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Early detection of dementia is critical for timely medical intervention and improved patient outcomes. Neuropsychological tests are widely used for cognitive assessment but have traditionally relied on manual scoring. Automatic dementia…

Machine Learning · Computer Science 2025-07-15 Liming Wang , Saurabhchand Bhati , Cody Karjadi , Rhoda Au , James Glass

Alzheimer's disease (AD), defined as an abnormal buildup of amyloid plaques and tau tangles in the brain can be diagnosed with high accuracy based on protein biomarkers via PET or CSF analysis. However, due to the invasive nature of…

Machine Learning · Computer Science 2026-01-27 Megan A. Witherow , Michael L. Evans , Ahmed Temtam , Hamid R. Okhravi , Khan M. Iftekharuddin

Alzheimer's Disease (AD) is an irreversible neurodegenerative disease characterized by progressive cognitive decline as its main symptom. In the research field of deep learning-assisted diagnosis of AD, traditional convolutional neural…

Image and Video Processing · Electrical Eng. & Systems 2025-07-15 Yang Ming , Jiang Shi Zhong , Zhou Su Juan

Speech, language, and communication deficits are present in most neurodegenerative syndromes. They enable the early detection, diagnosis, treatment planning, and monitoring of neurocognitive disease progression as part of traditional…

Computation and Language · Computer Science 2023-12-07 Charalambos Themistocleous , Kyrana Tsapkini , Dimitrios Kokkinakis

\textbf{Objectives}: We aimed to investigate how errors from automatic speech recognition (ASR) systems affect dementia classification accuracy, specifically in the ``Cookie Theft'' picture description task. We aimed to assess whether…

Computation and Language · Computer Science 2024-01-12 Changye Li , Weizhe Xu , Trevor Cohen , Serguei Pakhomov

Alzheimer's disease (AD) is one of the most common public health issues the world is facing today. This disease has a high prevalence primarily in the elderly accompanying memory loss and cognitive decline. AD detection is a challenging…

Image and Video Processing · Electrical Eng. & Systems 2022-04-04 Zahraa Sh. Aaraji , Hawraa H. Abbas

Large language models (LLMs) have shown great potential for healthcare applications. However, existing evaluation benchmarks provide minimal coverage of Alzheimer's Disease and Related Dementias (ADRD). To address this gap, we introduce…

Computation and Language · Computer Science 2026-05-27 Guangxin Zhao , Jiahao Zheng , Malaz Boustani , Jarek Nabrzyski , Yiyu Shi , Meng Jiang , Zhi Zheng

Alzheimer's Disease destroys brain cells causing people to lose their memory, mental functions and ability to continue daily activities. It is a severe neurological brain disorder which is not curable, but earlier detection of Alzheimer's…

Computer Vision and Pattern Recognition · Computer Science 2017-12-21 Jyoti Islam , Yanqing Zhang

We present an approach to automatic detection of Alzheimer's type dementia based on characteristics of spontaneous spoken language dialogue consisting of interviews recorded in natural settings. The proposed method employs additive logistic…

Audio and Speech Processing · Electrical Eng. & Systems 2018-11-27 Saturnino Luz , Sofia de la Fuente , Pierre Albert

Alzheimer's disease (AD) is a neurodegenerative disorder that affects more than seven million people in the United States alone. AD currently has no cure, but there are ways to potentially slow its progression if caught early enough. In…

Computer Vision and Pattern Recognition · Computer Science 2026-04-09 Mahdi Moghaddami , Mohammad-Reza Siadat , Austin Toma , Connor Laming , Huirong Fu

Early detection is a crucial goal in the study of Alzheimer's Disease (AD). In this work, we describe several techniques to boost the performance of 3D deep convolutional neural networks (CNNs) trained to detect AD using structural brain…

Image and Video Processing · Electrical Eng. & Systems 2020-04-07 Sheng Liu , Chhavi Yadav , Carlos Fernandez-Granda , Narges Razavian

Alzheimers Disease (AD) is a progressive neurodegenerative disorder that poses significant challenges in its early diagnosis, often leading to delayed treatment and poorer outcomes for patients. Traditional diagnostic methods, typically…

Machine Learning · Computer Science 2025-08-06 Tatwadarshi P Nagarhalli , Sanket Patil , Vishal Pande , Uday Aswalekar , Prafulla Patil

The application of machine learning algorithms to the diagnosis and analysis of Alzheimer's disease (AD) from multimodal neuroimaging data is a current research hotspot. It remains a formidable challenge to learn brain region information…

Image and Video Processing · Electrical Eng. & Systems 2022-08-11 Yongcheng Zong , Changhong Jing , Qiankun Zuo

Early diagnosis of Alzheimer's disease (AD) is crucial in facilitating preventive care to delay further progression. This paper presents the development of a state-of-the-art Conformer based speech recognition system built on the…

Audio and Speech Processing · Electrical Eng. & Systems 2022-06-28 Tianzi Wang , Jiajun Deng , Mengzhe Geng , Zi Ye , Shoukang Hu , Yi Wang , Mingyu Cui , Zengrui Jin , Xunying Liu , Helen Meng

In this thesis the aim is to work on optimizing the modern machine learning models for personalized forecasting of Alzheimer Disease (AD) Progression from clinical trial data. The data comes from the TADPOLE challenge, which is one of the…

Machine Learning · Computer Science 2020-08-07 Aritra Banerjee

Disease modifying therapies for Alzheimer's disease demand precise timing decisions, yet current predictive models require longitudinal observations and provide no uncertainty quantification, rendering them impractical at the critical first…

Machine Learning · Computer Science 2026-04-13 Alireza Moayedikia , Sara Fin , Uffe Kock Wiil

Alzheimer's disease (AD) is a progressive and incurable neurodegenerative disease which destroys brain cells and causes loss to patient's memory. An early detection can prevent the patient from further damage of the brain cells and hence…

Image and Video Processing · Electrical Eng. & Systems 2021-01-11 Ali Nawaz , Syed Muhammad Anwar , Rehan Liaqat , Javid Iqbal , Ulas Bagci , Muhammad Majid

Alzheimer Disease poses a significant challenge, necessitating early detection for effective intervention. MRI is a key neuroimaging tool due to its ease of use and cost effectiveness. This study analyzes machine learning methods for MRI…

Neurons and Cognition · Quantitative Biology 2024-08-12 Alwani Liyana Ahmad , Jose Sanchez-Bornot , Roberto C. Sotero , Damien Coyle , Zamzuri Idris , Ibrahima Faye

Speaker embeddings extracted from voice recordings have been proven valuable for dementia detection. However, by their nature, these embeddings contain identifiable information which raises privacy concerns. In this work, we aim to…

Sound · Computer Science 2024-07-08 Dominika Woszczyk , Ranya Aloufi , Soteris Demetriou

Dementia and especially Alzheimer's disease (AD) are the most common causes of cognitive decline in elderly people. A spread of the above mentioned mental health problems in aging societies is causing a significant medical and economic…

Neurons and Cognition · Quantitative Biology 2018-12-03 Tomasz M. Rutkowski , Qibin Zhao , Masao S. Abe , Mihoko Otake