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Electrochemical biosensors and the related concept of redox detection at nanogap electrodes are increasingly explored for ultra-sensitive detection of biomolecules. While experimental demonstrations have been encouraging, the associated…
We review models and approaches for error-control in order to prevent the buildup of noise when gates for digital chemical and biomolecular computing based on (bio)chemical reaction processes are utilized to realize stable, scalable…
Characterizing the anchoring properties of smectic liquid crystals (LCs) in contact with bacterial solutions is crucial for developing biosensing platforms. In this study, we investigate the anchoring properties of a smectic LC when exposed…
Droplet-based microfluidic systems are a promising platform forlab-on-a-chip (LoC) applications. These systems can also be used toenhance LoC applications with integrated droplet control information or for data transmission scenarios in the…
Chemical reactions-based microfluidic circuits are expected to provide new opportunities to perform signal processing functions over molecular domain. To realize this vision, in this article, we exploit and present the digital signal…
A novel approach for electrochemical tuning of alcohol oxidase (AOx) and alcohol dehydrogenase (ADH) biocatalysis towards butanol-1 oxidation by incorporating enzymes in various designs of amperometric biosensors is presented. The…
The properties and fundamental limits of chemical computers have recently attracted significant interest as a model of computation, an unifying principle of cellular organisation and in the context of bio-engineering. As of yet, research in…
We present teraflop-scale calculations of biomolecular electrostatics enabled by the combination of algorithmic and hardware acceleration. The algorithmic acceleration is achieved with the fast multipole method (FMM) in conjunction with a…
Rapid antibiotic susceptibility tests (ASTs) are essential for quick selection of effective drugs to treat bacterial infections at an early stage. However, the most widely used phenotypic ASTs in clinical practice often require 24 - 48…
The lack of rapid antibiotic susceptibility tests adversely affects the treatment of bacterial infections and contributes to increased prevalence of multidrug resistant bacteria. Here, we describe an all-electrical approach that allows for…
Quantum biosensors offer a promising route to overcome the sensitivity and specificity limitations of conventional biosensing technologies. Their ability to detect biochemical signals at extremely low concentrations makes them strong…
An accurate modelling of bio-electrochemical processes that govern Microbial Fuel Cells (MFCs) and mapping their behaviour according to several parameters will enhance the development of MFC technology and enable their successful…
Label-free detecting multiple analytes in a high-throughput fashion has been one of the long-sought goals in biosensing applications. Yet, for all-optical approaches, interfacing state-of-the-art label-free techniques with microfluidics…
This paper reports on the development of a novel CMOS device employing lead-sensing bacteria to assay lead in drinking water. The objective of the PlomBOX project is to develop a low-cost sensor ({\pounds}10) which can expedite access to…
We report a theoretical study of clusters of evanescently-coupled 2D whispering-gallery (WG) mode optical micro-cavities (termed "photonic molecules") as chemosensing and biosensing platforms. Photonic molecules (PMs) supporting modes with…
Digital microfluidic (DMF) biochips are now being extensively used to automate several biochemical laboratory protocols such as clinical analysis, point-of-care diagnostics, and polymerase chain reaction (PCR). In many biological assays,…
In current molecular communication (MC) systems, performing computational operations at the nanoscale remains challenging, restricting their applicability in complex scenarios such as adaptive biochemical control and advanced nanoscale…
Spatial separation of suspended particles based on contrast in their physical or chemical properties forms the basis of various biological assays performed on lab-on-achip devices. To electronically acquire this information, we have…
Precise manipulation of fluids and objects on the micro scale is seldom a simple task, but nevertheless crucial for many applications in life sciences and chemical engineering. We present a microfluidic chip fabricated in silicon-glass,…
The high energy consumption of electronic data processors, together with physical challenges limiting their further improvement, has triggered intensive interest in alternative computation paradigms. Here we focus on network-based…