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Label-free nonlinear optical microscopy has become a powerful tool for biomedical research. However, the possible photodamage risk hinder further clinical applications. To reduce these adverse effects, we constructed a new platform of…

Optics · Physics 2022-10-26 Geng Wang , Stephen A. Boppart , Haohua Tu

Infrared (IR) imaging is one of the significant tools for the quality control measurements of fabricated samples. Standard IR imaging techniques use direct measurements, where light sources and detectors operate at IR range. Due to the…

Quantum Physics · Physics 2020-09-01 Anna V. Paterova , Hongzhi Yang , Zi S. D. Toa , Leonid A. Krivitsky

The LOw Frequency ARray (LOFAR) is capable of imaging spectroscopy of the Sun in the 10-240 MHz frequency range, with high spectral, temporal, and spatial resolution. However, the complex and rapidly varying nature of solar radio emission -…

Solar and Stellar Astrophysics · Physics 2025-08-15 Soham Dey , Divya Oberoi , Pietro Zucca , Mattia Mancini , Deepan Patra , Devojyoti Kansabanik

We perform quantitative phase imaging using phase retrieval to implement synthetic aperture imaging. Compared to digital holography, the developed technique is simpler, less expensive, and more stable.

Optics · Physics 2016-09-07 Dennis J. Lee , Andrew M. Weiner

Synthesizing high-quality images from low-field MRI holds significant potential. Low-field MRI is cheaper, more accessible, and safer, but suffers from low resolution and poor signal-to-noise ratio. This synthesis process can reduce…

Computer Vision and Pattern Recognition · Computer Science 2025-10-16 Zhenxuan Zhang , Peiyuan Jing , Zi Wang , Ula Briski , Coraline Beitone , Yue Yang , Yinzhe Wu , Fanwen Wang , Liutao Yang , Jiahao Huang , Zhifan Gao , Zhaolin Chen , Kh Tohidul Islam , Guang Yang , Peter J. Lally

Organoids, sophisticated in vitro models of human tissues, are crucial for medical research due to their ability to simulate organ functions and assess drug responses accurately. Accurate organoid instance segmentation is critical for…

Computer Vision and Pattern Recognition · Computer Science 2026-01-13 Gui Huang , Kangyuan Zheng , Xuan Cai , Jiaqi Wang , Jianjia Zhang , Kaida Ning , Wenbo Wei , Yujuan Zhu , Jiong Zhang , Mengting Liu

Miniaturized spectrometers employing chip solutions are essential for a wide range of applications, such as wearable health monitoring, biochemical sensing, and portable optical coherence tomography. However, the development of integrated…

Optics · Physics 2025-05-22 Wenzhang Tian , Hao Chen , Mingyuan Zhang , Zengqi Chen , Yeyu Tong

Hyperspectral microscopy is an imaging technique that provides spectroscopic information with high spatial resolution. When applied in the relevant wavelength region, such as in the infrared (IR), it can reveal a rich spectral fingerprint…

We demonstrate a new computational illumination technique that achieves large space-bandwidth-time product, for quantitative phase imaging of unstained live samples in vitro. Microscope lenses can have either large field of view (FOV) or…

Optics · Physics 2015-10-16 Lei Tian , Ziji Liu , Li-Hao Yeh , Michael Chen , Jingshan Zhong , Laura Waller

High-resolution magnetic resonance imaging (MRI) is essential in clinical diagnosis. However, its long acquisition time remains a critical issue. Parallel imaging (PI) is a common approach to reduce acquisition time by periodically skipping…

Image and Video Processing · Electrical Eng. & Systems 2025-06-10 Hao Li , Yusheng Zhou , Jianan Liu , Xiling Liu , Tao Huang , Zhihan Lyu , Weidong Cai , Wei Chen

A miniaturized full-frequency encoded illumination (mini-FEI) chip is presented for high-throughput super-resolution imaging using the spatial frequency shift (SFS) effect. A tunable full SFS scheme is achieved through propagating and…

High-speed image acquisition in light microscopy is essential for a wide range of applications, including observing dynamic biological processes and enabling high-throughput sample analysis. However, traditional imaging speeds are often…

Multispectral imaging (MSI) captures data across multiple spectral bands, offering enhanced informational depth compared to standard RGB imaging and benefiting diverse fields such as agriculture, medical diagnostics, and industrial…

Instrumentation and Detectors · Physics 2025-08-29 Muchen Zhu , Baolei Liu , Yao Wang , Linjun Zhai , Jiaqi Song , Nana Liu , Zhaohua Yang , Lei Ding , Fan Wang

Fluorescence microscopy is a powerful tool for imaging biological samples with molecular specificity. In contrast, phase microscopy provides label-free measurement of the sample's refractive index (RI), which is an intrinsic optical…

Optics · Physics 2022-01-26 Yi Xue , David Ren , Laura Waller

The photo-kinetics of fluorescent molecules have enabled the circumvention of far-field optical diffraction-limit. Despite its enormous potential, the necessity to label the sample may adversely influence the delicate biology under…

Sub-diffraction resolution imaging has played a pivotal role in biological research by visualizing key, but previously unresolvable, sub-cellular structures. Unfortunately, applications of far-field sub-diffraction resolution are currently…

Biological Physics · Physics 2017-05-02 Shwetadwip Chowdhury , Will J. Eldridge , Adam Wax , Joseph A. Izatt

Second harmonic generation (SHG) microscopy is a valuable tool for optical microscopy. SHG microscopy is normally performed as a point scanning imaging method, which lacks phase information and is limited in spatial resolution by the…

Current quantum devices support interactions only between physically adjacent qubits, preventing quantum circuits from being directly executed on these devices. Therefore, SWAP gates are required to remap logical qubits to physical qubits,…

Quantum Physics · Physics 2025-05-15 Kang Xu , Zeyang Li , Xinjian Liu , Dandan Li , Yukun Wang

Label-free optical microscopy through absorption or scattering spectroscopy provides fundamental insights across biology and materials science, yet its sensitivity remains fundamentally limited by photon shot noise. While recent…

Phase imaging is gaining importance due to its applications in fields like biomedical imaging and material characterization. In biomedical applications, it can provide quantitative information missing in label-free microscopy modalities.…

Image and Video Processing · Electrical Eng. & Systems 2026-02-20 Gabriel della Maggiora , Luis Alberto Croquevielle , Harry Horsley , Thomas Heinis , Artur Yakimovich
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