science 2020-08-21 Alessio Arleo , Walter Didimo , Giuseppe Liotta , Silvia Miksch , Fabrizio Montecchiani

An individualized treatment rule (ITR) is a decision rule that aims to improve individual patients health outcomes by recommending optimal treatments according to patients specific information. In observational studies, collected data may…

Methodology · Statistics 2023-10-03 Zeyu Bian , Erica EM Moodie , Susan M Shortreed , Sylvie D Lambert , Sahir Bhatnagar